{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:43:21Z","timestamp":1783550601752,"version":"3.55.0"},"reference-count":13,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T00:00:00Z","timestamp":1683763200000},"content-version":"unspecified","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,4,28]]},"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                  <jats:title>Purpose<\/jats:title>\n                  <jats:p>The Lifelines Reproductive Origins of Adult Health and Disease (Lifelines-ROAHD) cohort provides a uniquely detailed dataset allowing investigations of determinants of reproductive health as well as the influence of reproductive events on future health and disease of mother and child(ren). Lifelines-ROAHD cohort is embedded in the population-based Lifelines cohort study.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>In total, 5412\u2009women of reproductive age (20\u201345 years) were included in the Lifelines-ROAHD cohort, in the period 2017\u20132018.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Findings to date<\/jats:title>\n                  <jats:p>In the population, 45.6% of the women indicated that they had a natural menstrual cycle. In total, 908\u2009women (16.8%) consulted a healthcare provider for infertility; subsequently diagnosed fertility problems were anovulation (24.4%), male partner infertility problems (22.5%) or unexplained infertility (22.2%). Women underwent various consecutive assisted reproductive treatments, for example, ovulation induction (19.8%) or in vitro fertilisation (5.4%). In total, 2808\u2009women experienced 6158 pregnancies and 5068 births. Adverse pregnancy outcomes were miscarriage (14.3%), ectopic pregnancy (0.9%) or termination of pregnancy or medical abortion (2.0 %). The modes of delivery were vaginal births (74.9%), instrumental vaginal births (11.9%), elective caesarean section (3.9%) and emergency caesarean section (9.3%). Birth outcomes were born alive at term (93.6%), born alive (very) pre-term (5.8%), stillbirth (0.316%) and neonatal death (0.197%). Additional data about 2660 most recent pregnancies showed that 19.9% of the women had irregular working hours. One year postpartum, women indicated adverse physical health issues in one or more domains, range 0.5%\u201312.5%. They also indicated adverse psychological health issues in one or more domains, range 0.7%\u20131.6%, and 1.6% experienced diminished sexual health.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Future plans<\/jats:title>\n                  <jats:p>Due to the embedding of Lifelines-ROAHD cohort in the original Lifelines cohort, the women will be longitudinally followed. Additionally, we aim to collect data with a second online questionnaire aiming to complete women\u2019s reproductive histories, by collecting data about potential first and subsequent pregnancies conceived after the date of completion of baseline Lifelines-ROAHD cohort.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-063890","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T10:16:07Z","timestamp":1683800167000},"page":"e063890","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Women of reproductive age living in the North of the Netherlands: Lifelines Reproductive Origins of Adult Health and Disease (Lifelines-ROAHD) cohort"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2342-0799","authenticated-orcid":false,"given":"Lilian L","family":"Peters","sequence":"first","affiliation":[{"name":"Department of Primay and Long-Term Care, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"},{"name":"Department of Midwifery Science\/Midwifery Academy Amsterdam Groningen, Amsterdam University Medical Center, location Vrije Universiteit Amsterdam, Amsterdam, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6629-318X","authenticated-orcid":false,"given":"Henk","family":"Groen","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Sijtsma","sequence":"additional","affiliation":[{"name":"Lifelines Cohort Study, University Medical Centre Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2654-1038","authenticated-orcid":false,"given":"Danielle","family":"Jansen","sequence":"additional","affiliation":[{"name":"Department of Primay and Long-Term Care, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4441-7142","authenticated-orcid":false,"given":"Annemieke","family":"Hoek","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Section Reproductive Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,5,11]]},"reference":[{"key":"2025101810413835000_13.5.e063890.1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)91340-1"},{"key":"2025101810413835000_13.5.e063890.2","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2019-316929"},{"key":"2025101810413835000_13.5.e063890.3","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyu229"},{"key":"2025101810413835000_13.5.e063890.4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0137203","article-title":"Representativeness of the lifelines cohort study","volume":"10","author":"Klijs","year":"2015","journal-title":"PLoS ONE"},{"key":"2025101810413835000_13.5.e063890.5","doi-asserted-by":"publisher","DOI":"10.1007\/s10654-007-9204-4"},{"key":"2025101810413835000_13.5.e063890.6","doi-asserted-by":"crossref","first-page":"e295","DOI":"10.1093\/ije\/dyab257","article-title":"Cohort profile update: lifelines, a three-generation cohort study and Biobank","volume":"51","author":"Sijtsma","year":"2022","journal-title":"Int J Epidemiol"},{"key":"2025101810413835000_13.5.e063890.7","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.11.2451"},{"key":"2025101810413835000_13.5.e063890.8","doi-asserted-by":"publisher","DOI":"10.1159\/000228980"},{"key":"2025101810413835000_13.5.e063890.9","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000381449","article-title":"Determining pre-conception risk profiles using a national online self-reported risk assessment: a cross-sectional study","volume":"18","author":"Vink-van Os","year":"2015","journal-title":"Public Health Genomics"},{"key":"2025101810413835000_13.5.e063890.10","doi-asserted-by":"crossref","DOI":"10.1186\/s12884-020-02869-0","article-title":"Measuring women\u2019s experiences of decision-making and aspects of midwifery support: a confirmatory factor analysis of the revised childbirth experience 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