{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T15:37:40Z","timestamp":1773329860147,"version":"3.50.1"},"reference-count":18,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2022,12,14]],"date-time":"2022-12-14T00:00:00Z","timestamp":1670976000000},"content-version":"unspecified","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,11,15]]},"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Hypertension has been considered a contraindication for living kidney donation in the past. Since transplantation from living kidney donors remains the best modality for kidney failure, there is now an increased acceptance of living kidney donors with hypertension. However, the safety of this practice for the cardiovascular and kidney health of the donor is unclear. We will conduct a systematic review to summarise and synthesise the existing literature on this topic.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>A systematic review of prospective randomised and non-randomised and retrospective studies will be conducted. MEDLINE, EMBASE, Cochrane CENTRAL and EBM reviews published from January 1946 to December 2021 will be reviewed. Primary outcome will be the difference in the survival, major adverse cardiovascular events, estimated glomerular filtration rate of 45\u2009mL\/min or less and development of end-stage kidney failure, between living kidney donors with and without hypertension. Study screening, selection, and data extraction will be performed by two independent reviewers. Studies must fulfil all eligibility criteria for inclusion into the systematic review and meta-analysis. The Risk of Bias in Non-Randomised studies tool will be used to assess bias.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>No ethical approval is required for this systematic review. The results of this review will be disseminated in a peer-reviewed, open-access journal to ensure access to all stakeholders in kidney transplantation and to inform clinical guidelines on the evaluation and follow-up care of living kidney donor candidates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD42022300119.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-064132","type":"journal-article","created":{"date-parts":[[2022,12,15]],"date-time":"2022-12-15T12:05:21Z","timestamp":1671105921000},"page":"e064132","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Kidney function, cardiovascular outcomes and survival of living kidney donors with hypertension: a systematic review protocol"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4106-0451","authenticated-orcid":false,"given":"Ann","family":"Bugeja","sequence":"first","affiliation":[{"name":"Division of Nephrology, Department of Medicine, The Ottawa Hospital, University of Ottawa, Kidney Research Centre, and Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariam","family":"Eldaba","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sumaiya","family":"Ahmed","sequence":"additional","affiliation":[{"name":"Department of Medicine, The Ottawa Hospital and University of Ottawa, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Risa","family":"Shorr","sequence":"additional","affiliation":[{"name":"Learning Services, The Ottawa Hospital, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward G","family":"Clark","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, The Ottawa Hospital, University of Ottawa, Kidney Research Centre, and Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin D","family":"Burns","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, The Ottawa Hospital, University of Ottawa, Kidney Research Centre, and Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg","family":"Knoll","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, The Ottawa Hospital, University of Ottawa, Kidney Research Centre, and Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swapnil","family":"Hiremath","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Department of Medicine, The Ottawa Hospital, University of Ottawa, Kidney Research Centre, and Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,12,15]]},"reference":[{"key":"2025121510060903000_12.12.e064132.1","doi-asserted-by":"crossref","unstructured":"Bailey P , Edwards A , Courtney AE . 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Available: https:\/\/www.cihi.ca\/en\/search?query=kidney+transplant&Search+Submit= [Accessed 12 Apr 2022]."},{"key":"2025121510060903000_12.12.e064132.3","doi-asserted-by":"publisher","DOI":"10.2215\/CJN.11220918"},{"key":"2025121510060903000_12.12.e064132.4","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-145-3-200608010-00006"},{"key":"2025121510060903000_12.12.e064132.5","doi-asserted-by":"publisher","DOI":"10.1097\/01.tp.0000256284.78721.ba"},{"key":"2025121510060903000_12.12.e064132.6","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.285141"},{"key":"2025121510060903000_12.12.e064132.7","doi-asserted-by":"crossref","first-page":"1278","DOI":"10.1097\/TP.0000000000000877","article-title":"Risk-Factor profile of living kidney donors: the Australia and New Zealand dialysis and transplant living kidney donor registry 2004-2012","volume":"100","author":"Clayton","year":"2016","journal-title":"Transplantation"},{"key":"2025121510060903000_12.12.e064132.8","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1111\/ajt.15964","article-title":"Metabolic, cardiovascular, and substance use evaluation of living kidney donor candidates: US practices in 2017","volume":"20","author":"Garg","year":"2020","journal-title":"Am J Transplant"},{"key":"2025121510060903000_12.12.e064132.9","doi-asserted-by":"crossref","first-page":"S7","DOI":"10.1097\/TP.0000000000001769","article-title":"KDIGO clinical practice guideline on the evaluation and care of living kidney donors","volume":"101","author":"Lentine","year":"2017","journal-title":"Transplantation"},{"key":"2025121510060903000_12.12.e064132.10","unstructured":"National Institute for Health Research . 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