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Non-nutritive sweeteners and sweetness enhancers (S&amp;SEs) can maintain sweet taste in the absence of energy, but little is known about the impact of acute and repeated consumption of S&amp;SE in foods on appetite. This study aims to evaluate the effect of acute and repeated consumption of two individual S&amp;SEs and two S&amp;SE blends in semisolid and solid foods on appetite and related behavioural, metabolic and health outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and analysis<\/jats:title><jats:p>A work package of the SWEET Project; this study consists of five double-blind randomised cross-over trials which will be carried out at five sites across four European countries, aiming to have n=213. Five food matrices will be tested across three formulations (sucrose-sweetened control vs two reformulated products with S&amp;SE blends and no added sugar). Participants (body mass index 25\u201335\u2009kg\/m<jats:sup>2<\/jats:sup>; aged 18\u201360 years) will consume each formulation for 14 days. The primary endpoint is composite appetite score (hunger, inverse of fullness, desire to eat and prospective food consumption) over a 3-hour postprandial incremental area under the curve during clinical investigation days on days 1 and 14.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ethics and dissemination<\/jats:title><jats:p>The trial has been approved by national ethical committees and will be conducted in accordance with the Declaration of Helsinki. Results will be published in international peer-reviewed open-access scientific journals. Research data from the trial will be deposited in an open-access online research data archive.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration number<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT04633681\">NCT04633681<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2022-063903","type":"journal-article","created":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T16:56:44Z","timestamp":1671814604000},"page":"e063903","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Acute and repeated impact of sweeteners and sweetness enhancers in solid and semi-solid foods on appetite: protocol for a multicentre, cross-over, RCT in people with overweight\/obesity \u2013 the SWEET 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