{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T18:08:13Z","timestamp":1765735693447,"version":"3.48.0"},"reference-count":24,"publisher":"BMJ","issue":"2","license":[{"start":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T00:00:00Z","timestamp":1675382400000},"content-version":"unspecified","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,1,22]]},"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Non-alcoholic fatty liver disease (NAFLD) has become the most common chronic liver disorder over the last four decades, more evidence shows a high prevalence of sarcopenia in NAFLD that may influence disease severity. This meta-analysis aims to determine the association of sarcopenia with liver fibrosis and steatohepatitis in NAFLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>We will conduct the literature search using Medline (via PubMed), Web of Science databases, EMBASE, Cochrane Central Register of Controlled Trials and the Cochrane Database of Systematic Reviews (from the date of inception to 1 May 2022). There will be no restriction to the publication year. Two reviewers will independently screen the articles and abstract key study characteristics. The outcome of this meta-analysis is the strength of association of sarcopenia with liver fibrosis and steatohepatitis in NAFLD. The STATA (V.14, StataCorp, 2015) will be used to carry out the statistical analysis. Comprehensive evaluation of bias risk and heterogeneity will be performed before data synthesis. Also, consistency and evidence quality will be assessed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>There will be no need of ethics approval as this systematic review is summary and analysis of existing literature. Final results may be presented in international conferences or a peer-reviewed journal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD42022322685.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-066181","type":"journal-article","created":{"date-parts":[[2023,2,3]],"date-time":"2023-02-03T09:47:06Z","timestamp":1675417626000},"page":"e066181","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Association of sarcopenia with liver fibrosis and steatohepatitis in non-alcoholic fatty liver disease: protocol for a systematic review and meta-analysis"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6262-2102","authenticated-orcid":false,"given":"Zheng","family":"Wang","sequence":"first","affiliation":[{"name":"Department of General Surgery, Xuanwu Hospital Capital Medical University, Beijing, China"},{"name":"Beijing Municipal Geriatric Medical Research Center, Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saixin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Xuanwu Hospital Capital Medical University, Beijing, China"},{"name":"Beijing Municipal Geriatric Medical Research Center, Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Xuanwu Hospital Capital Medical University, Beijing, China"},{"name":"Beijing Municipal Geriatric Medical Research Center, Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Xuanwu Hospital Capital Medical University, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongbin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Xuanwu Hospital Capital Medical University, Beijing, China"},{"name":"Beijing Municipal Geriatric Medical Research Center, Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuo","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of General Surgery, Xuanwu Hospital Capital Medical University, Beijing, China"},{"name":"Beijing Municipal Geriatric Medical Research Center, Beijing, People's Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,2,3]]},"reference":[{"key":"2025121410063555000_13.2.e066181.1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-321611"},{"key":"2025121410063555000_13.2.e066181.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.08.018"},{"key":"2025121410063555000_13.2.e066181.3","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26716"},{"key":"2025121410063555000_13.2.e066181.4","doi-asserted-by":"publisher","DOI":"10.1097\/MCO.0b013e328333c1c1"},{"key":"2025121410063555000_13.2.e066181.5","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)32511-3"},{"key":"2025121410063555000_13.2.e066181.6","doi-asserted-by":"crossref","first-page":"1338","DOI":"10.1016\/j.dld.2020.07.004","article-title":"Association between liver fibrosis and appendicular skeletal muscle mass during antiviral therapy in chronic hepatitis B","volume":"52","author":"Kim","year":"2020","journal-title":"Dig Liver Dis"},{"key":"2025121410063555000_13.2.e066181.7","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1097\/MEG.0000000000001475","article-title":"Sarcopenia assessed using bioimpedance analysis is associated independently with significant liver fibrosis in patients with chronic liver diseases","volume":"32","author":"Hyun Kim","year":"2020","journal-title":"Eur J Gastroenterol Hepatol"},{"key":"2025121410063555000_13.2.e066181.8","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114520004559"},{"key":"2025121410063555000_13.2.e066181.9","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.g7647","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation","volume":"350","author":"Shamseer","year":"2015","journal-title":"BMJ"},{"key":"2025121410063555000_13.2.e066181.10","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24127"},{"key":"2025121410063555000_13.2.e066181.11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0166344","article-title":"Predictive values of the new sarcopenia index by the foundation for the National Institutes of health sarcopenia project for mortality among older Korean adults","volume":"11","author":"Moon","year":"2016","journal-title":"PLoS One"},{"key":"2025121410063555000_13.2.e066181.12","article-title":"Updated guidance for trusted systematic reviews: a new edition of the Cochrane Handbook for systematic reviews of interventions","volume":"10","author":"Cumpston","year":"2019","journal-title":"Cochrane Database Syst Rev"},{"key":"2025121410063555000_13.2.e066181.13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2010.04.026"},{"key":"2025121410063555000_13.2.e066181.14","doi-asserted-by":"crossref","first-page":"690","DOI":"10.1007\/s12350-015-0249-6","article-title":"An application of meta-analysis based on dersimonian and laird method","volume":"23","author":"George","year":"2016","journal-title":"J Nucl Cardiol"},{"key":"2025121410063555000_13.2.e066181.15","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.d4002","article-title":"Recommendations for examining and interpreting funnel plot asymmetry in meta-analyses of randomised controlled trials","volume":"343","author":"Sterne","year":"2011","journal-title":"BMJ"},{"key":"2025121410063555000_13.2.e066181.16","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.315.7109.629"},{"key":"2025121410063555000_13.2.e066181.17","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jhep.2016.08.019","article-title":"Sarcopenia is an independent risk factor for non-alcoholic steatohepatitis and significant fibrosis","volume":"66","author":"Koo","year":"2017","journal-title":"J Hepatol"},{"key":"2025121410063555000_13.2.e066181.18","doi-asserted-by":"publisher","DOI":"10.1111\/apt.13889"},{"key":"2025121410063555000_13.2.e066181.19","doi-asserted-by":"publisher","DOI":"10.1111\/apt.14843"},{"key":"2025121410063555000_13.2.e066181.20","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.043"},{"key":"2025121410063555000_13.2.e066181.21","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27368"},{"key":"2025121410063555000_13.2.e066181.22","doi-asserted-by":"crossref","first-page":"2230","DOI":"10.1002\/hep.30094","article-title":"Healthcare cost and utilization in nonalcoholic fatty liver disease: real-world data from a large U.S. claims database","volume":"68","author":"Allen","year":"2018","journal-title":"Hepatology"},{"key":"2025121410063555000_13.2.e066181.23","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28785"},{"key":"2025121410063555000_13.2.e066181.24","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22041917","article-title":"Sarcopenic obesity in liver cirrhosis: possible mechanism and clinical impact","volume":"22","author":"Nishikawa","year":"2021","journal-title":"Int J Mol Sci"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2022-066181","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,14]],"date-time":"2025-12-14T18:06:43Z","timestamp":1765735603000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2022-066181"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":24,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2023,2,3]]},"published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1136\/bmjopen-2022-066181"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2022-066181","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"type":"print","value":"2044-6055"},{"type":"electronic","value":"2044-6055"}],"subject":[],"published":{"date-parts":[[2023,2]]}}}