{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T10:37:01Z","timestamp":1765881421842,"version":"3.48.0"},"reference-count":13,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T00:00:00Z","timestamp":1672272000000},"content-version":"unspecified","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["[No. 82160129]"],"award-info":[{"award-number":["[No. 82160129]"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Science and technology project of Chengguan District of Lanzhou City","award":["[2019RCCX0034]"],"award-info":[{"award-number":["[2019RCCX0034]"]}]},{"name":"Science and technology project of Chengguan District of Lanzhou City","award":["[2020JSCX0073]"],"award-info":[{"award-number":["[2020JSCX0073]"]}]},{"name":"Science and technology project of Chengguan District of Lanzhou City","award":["[2020SHFZ0039]"],"award-info":[{"award-number":["[2020SHFZ0039]"]}]},{"name":"Cuiying Scientific and Technological Innovation Program of Lanzhou University Second Hospital","award":["[No. CY2017-ZD01]"],"award-info":[{"award-number":["[No. CY2017-ZD01]"]}]},{"name":"the Key Project of Science and Technology in Gansu province","award":["[19ZD2WA001]"],"award-info":[{"award-number":["[19ZD2WA001]"]}]},{"name":"the Key Talents Project of Gansu Province","award":["[No. 2019RCXM020]"],"award-info":[{"award-number":["[No. 2019RCXM020]"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,12,14]]},"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Gastro-oesophageal reflux is common in patients with oesophagogastric junction (OGJ) cancer following radical surgery. We aim to conduct a systematic review to investigate the effectiveness and clinical value of additional antireflux surgery (pyloroplasty and fundoplication) for OGJ cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>\n                      We intend to search Medline, Cochrane Library and Embase databases for studies published in English, from database inception to October 2022. Randomised controlled trials and (non-random) controlled clinical trials will be eligible for inclusion. We will search for all eligible studies that have compared proximal gastrectomy plus additional antireflux surgery and proximal gastrectomy alone in patients with resectable OGJ cancer. All potential outcomes related to gastro-oesophageal reflux, including occurrence of reflux symptoms, reflux oesophagitis, reflux occurrence based on barium meal examination, pH of fluid from the lower oesophagus, and 24-hour oesophageal pH test will be assessed as the primary outcomes. Other outcomes, such as patients\u2019 survival and postoperative complications (eg, stenosis, infection and leak) will also be analysed. Two reviewers will independently screen the literature, extract data and assess the risk of bias in the included studies; subsequently, a meta-analysis will be performed using RevMan V.5.3 software to pool the results. The \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      and I\n                      <jats:sup>2<\/jats:sup>\n                      tests will be used for heterogeneity assessment and sources of heterogeneity will be explored using subgroup analysis. The Grading of Recommendations, Assessment, Development and Evaluation method will be applied to assess the level of evidence.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This proposed study is a secondary analysis of previously published data. Therefore, ethics approval is not required. The results will be presented for publication in a peer-reviewed journal and data will be stored in public databases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-066061","type":"journal-article","created":{"date-parts":[[2022,12,29]],"date-time":"2022-12-29T13:01:44Z","timestamp":1672318904000},"page":"e066061","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Effectiveness of additional antireflux surgery after resection of oesophagogastric junction cancer: protocol for a systematic review and meta-analysis"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4589-3717","authenticated-orcid":false,"given":"Na","family":"Wang","sequence":"first","affiliation":[{"name":"Second Clinical Medical College of Lanzhou University, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Zheng","sequence":"additional","affiliation":[{"name":"General Surgery Department, First Hospital of Lanzhou University, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2409-3681","authenticated-orcid":false,"given":"Yang","family":"Yu","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College of Lanzhou University, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Gao","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College of Lanzhou University, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"General Surgery Department Ward 5, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fanghui","family":"Ding","sequence":"additional","affiliation":[{"name":"General Surgery Department, First Hospital of Lanzhou University, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bofang","family":"Wang","sequence":"additional","affiliation":[{"name":"Second Clinical Medical College of Lanzhou University, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9741-9403","authenticated-orcid":false,"given":"Hao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Tumor Surgery, Lanzhou University Second Hospital, Lanzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2022,12,29]]},"reference":[{"key":"2025121602325857000_12.12.e066061.1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21492"},{"key":"2025121602325857000_12.12.e066061.2","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21262"},{"key":"2025121602325857000_12.12.e066061.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2003.11.056"},{"key":"2025121602325857000_12.12.e066061.4","unstructured":"M-y FU , Y-f Z , YAN Q . [Quality of life scores for esophageal and cardiac carcinoma after delaminated esophagogastrostomy]. Chinese J Clin Thor Cardiova Surg 2003;2."},{"key":"2025121602325857000_12.12.e066061.5","first-page":"444","article-title":"[Surgical treatment of gastric cardia cancer with fundoplication-a report of 193 cases]","volume":"17","author":"Cheng","year":"1995","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"2025121602325857000_12.12.e066061.6","unstructured":"Yuan H , O-Sen LS , Hai-Tian Z , et al . Application of Roux-en-Y gastrojejunostomy after proximal GA strectomy. Chinese J Bases Clinics Gen Surg 2003."},{"key":"2025121602325857000_12.12.e066061.7","first-page":"2025","article-title":"[Clinical effectiveness of pyloroplasty after proximal gastrectomy for cardiac carcinoma: a prospective randomizedcontrolled trial]","volume":"28","author":"Lin","year":"2012","journal-title":"J Pract Med"},{"key":"2025121602325857000_12.12.e066061.8","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1177\/145749690609500409","article-title":"Adenocarcinoma of the esophago-gastric junction","volume":"95","author":"Siewert","year":"2006","journal-title":"Scand J Surg"},{"key":"2025121602325857000_12.12.e066061.9","doi-asserted-by":"crossref","unstructured":"Higgins JP , Green S . Cochrane Handbook for systematic reviews of interventions. 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