{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T18:41:22Z","timestamp":1760812882044,"version":"build-2065373602"},"reference-count":35,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T00:00:00Z","timestamp":1664323200000},"content-version":"unspecified","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,9,9]]},"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>The aetiology of gastric cancer is still unclear but <jats:italic>Helicobacter pylori<\/jats:italic> (HP) infection and chronic atrophic gastritis (AG) are recognised as two major risk factors for gastric cancer. GastroPanel (GP) test is the first non-invasive diagnostic tool to detect AG and HP infection.<\/jats:p>\n                  <jats:p>The aim of the study is to conduct a systematic review and meta-analysis to review published literature about the GP test for diagnosing AG and HP infection, with the objective of estimating the diagnostic performance indices of GP for AG and HP infection.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>This protocol of systematic review and meta-analysis is reported according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Protocols statement guidelines. PubMed, Embase, Web of Science and Cochrane Library databases will be systematically searched from inception to March 2022 for eligible studies. No language limitations were imposed. The studies will be downloaded into the EndNote V.X9 software and duplicates will be removed. Two review authors independently screened the full text against the inclusion criteria, extracted the data from each included study by using a piloted data extraction form and conducted risk of bias assessment, resolving disagreement by discussion. Results will be synthesised narratively in summary tables, using a random-effect bivariate model, and we fit a hierarchical summary receiver operating characteristic curve.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Ethics and dissemination<\/jats:title>\n                  <jats:p>This systematic review will include data extracted form published studies, therefore, does not require ethics approval. The results of this study will be submitted to a peer-reviewed journal.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PROSPERO registration number<\/jats:title>\n                  <jats:p>CRD42021282616.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-062849","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T11:47:50Z","timestamp":1664365670000},"page":"e062849","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Panel of serum biomarkers (GastroPanel) in diagnosis of atrophic gastritis and <i>Helicobacter pylori<\/i> infection: a protocol of systematic review and meta-analysis"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6494-4380","authenticated-orcid":false,"given":"Dan","family":"Wu","sequence":"first","affiliation":[{"name":"Clinical Laboratory, People's Hospital of Xinjin District Chengdu (Emergency Command Sub-center of Xinjin District, Chengdu), Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anya","family":"Shi","sequence":"additional","affiliation":[{"name":"The Second Clinical Medical Hospital, Lanzhou University, Lanzhou, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haiping","family":"Wang","sequence":"additional","affiliation":[{"name":"Gansu Provincial Key Laboratory of Biotherapy and Regenerative Medicine, The first hospital of Lanzhou university, Lanzhou, Gansu, China"},{"name":"The First Clinical Medical School, Lanzhou University, Lanzhou, Gansu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiuzhong","family":"Yu","sequence":"additional","affiliation":[{"name":"Clinical Laboratory, People's Hospital of Xinjin District Chengdu (Emergency Command Sub-center of Xinjin District, Chengdu), Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,9,28]]},"reference":[{"key":"2025101811162494000_12.9.e062849.1","doi-asserted-by":"crossref","unstructured":"Ferlay J , Colombet M , Soerjomataram I , et al . Cancer statistics for the year 2020: an overview. Int J Cancer 2021.doi:10.1002\/ijc.33588","DOI":"10.1002\/ijc.33588"},{"key":"2025101811162494000_12.9.e062849.2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"2025101811162494000_12.9.e062849.3","doi-asserted-by":"publisher","DOI":"10.7497\/j.issn.2095-3941.2015.0054"},{"key":"2025101811162494000_12.9.e062849.4","doi-asserted-by":"publisher","DOI":"10.1055\/a-0859-1883"},{"key":"2025101811162494000_12.9.e062849.5","doi-asserted-by":"publisher","DOI":"10.1111\/his.12707"},{"key":"2025101811162494000_12.9.e062849.6","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v25.i17.2029"},{"key":"2025101811162494000_12.9.e062849.7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21114012","article-title":"Gastric cancer: epidemiology, risk factors, classification, genomic characteristics and treatment strategies","volume":"21","author":"Machlowska","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2025101811162494000_12.9.e062849.8","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/hel.12339","article-title":"Gastric cancer - clinical and epidemiological aspects","volume":"21 Suppl 1","author":"Venerito","year":"2016","journal-title":"Helicobacter"},{"key":"2025101811162494000_12.9.e062849.9","first-page":"591","article-title":"Risk factors for gastric cancer: a systematic review","volume":"19","author":"Yusefi","year":"2018","journal-title":"Asian Pac J Cancer