{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T17:51:44Z","timestamp":1793987504402,"version":"4.8.0"},"reference-count":23,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T00:00:00Z","timestamp":1671494400000},"content-version":"unspecified","delay-in-days":19,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2022,12,6]]},"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Pre-exposure prophylaxis (PrEP) is effective for HIV prevention and is mostly used by men who have sex with men (MSM). The aim of this study was to describe the characteristics of a cohort of PrEP users at first PrEP counselling visits (baseline, BL).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross-sectional study of a cohort of MSM receiving PrEP (Centro San Luigi, CSL-PrEP Cohort).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Secondary-level sexually transmitted infections (STI) centre in Milan, Italy, from May 2017 to May 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Overall, 624 MSM PrEP users were included; most users were Caucasian (97%), attended university (64%), with a median BL age of 34.5 years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 45% choose the daily-based PrEP regimen, 55% the event-based one. An increasing trend in PrEP counselling visits was observed (p=0.024). The majority had between 10 and 19 partners in the 3 months before BL and 41% were chemsex users. All had a HIV Incidence Risk Index for MSM (HIRI-MSM)&gt;10, 54% between 20 and 29. Overall, 50% had \u22651 previous STI and 22% \u22651\u2009BL STI. BL chlamydia (10%) was often more frequent than in the past (7%). The number of sexual partners was associated with BL chlamydia (p&lt;0.001), gonorrhoea (p=0.002) and syphilis (p=&lt;0.001), HIRI-MSM with chlamydia (p=0.001) and gonorrhoea (p=0.008), chemsex use with chlamydia (p=0.003) and gonorrhoea (p=0.030).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>We observed an unbalanced access to PrEP in respect to all key populations which might benefit from PrEP, with a similar choice for event-based or daily-based regimens. High-risk behaviours and STIs were frequently observed. History of chlamydia was very frequently high in asymptomatic MSM at BL, compared with what observed before access to PrEP. High-risk behaviours and HIRI-MSM were associated with most of STIs.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-067261","type":"journal-article","created":{"date-parts":[[2022,12,20]],"date-time":"2022-12-20T09:56:29Z","timestamp":1671530189000},"page":"e067261","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Characteristics of HIV pre-exposure prophylaxis users at first PrEP counselling visit: the CSL-PrEP cohort"],"prefix":"10.1136","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2673-2731","authenticated-orcid":false,"given":"Silvia","family":"Nozza","sequence":"first","affiliation":[{"name":"Infectious Diseases Unit, San Raffaele Hospital, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7811-6255","authenticated-orcid":false,"given":"Angelo Roberto","family":"Raccagni","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Vita-Salute San Raffaele University, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Lolatto","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, San Raffaele Hospital, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniele","family":"Ceccarelli","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, San Raffaele Hospital, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Galli","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, San Raffaele Hospital, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Alberton","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Vita-Salute San Raffaele University, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Bruzzesi","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Vita-Salute San Raffaele University, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Canetti","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, San Raffaele Hospital, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"Strano","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Vita-Salute San Raffaele University, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Ripa","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, San Raffaele Hospital, Milano, Italy"},{"name":"Infectious Diseases Unit, Vita-Salute San Raffaele University, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Costanza","family":"Bertoni","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, Vita-Salute San Raffaele University, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonella","family":"Castagna","sequence":"additional","affiliation":[{"name":"Infectious Diseases Unit, San Raffaele Hospital, Milano, Italy"},{"name":"Infectious Diseases Unit, Vita-Salute San Raffaele University, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2022,12,20]]},"reference":[{"key":"2025120618074390000_12.12.e067261.1","unstructured":"ECDC . Hiv\/Aids surveillance in Europe 2021, 2021. Available: https:\/\/www.ecdc.europa.eu\/en\/publications-data\/hiv-aids-surveillance-europe-2021-2020-data [Accessed 01 July 2022]."},{"key":"2025120618074390000_12.12.e067261.2","unstructured":"Istituto Superiore di Sanit . Notiziario dell\u2019ISS (Volume 33 - Numero 11 2020) - Aggiornamento delle nuove diagnosi di infezione da HIV e dei casi di AIDS in Italia al. Available: https:\/\/www.epicentro.iss.it\/aids\/notiziario-coa [Accessed 10 Nov 2022]."