{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,22]],"date-time":"2026-01-22T12:39:30Z","timestamp":1769085570931,"version":"3.49.0"},"reference-count":14,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T00:00:00Z","timestamp":1665964800000},"content-version":"unspecified","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Region Zealand Health Science Research Foundation","award":["R32-A1108-B14"],"award-info":[{"award-number":["R32-A1108-B14"]}]},{"name":"Department of Orthopaedics, Zealand University Hospital","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,10,4]]},"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>An increasing number of patients with displaced proximal humerus fractures (PHF) are being offered non-surgical treatment, including short immobilisation and structured rehabilitation. There are no randomised controlled trials (RCTs) comparing structured rehabilitation with non-structured rehabilitation to investigate the benefits of structured rehabilitation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>In this RCT, patients with a displaced PHF will be assessed for eligibility at a Danish university outpatient clinic. Patients with competing injuries or patients offered surgery will be excluded, and randomisation will be 1:1. All patients will receive standard orthopaedic follow-up, including 14-day postinjury immobilisation, and advice about returning to activities of daily living before being allocated to structured rehabilitation in the municipalities or non-structured rehabilitation. The primary outcome is the between-group difference in the Oxford Shoulder Score (0\u201348 points, 48=best, minimal clinically important difference=10) at 6 months. A sample size of 60 patients will allow us to show a 10-point difference with 80% power.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Funded by Department of Orthopaedics, Zealand University Hospital (grant number N\/A) and Region Zealand Health Science Research Foundation (R32-A1108-B14), 14 January 2022; The Ethics committee in Region Zealand approved (EMN-2022-02449), 8 April 2022. The site opened on 5 May 2022, and the final results will be updated on trial registries, submitted to a peer-reviewed journal, and inform rehabilitation strategies after displaced PHFs. Protocol version 1, 21 April 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT05302089\">NCT05302089<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-064156","type":"journal-article","created":{"date-parts":[[2022,10,17]],"date-time":"2022-10-17T11:19:06Z","timestamp":1666005546000},"page":"e064156","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Effect of structured rehabilitation versus non-structured rehabilitation following non-surgical management of displaced proximal humerus fractures: a protocol for a randomised clinical trial"],"prefix":"10.1136","volume":"12","clinical-trial-number":[{"clinical-trial-number":"nct05302089","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct05302089","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3050-0028","authenticated-orcid":false,"given":"Behnam","family":"Liaghat","sequence":"first","affiliation":[{"name":"Centre for Evidence-Based Orthopaedics (CEBO), Department of Orthopaedic Surgery, Zealand University Hospital, K\u00f8ge, Denmark"},{"name":"Department of Sports Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5337-758X","authenticated-orcid":false,"given":"Stig","family":"Brorson","sequence":"additional","affiliation":[{"name":"Centre for Evidence-Based Orthopaedics (CEBO), Department of Orthopaedic Surgery, Zealand University Hospital, K\u00f8ge, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,10,17]]},"reference":[{"key":"2025121407262358000_12.10.e064156.1","doi-asserted-by":"crossref","DOI":"10.1186\/s13018-021-02551-x","article-title":"Epidemiology of proximal humerus fractures","volume":"16","author":"Iglesias-Rodr\u00edguez","year":"2021","journal-title":"J Orthop Surg Res"},{"key":"2025121407262358000_12.10.e064156.2","doi-asserted-by":"publisher","DOI":"10.1080\/000164701753542023"},{"key":"2025121407262358000_12.10.e064156.3","first-page":"CD000434","article-title":"Interventions for treating proximal humeral fractures in adults","volume":"6","author":"Handoll","year":"2022","journal-title":"Cochrane Database Syst Rev"},{"key":"2025121407262358000_12.10.e064156.4","doi-asserted-by":"crossref","unstructured":"Brorson S , Palm H . Proximal Humeral Fractures: The Choice of Treatment. In: Falaschi P , Marsh D , eds. Orthogeriatrics: the management of older patients with fragility fractures. 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