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More than 60% of the patients present relapsing and remitting chronic arthralgia with debilitating pain lasting for years. Transcranial direct current stimulation (tDCS) appears promising as a novel neuromodulation approach for pain-related networks to alleviate pain in several pain syndromes. Our objective is to evaluate the effectiveness of tDCS (C3\/Fp2 montage) on pain, muscle strength, functionality and quality of life in chronic arthralgia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This protocol is a single-centre, parallel-design, double-blind, randomised, sham-controlled trial. Forty participants will be randomised to either an active or sham tDCS. A total of 10 sessions will be administered over 2 weeks (one per weekday) using a monophasic continuous current with an intensity of 2 mA for 20\u2009min. Participants will be evaluated at baseline, after the 10th session, 2 weeks and 4 weeks after intervention. Primary outcome: pain assessed using numeric rating scale and algometry. Secondary outcomes: muscle strength, functionality and quality of life. The effects of stimulation will be calculated using a mixed analysis of variance model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The study was approved by the ethics committee of the Faculty of Health Sciences of Trair\u00ed, Federal University of Rio Grande do Norte (No. 2.413.851) and registered on the Brazilian Registry of Clinical Trials. Study results will be disseminated through presentations at conferences and publications in peer-reviewed journals.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>RBR-469yd6.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-065387","type":"journal-article","created":{"date-parts":[[2022,10,26]],"date-time":"2022-10-26T11:22:20Z","timestamp":1666783340000},"page":"e065387","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Ten sessions of transcranial direct current stimulation for chronic chikungunya arthralgia: study protocol for a randomised clinical trial"],"prefix":"10.1136","volume":"12","author":[{"given":"Abra\u00e3o S\u00e9rvulo do","family":"Nascimento","sequence":"first","affiliation":[{"name":"Graduate Program in Rehabilitation Science, Federal University of Rio Grande do Norte, Santa Cruz, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f4nio Felipe Lopes","family":"Cavalcante","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Science, Federal University of Rio Grande do Norte, Natal, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago Anderson Brito De","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Graduate Program in Neuroengineering, Instituto Santos Dumont, Macaiba, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Danyell Dantas","family":"da Silva","sequence":"additional","affiliation":[{"name":"Graduate Program in Rehabilitation Science, Federal University of Rio Grande do Norte, Santa Cruz, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edson","family":"Silva-Filho","sequence":"additional","affiliation":[{"name":"Graduate Program in Rehabilitation Science, Federal University of Rio Grande do Norte, Santa Cruz, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandre","family":"Okano","sequence":"additional","affiliation":[{"name":"Federal University of ABC Center of Mathematics Computing and Cognition, Santo Andre, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucien","family":"Peroni Gualdi","sequence":"additional","affiliation":[{"name":"Graduate Program in Rehabilitation Science, Federal University of Rio Grande do Norte, Santa Cruz, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7227-1075","authenticated-orcid":false,"given":"Rodrigo","family":"Pegado","sequence":"additional","affiliation":[{"name":"Graduate Program in Health Science, Federal University of Rio Grande do Norte, Natal, Brazil"},{"name":"Graduate Program in Physical Therapy, Federal University of Rio Grande do Norte, Natal, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,10,26]]},"reference":[{"key":"2025121513352522000_12.10.e065387.1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1590\/0001-3765202120200670","article-title":"Dynamics of transmission of urban arbovirus dengue, Zika and Chikungunya in southwestern region of Bahia, Brazil","volume":"93","author":"Souza","year":"2021","journal-title":"An Acad Bras Cienc"},{"key":"2025121513352522000_12.10.e065387.2","unstructured":"WHO, PAHO . 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