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There is a lack of knowledge about illness uncertainty, coping style and demoralisation in patients with breast cancer. The current study explored the relationship between illness uncertainty and demoralisation among those patients, as well as the potential mediating role of coping style.<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>A cross-sectional study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Setting<\/jats:title><jats:p>Participants were recruited from the Breast Tumor Center in a tertiary hospital in Shijiazhuang, Hebei province.<\/jats:p><\/jats:sec><jats:sec><jats:title>Participants<\/jats:title><jats:p>A total of 211 patients with breast cancer completed the survey.<\/jats:p><\/jats:sec><jats:sec><jats:title>Outcome measures<\/jats:title><jats:p>A total of 211 patients with breast cancer completed the Mishel\u2019s Uncertainty in Illness Scale, Trait Coping Style Questionnaire and the Mandarin version of Demoralization Scale (DS-MV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the patients, 47.40% exhibited symptoms of demoralisation (DS-MV&gt;30), and the mean of demoralisation score was (29.55\u00b113.21). The results demonstrated that illness uncertainty and negative coping styles were positively related to demoralisation (p&lt;0.001), while active coping styles were negatively related to demoralisation (p&lt;0.001). Importantly, coping styles could partially mediate the relationship between illness uncertainty and demoralisation (p&lt;0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study illustrated that illness uncertainty was associated with demoralisation in patients with breast cancer, and coping style acted as a mediator in this relationship. 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