{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T23:22:21Z","timestamp":1785280941240,"version":"3.55.0"},"reference-count":49,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T00:00:00Z","timestamp":1676505600000},"content-version":"unspecified","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,2,5]]},"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Cardiac involvement in patients with systemic sclerosis (SSc) is associated with poor prognosis. Early detection of myocardial impairment is essential for treatment. The present study aimed to systematically review the value of detecting subclinical myocardial impairment in SSc patients using myocardial strain obtained from speckle tracking echocardiography (STE).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A systematic review and meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data sources<\/jats:title>\n                    <jats:p>The PubMed, Embase and Cochrane library databases were searched in the period from the earliest available indexing date to 30 September 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Eligibility criteria for selecting studies<\/jats:title>\n                    <jats:p>Studies evaluating myocardial function in SSc patients comparison with healthy controls based on myocardial strain data obtained from STE were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Data extraction and synthesis<\/jats:title>\n                    <jats:p>Ventricle and atrium data on myocardial strain were extracted to assessing the mean difference (MD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 30 studies were included in the analysis. Left ventricular global longitudinal strain (MD: \u22122.28, 95% CI \u22122.85 to \u20131.71), left ventricular global circumferential strain (MD: \u22123.27, 95%\u2009CI \u22124.26 to \u20132.29) and left ventricular global radial strain (MD: \u22123.95, 95%\u2009CI \u22126.33 to \u20131.57) was significantly lower in SSc patients than in healthy controls. Right ventricular global wall strain (MD: \u22122.68, 95%\u2009CI \u22123.21 to \u20132.16) was also decreased in SSc patients. STE revealed significant differences in several atrial parameters including left atrial reservoir strain (MD: \u22127.75, 95%\u2009CI \u221211.66 to \u20133.85) and left atrial conduit strain (MD: \u22123.26, 95%\u2009CI \u22126.50 to \u20130.03), as well as right atrial reservoir strain (MD: \u22127.37, 95%\u2009CI \u221211.20 to \u20133.53) and right atrial conduit strain (MD: \u22125.44, 95%\u2009CI \u22129.15 to \u20131.73). There were no differences in left atrial contractile strain (MD: \u22121.51, 95%\u2009CI \u22125.34 to 2.33).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>SSc patients have a lower strain than healthy controls for the majority of STE parameters, indicating the presence of an impaired myocardium involving both the ventricle and atrium.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-063364","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T10:25:48Z","timestamp":1676543148000},"page":"e063364","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Cardiac involvement assessment in systemic sclerosis using speckle tracking echocardiography: a systematic review and 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