{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T18:17:48Z","timestamp":1793038668307,"version":"4.5.0"},"reference-count":51,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T00:00:00Z","timestamp":1669075200000},"content-version":"unspecified","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100011501","name":"Qinghai Provincial Department of Science and Technology","doi-asserted-by":"publisher","award":["2019-ZJ-7051"],"award-info":[{"award-number":["2019-ZJ-7051"]}],"id":[{"id":"10.13039\/501100011501","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:sec><jats:title>Background and objectives<\/jats:title><jats:p>The epidemiology of stroke at high altitudes has not been extensively studied, especially at heights of 4000\u2009m and above. Thus, stroke prevention and treatment at high altitudes are challenging. We conducted a cross-sectional study to estimate the prevalence of stroke, the detection rate of individuals at high risk of stroke and the risk factors for stroke in the Qinghai-Tibet Plateau in China, a high altitude plateau that inhabits approximately 15 million people.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A population-based cross-sectional study in the Qinghai-Tibet Plateau.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Data were collected from participants through face-to-face screening using a primary screening table. The table relied on the China National Stroke Screening and Prevention Project.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>A total of 10\u2009700 residents aged \u226540 years and living on the Qinghai-Tibet Plateau for more than 6\u2009months participated from January 2019 to December 2021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>The primary screening table included basic demographic information, medical history information, personal lifestyle habits and physical examination information.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 10\u2009056 people were included in the analysis. The prevalence of stroke was 2.3% (95% CI 2.0% to 2.6%), and the detection rate of individuals at high risk of stroke was 26.2% (95% CI 25.3% to 27.0%). The prevalence of stroke and the detection rate of individuals at high risk of stroke increased with altitude (p&lt;0.01), and the prevalence of stroke at high altitudes was almost 2.2 times that at mid-altitudes (p&lt;0.01). After full adjustments, age, residence, hypertension, family history of stroke and smoking were significantly associated with stroke (p&lt;0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The prevalence of stroke, the related risk factors and the detection rate of high-risk individuals were clarified. The prevalence rates of hypertension, overweight or obesity and diabetes in the Qinghai-Tibet Plateau were all higher than the Chinese average. Higher-altitude exposure may be an independent risk factor for stroke.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2022-065605","type":"journal-article","created":{"date-parts":[[2022,11,22]],"date-time":"2022-11-22T15:55:12Z","timestamp":1669132512000},"page":"e065605","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence of stroke and associated risk factors: a population-based cross-sectional study from the Qinghai-Tibet Plateau of China"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2355-1759","authenticated-orcid":false,"given":"ZhenHua","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QuanZhong","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"WeiZhong","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"QingLi","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,11,22]]},"reference":[{"key":"2022112207501708000_12.11.e065605.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(21)00252-0"},{"key":"2022112207501708000_12.11.e065605.2","doi-asserted-by":"crossref","first-page":"e1711","DOI":"10.1212\/WNL.0000000000011636","article-title":"Nationwide trends in incidence and mortality of stroke among younger and older adults in Denmark","volume":"96","author":"Skajaa","year":"2021","journal-title":"Neurology"},{"key":"2022112207501708000_12.11.e065605.3","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(18)32203-7"},{"key":"2022112207501708000_12.11.e065605.4","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804492"},{"key":"2022112207501708000_12.11.e065605.5"},{"key":"2022112207501708000_12.11.e065605.6","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)30427-1"},{"key":"2022112207501708000_12.11.e065605.7","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00551-6"},{"key":"2022112207501708000_12.11.e065605.8","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2020-000457"},{"key":"2022112207501708000_12.11.e065605.9","doi-asserted-by":"publisher","DOI":"10.1136\/svn-2019-000242"},{"key":"2022112207501708000_12.11.e065605.10","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2021.20745","article-title":"Clinical characteristics, management, and in-hospital outcomes in patients with stroke or transient ischemic attack in China","volume":"4","author":"Gu","year":"2021","journal-title":"JAMA Netw Open"},{"key":"2022112207501708000_12.11.e065605.11","doi-asserted-by":"crossref","unstructured":"Tremblay JC , Ainslie PN . 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