{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T03:59:35Z","timestamp":1765079975391,"version":"3.46.0"},"reference-count":24,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T00:00:00Z","timestamp":1684713600000},"content-version":"unspecified","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"EDCTP2","award":["RIA2020EF-2956-MA-CoV"],"award-info":[{"award-number":["RIA2020EF-2956-MA-CoV"]}]},{"name":"Centro de Excelencia Severo Ochoa","award":["2019-2023","CEX2018-000806-S"],"award-info":[{"award-number":["2019-2023","CEX2018-000806-S"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,4,26]]},"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Pregnant women are currently considered a vulnerable population to SARS-CoV-2 infection, with increased risk of severe COVID-19, preterm birth and maternal mortality. There is, however, a paucity of data on the burden of maternal SARS-CoV-2 infection in sub-Saharan countries. The objective of this study is to determine the prevalence and health effects of maternal SARS-CoV-2 infection in selected sites from Gabon and Mozambique.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>MA-CoV (MAternal CoVid) is an observational, multicentre prospective cohort study where 1000 pregnant women (500 per country) will be enrolled at the antenatal clinic visits. Participants will undergo monthly follow-up at each antenatal care visit, delivery and postpartum visit. The primary study outcome is the prevalence of SARS-CoV-2 infection during pregnancy. The clinical presentation of COVID-19 in pregnancy will also be characterised, and incidence of infection during pregnancy will be evaluated, as well as the risk factors of maternal and neonatal morbidity and mortality associated with SARS-CoV-2 infection and the risk of mother to child transmission of SARS-CoV-2. SARS-CoV-2 infection screening will be performed through PCR diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>\n                      The protocol was reviewed and approved by the\n                      <jats:italic>Comit\u00e9 National d\u2019\u00c9thique pour la Recherche au Gabon<\/jats:italic>\n                      ,\n                      <jats:italic>Comit\u00e9 Nacional de Bio\u00e9tica para Sa\u00fade de Mo\u00e7ambique<\/jats:italic>\n                      and the Ethics Committee of the Hospital Clinic of Barcelona (Spain). Project results will be presented to all stakeholders and published in open access journals.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT05303168\">NCT05303168<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-067083","type":"journal-article","created":{"date-parts":[[2023,5,22]],"date-time":"2023-05-22T10:46:19Z","timestamp":1684752379000},"page":"e067083","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Prevalence and impact of SARS-CoV-2 infection on maternal and infant health in African populations: protocol of a multicentre prospective cohort study (MA-CoV project)"],"prefix":"10.1136","volume":"13","clinical-trial-number":[{"clinical-trial-number":"nct05303168","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct03671109","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct05303168","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4682-1421","authenticated-orcid":false,"given":"Ant\u00eda","family":"Figueroa-Romero","sequence":"first","affiliation":[{"name":"Maternal, Child and Reproductive Health Initiative, Barcelona Institute for Global Health, Barcelona, Spain"},{"name":"CIBERESP, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anete","family":"Mendes","sequence":"additional","affiliation":[{"name":"Centro de Investiga\u00e7\u00e3o em Sa\u00fade de Manhi\u00e7a, Manhi\u00e7a, 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