},{"key":"2025120618074390000_12.12.e067261.3","doi-asserted-by":"crossref","first-page":"e554-e562","DOI":"10.1016\/S2352-3018(22)00133-3","article-title":"Daily and on-demand HIV pre-exposure prophylaxis with emtricitabine and tenofovir disoproxil (ANRS PREVENIR): a prospective observational cohort study","volume":"9","author":"Molina","year":"2022","journal-title":"Lancet HIV"},{"key":"2025120618074390000_12.12.e067261.4","first-page":"131","article-title":"Treatment as prevention for HIV infection: current data, challenges, and global perspectives","volume":"20","author":"Yombi","year":"2018","journal-title":"AIDS Rev"},{"key":"2025120618074390000_12.12.e067261.5","doi-asserted-by":"publisher","DOI":"10.1007\/s10461-020-02855-9"},{"key":"2025120618074390000_12.12.e067261.6","doi-asserted-by":"crossref","DOI":"10.1002\/jia2.25953","article-title":"Prep user profiles, dynamics of PreP use and follow-up: a cohort analysis at a Belgian HIV centre (2017-2020)","volume":"25","author":"Rotsaert","year":"2022","journal-title":"J Int AIDS Soc"},{"key":"2025120618074390000_12.12.e067261.7","doi-asserted-by":"crossref","first-page":"e529","DOI":"10.1016\/S2468-2667(22)00106-2","article-title":"Real-World effectiveness of pre-exposure prophylaxis in men at high risk of HIV infection in France: a nested case-control study","volume":"7","author":"Jourdain","year":"2022","journal-title":"Lancet Public Health"},{"key":"2025120618074390000_12.12.e067261.8","unstructured":"Italian Conference on AIDS and Antiviral Research . ICAR 2022, Bergamo. Falaguasta M. PreP in Italy: how many people access it and what kind of services are offered? Available: https:\/\/www.icar2022.it\/download\/AbstractBook.pdf [Accessed 10 Nov 2022]."},{"key":"2025120618074390000_12.12.e067261.9","doi-asserted-by":"crossref","DOI":"10.1136\/sextrans-2022-055447","article-title":"High prevalence of anal papillomavirus infection in men who have sex with men PreP users","author":"Rossotti","year":"2022","journal-title":"Sex Transm Infect"},{"key":"2025120618074390000_12.12.e067261.10","unstructured":"Italian Conference on AIDS and Antiviral Research . ICAR 2022, Bergamo. Vinti P. long-term follow-up in a community-based PreP cohort: controlled increase in risk exposure. Available: https:\/\/www.icar2022.it\/download\/AbstractBook.pdf [Accessed 10 Nov 2022]."},{"key":"2025120618074390000_12.12.e067261.11","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugpo.2018.11.014"},{"key":"2025120618074390000_12.12.e067261.12","doi-asserted-by":"crossref","DOI":"10.1136\/sextrans-2021-055215","article-title":"Chemsex and incidence of sexually transmitted infections among Canadian pre-exposure prophylaxis (PreP) users in the l'Actuel PreP cohort (2013-2020)","volume":"98","author":"Flores Anato","year":"2022","journal-title":"Sex Transm Infect"},{"key":"2025120618074390000_12.12.e067261.13","doi-asserted-by":"crossref","first-page":"4055","DOI":"10.1007\/s10461-022-03730-5","article-title":"Chemsex practices in PreP: beyond addiction and risk toward a healthy sex Life-Baseline experiences from a hospital-based PreP program in Barcelona, Spain","volume":"26","author":"De La Mora","year":"2022","journal-title":"AIDS Behav"},{"key":"2025120618074390000_12.12.e067261.14","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2019.2947"},{"key":"2025120618074390000_12.12.e067261.15","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e318256b2f6"},{"key":"2025120618074390000_12.12.e067261.16","unstructured":"Ministero della Salute . Linee guida italiane HIV, 2017. Available: https:\/\/www.salute.gov.it\/imgs\/C_17_pubblicazioni_2696_allegato.pdf [Accessed 10 Nov 2022]."},{"key":"2025120618074390000_12.12.e067261.17","unstructured":"European AIDS Clinical Society . EACS guidelines. Available: https:\/\/www.eacsociety.org\/guidelines\/eacs-guidelines\/. [Accessed 10 Nov 2022]."},{"key":"2025120618074390000_12.12.e067261.18","unstructured":"ECDC . Around half a million men who have sex with men in the EU need PrEP but cannot access it, 2019. Available: https:\/\/www.ecdc.europa.eu\/en\/news-events\/around-half-million-men-who-have-sex-men-eu-need-prep-cannot-access-it [Accessed 01 July 2022]."},{"key":"2025120618074390000_12.12.e067261.19","doi-asserted-by":"crossref","first-page":"e222","DOI":"10.1097\/QAI.0000000000002659","article-title":"Hiv prevention responsibility beliefs among men who have sex with men in the PreP era","volume":"87","author":"Truong","year":"2021","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2025120618074390000_12.12.e067261.20","doi-asserted-by":"crossref","DOI":"10.4414\/SMW.2022.w30192","article-title":"Changes in mental and sexual health among MSM using HIV pre-exposure prophylaxis during the SARS-CoV-2 pandemic: longitudinal analysis of the SwissPrEPared cohort study","volume":"152","author":"Winter","year":"2022","journal-title":"Swiss Med Wkly"},{"key":"2025120618074390000_12.12.e067261.21","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1007\/s10461-021-03195-y","article-title":"COVID-19 pandemic, pre-exposure prophylaxis (PreP) care, and HIV\/STI testing among patients receiving care in three HIV epidemic priority states","volume":"25","author":"Hill","year":"2021","journal-title":"AIDS Behav"},{"key":"2025120618074390000_12.12.e067261.22","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1097\/QAI.0000000000002472","article-title":"Pre-Exposure prophylaxis uptake among men who have sex with men who used nPEP: a longitudinal analysis of attendees at a large sexual health clinic in Montr\u00e9al (Canada)","volume":"85","author":"Xia","year":"2020","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2025120618074390000_12.12.e067261.23","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2020-048478"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2022-067261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,7]],"date-time":"2025-12-07T02:07:55Z","timestamp":1765073275000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2022-067261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":23,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2022,12,20]]},"published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1136\/bmjopen-2022-067261"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2022-067261","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12]]}}}