{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,4]],"date-time":"2025-12-04T14:44:53Z","timestamp":1764859493216,"version":"build-2065373602"},"reference-count":35,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,11,16]]},"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Patients receiving a haematopoietic stem cell transplant (HSCT) are subjected to complex oral medications based on prophylactic and immunosuppressive treatments. Adherence to medication plays a role in survival, and medication non-adherence (MNA) is closely associated with graft-versus-host disease and other complications. The aim of this systematic review is to summarise the available evidence regarding prevalence rates of medication adherence, the risk factors of MNA, the effectiveness of interventions to increase medication adherence and the outcomes associated with MNA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>We designed a systematic review according to the Joanna Briggs Institute methodology. We will search the Cochrane Library and the CINAHL, EMBASE, MEDLINE via PubMed, PsycINFO and Scopus databases. We will include published and unpublished primary studies: (a) on humans, from inception until 10 May 2022; (b) written in any language; (c) experimental (randomised and non-randomised), observational (prospective, retrospective cohort and case\u2013control), correlational, cross-sectional and longitudinal; and (d) with a low risk of bias, according to the quality assessment we perform. We will exclude secondary and qualitative studies, protocols, publications without original data, including paediatrics or related to autologous HSCT. The primary outcome will be the prevalence of oral medication adherence; the secondary outcomes will be the risk factors of MNA, the interventions aimed at increasing medication adherence and the outcomes of MNA. Two researchers will independently screen the eligible studies, then extract and describe the data. Disagreements will be resolved by a third researcher. We will provide a qualitative narrative synthesis of the findings.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Ethics and dissemination<\/jats:title>\n                  <jats:p>Ethical approval is not required given that previously published studies will be used. We will disseminate the findings through conference presentations and publications in international peer-reviewed scientific journals.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PROSPERO registration number<\/jats:title>\n                  <jats:p>CRD42022315298.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-065676","type":"journal-article","created":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T13:58:05Z","timestamp":1669903085000},"page":"e065676","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Medication adherence among allogeneic haematopoietic stem cell transplant recipients: a systematic review protocol"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1174-741X","authenticated-orcid":false,"given":"Chiara","family":"Visintini","sequence":"first","affiliation":[{"name":"Department of Biomedicine and Prevention, University of Tor Vergata, Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Mansutti","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Udine, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3508-844X","authenticated-orcid":false,"given":"Alvisa","family":"Palese","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, University of Udine, Udine, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,12,1]]},"reference":[{"key":"2025101810423628000_12.12.e065676.1","doi-asserted-by":"publisher","DOI":"10.1038\/s41409-021-01227-8"},{"key":"2025101810423628000_12.12.e065676.2","unstructured":"Phelan R , Arora M , Chen M . Current use and outcome of hematopoietic stem cell transplantation: CIBMTR us summary slides, 2020. Available: CIBMTR Summary Slides - HCT Trends and Survival Data [Accessed 03 Jan 2022]."},{"key":"2025101810423628000_12.12.e065676.3","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1007\/s11096-017-0436-4","article-title":"Factors relevant to medication non-adherence in kidney transplant: a systematic review","volume":"39","author":"Belaiche","year":"2017","journal-title":"Int J Clin Pharm"},{"key":"2025101810423628000_12.12.e065676.4","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.bbmt.2020.05.020","article-title":"A prospective survey of outpatient medication adherence in adult allogeneic hematopoietic stem cell transplantation patients","volume":"26","author":"Ice","year":"2020","journal-title":"Biol Blood Marrow Transplant"},{"key":"2025101810423628000_12.12.e065676.5","unstructured":"National Cancer Institute [homepage on the Internet] . 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Who adherence meeting report. Geneva, SW: World Health Organization, 2001."},{"key":"2025101810423628000_12.12.e065676.11","doi-asserted-by":"crossref","first-page":"30","DOI":"10.7326\/M18-0543","article-title":"ESPACOMP medication adherence reporting guideline (emerge)","volume":"169","author":"De Geest","year":"2018","journal-title":"Ann Intern Med"},{"key":"2025101810423628000_12.12.e065676.12","doi-asserted-by":"publisher","DOI":"10.4065\/mcp.2010.0575"},{"key":"2025101810423628000_12.12.e065676.13","unstructured":"Sabat\u00e9 E , Adherence D . Adherence to long-term therapies: evidence for action. 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