Prev"},{"key":"2025101811162494000_12.9.e062849.10","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322368"},{"key":"2025101811162494000_12.9.e062849.11","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2018-317556"},{"key":"2025101811162494000_12.9.e062849.12","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.15366"},{"key":"2025101811162494000_12.9.e062849.13","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-312288"},{"key":"2025101811162494000_12.9.e062849.14","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1590\/s0004-2803.201800000-56","article-title":"Comparison between the endoscopic findings and the histological diagnosis of antral GASTRITES","volume":"55","author":"Bertges","year":"2018","journal-title":"Arq Gastroenterol"},{"key":"2025101811162494000_12.9.e062849.15","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.anndiagpath.2011.08.002","article-title":"Correlation between the endoscopic and histologic diagnosis of gastritis","volume":"16","author":"Carr","year":"2012","journal-title":"Ann Diagn Pathol"},{"key":"2025101811162494000_12.9.e062849.16","doi-asserted-by":"crossref","first-page":"216","DOI":"10.3126\/kumj.v13i3.16808","article-title":"Correlation between endoscopic and histopathological findings in gastric lesions","volume":"13","author":"Sharma","year":"2015","journal-title":"Kathmandu Univ Med J"},{"key":"2025101811162494000_12.9.e062849.17","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.dld.2008.02.032","article-title":"Gastric endoscopy in the 21st century: appropriate use of an invasive procedure in the era of non-invasive testing","volume":"40","author":"Graham","year":"2008","journal-title":"Dig Liver Dis"},{"key":"2025101811162494000_12.9.e062849.18","doi-asserted-by":"publisher","DOI":"10.1002\/14651858.CD012080.pub2"},{"key":"2025101811162494000_12.9.e062849.19","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4166\/kjg.2018.72.5.229","article-title":"Diagnosis of Helicobacter pylori Infection","volume":"72","author":"Huh","year":"2018","journal-title":"Korean J Gastroenterol"},{"key":"2025101811162494000_12.9.e062849.20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/978-1-0716-1302-3_2","article-title":"The urea breath test for the noninvasive detection of Helicobacter pylori","volume":"2283","author":"O'Connor","year":"2021","journal-title":"Methods Mol Biol"},{"key":"2025101811162494000_12.9.e062849.21","first-page":"1","article-title":"Cost-effectiveness of the carbon-13 urea breath test for the detection of Helicobacter pylori: an economic analysis","volume":"13","author":"Masucci","year":"2013","journal-title":"Ont Health Technol Assess Ser"},{"key":"2025101811162494000_12.9.e062849.22","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2015-309252"},{"key":"2025101811162494000_12.9.e062849.23","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-200308000-00009"},{"key":"2025101811162494000_12.9.e062849.24","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1097\/MEG.0000000000000257","article-title":"Response to: accuracy of GastroPanel test in detection of atrophic gastritis","volume":"27","author":"McNicholl","year":"2015","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025101811162494000_12.9.e062849.25","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.11083"},{"key":"2025101811162494000_12.9.e062849.26","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.i4086"},{"key":"2025101811162494000_12.9.e062849.27","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.14660"},{"key":"2025101811162494000_12.9.e062849.28","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14248"},{"key":"2025101811162494000_12.9.e062849.29","doi-asserted-by":"crossref","DOI":"10.3892\/etm.2021.10782","article-title":"Value of GastroPanel in the diagnosis of atrophic gastritis","volume":"22","author":"Grad","year":"2021","journal-title":"Exp Ther Med"},{"key":"2025101811162494000_12.9.e062849.30","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13218"},{"key":"2025101811162494000_12.9.e062849.31","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.14833"},{"key":"2025101811162494000_12.9.e062849.32","doi-asserted-by":"publisher","DOI":"10.1111\/hel.12727"},{"key":"2025101811162494000_12.9.e062849.33","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.n71"},{"key":"2025101811162494000_12.9.e062849.34","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1615\/JEnvironPatholToxicolOncol.2018026839","article-title":"Chronic atrophic gastritis: a review","volume":"37","author":"Li","year":"2018","journal-title":"J Environ Pathol Toxicol Oncol"},{"key":"2025101811162494000_12.9.e062849.35","first-page":"3","article-title":"Schistosomes, liver flukes and Helicobacter pylori","volume":"61","year":"1994","journal-title":"IARC Monogr Eval Carcinog Risks Hum"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2022-062849","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T18:16:36Z","timestamp":1760811396000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2022-062849"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9]]},"references-count":35,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2022,9,28]]},"published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1136\/bmjopen-2022-062849"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2022-062849","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"type":"print","value":"2044-6055"},{"type":"electronic","value":"2044-6055"}],"subject":[],"published":{"date-parts":[[2022,9]]}}}