{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T06:55:42Z","timestamp":1787295342544,"version":"build-2736575974"},"reference-count":23,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"unspecified","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000361","name":"Diabetes UK","doi-asserted-by":"crossref","award":["17\/0005627"],"award-info":[{"award-number":["17\/0005627"]}],"id":[{"id":"10.13039\/501100000361","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Chief Scientist Office Scotland","award":["ETM\/47"],"award-info":[{"award-number":["ETM\/47"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,9,16]]},"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Purpose<\/jats:title>\n                    <jats:p>The Scottish Diabetes Research Network (SDRN)-diabetes research platform was established to combine disparate electronic health record data into research-ready linked datasets for diabetes research in Scotland. The resultant cohort, \u2018The SDRN-National Diabetes Dataset (SDRN-NDS)\u2019, has many uses, for example, understanding healthcare burden and socioeconomic trends in disease incidence and prevalence, observational pharmacoepidemiology studies and building prediction tools to support clinical decision making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>We estimate that &gt;99% of those diagnosed with diabetes nationwide are captured into the research platform. Between 2006 and mid-2020, the cohort comprised 472\u2009648 people alive with diabetes at any point in whom there were 4\u2009million person-years of follow-up. Of the cohort, 88.1% had type 2 diabetes, 8.8% type 1 diabetes and 3.1% had other types (eg, secondary diabetes). Data are captured from all key clinical encounters for diabetes-related care, including diabetes clinic, primary care and podiatry and comprise clinical history and measurements with linkage to blood results, microbiology, prescribed and dispensed drug and devices, retinopathy screening, outpatient, day case and inpatient episodes, birth outcomes, cancer registry, renal registry and causes of death.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Findings to date<\/jats:title>\n                    <jats:p>There have been &gt;50 publications using the SDRN-NDS. Examples of recent key findings include analysis of the incidence and relative risks for COVID-19 infection, drug safety of insulin glargine and SGLT2 inhibitors, life expectancy estimates, evaluation of the impact of flash monitors on glycaemic control and diabetic ketoacidosis and time trend analysis showing that diabetic ketoacidosis (DKA) remains a major cause of death under age 50 years. The findings have been used to guide national diabetes strategy and influence national and international guidelines.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Future plans<\/jats:title>\n                    <jats:p>The comprehensive SDRN-NDS will continue to be used in future studies of diabetes epidemiology in the Scottish population. It will continue to be updated at least annually, with new data sources linked as they become available.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-063046","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T11:27:07Z","timestamp":1665574027000},"page":"e063046","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":26,"title":["Cohort profile: the Scottish Diabetes Research Network national diabetes cohort \u2013 a population-based cohort of people with diabetes in Scotland"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3292-4633","authenticated-orcid":false,"given":"Stuart J.","family":"McGurnaghan","sequence":"first","affiliation":[{"name":"MRC Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4234-8040","authenticated-orcid":false,"given":"Luke A. K.","family":"Blackbourn","sequence":"additional","affiliation":[{"name":"MRC Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9009-9179","authenticated-orcid":false,"given":"Thomas M.","family":"Caparrotta","sequence":"additional","affiliation":[{"name":"MRC Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1452-887X","authenticated-orcid":false,"given":"Joseph","family":"Mellor","sequence":"additional","affiliation":[{"name":"MRC Institute of Genetics and Cancer, The University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6345-0194","authenticated-orcid":false,"given":"Anna","family":"Barnett","sequence":"additional","affiliation":[{"name":"Ninewells Hospital, The Scottish Diabetes Research Network, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5220-6244","authenticated-orcid":false,"given":"Andy","family":"Collier","sequence":"additional","affiliation":[{"name":"School of Health and Life Sciences, Glasgow Caledonian University, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1604-2593","authenticated-orcid":false,"given":"Naveed","family":"Sattar","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8214-7625","authenticated-orcid":false,"given":"John","family":"McKnight","sequence":"additional","affiliation":[{"name":"Edinburgh Centre for Endocrinology, Western General Hospital, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4894-9819","authenticated-orcid":false,"given":"John","family":"Petrie","sequence":"additional","affiliation":[{"name":"Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6164-211X","authenticated-orcid":false,"given":"Sam","family":"Philip","sequence":"additional","affiliation":[{"name":"Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9868-5217","authenticated-orcid":false,"given":"Robert","family":"Lindsay","sequence":"additional","affiliation":[{"name":"BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5278-5282","authenticated-orcid":false,"given":"Katherine","family":"Hughes","sequence":"additional","affiliation":[{"name":"Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3550-1764","authenticated-orcid":false,"given":"David","family":"McAllister","sequence":"additional","affiliation":[{"name":"Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0570-5678","authenticated-orcid":false,"given":"Graham P","family":"Leese","sequence":"additional","affiliation":[{"name":"Department of Medicine, Ninewells Hospital and Medical School, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9237-8585","authenticated-orcid":false,"given":"Ewan R","family":"Pearson","sequence":"additional","affiliation":[{"name":"Division of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7824-2569","authenticated-orcid":false,"given":"Sarah","family":"Wild","sequence":"additional","affiliation":[{"name":"Usher Institute, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5217-1034","authenticated-orcid":false,"given":"Paul M","family":"McKeigue","sequence":"additional","affiliation":[{"name":"Usher Institute, College of Medicine and Veterinary Medicine, The University of Edinburgh, Edinburgh, 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