{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:24:57Z","timestamp":1780089897128,"version":"3.54.0"},"reference-count":34,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"unspecified","delay-in-days":22,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"FWO","award":["12Y2420N"],"award-info":[{"award-number":["12Y2420N"]}]},{"DOI":"10.13039\/100015756","name":"Janssen-Cilag","doi-asserted-by":"crossref","award":["chair \u2018Value In Psoriasis\u2019"],"award-info":[{"award-number":["chair \u2018Value In Psoriasis\u2019"]}],"id":[{"id":"10.13039\/100015756","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/100004336","name":"Novartis","doi-asserted-by":"publisher","award":["Novartis Research Collaboration"],"award-info":[{"award-number":["Novartis Research Collaboration"]}],"id":[{"id":"10.13039\/100004336","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,5,2]]},"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Currently, the healthcare sector is under tremendous financial pressure, and many acknowledge that a dramatic shift is required as the current system is not sustainable. Furthermore, the quality of care that is delivered varies strongly. Several solutions have been proposed of which the conceptual framework known as value-based healthcare (VBHC) is further explored in this study for psoriasis. Psoriasis is a chronic inflammatory skin disease, which is associated with a high disease burden and high treatment costs. The objective of this study is to investigate the feasibility of using the VBHC framework for the management of psoriasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This is a prospective clinical study in which new patients attending the psoriasis clinic (PsoPlus) of the Ghent University Hospital will be followed up during a period of 1\u2009year. The main outcome is to determine the value created for psoriasis patients. The created value will be considered as a reflection of the evolution of the value score (ie, the weighted outputs (outcomes) divided by weighted inputs (costs)) obtained using data envelopment analysis. Secondary outcomes are related to comorbidity control, outcome evolution and treatment costs. In addition, a bundled payment scheme will be determined as well as potential improvements in the treatment process. A total of 350 patients will be included in this trial and the study initiation is foreseen on 1 March 2023.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This study has been approved by the Ethics Committee of the Ghent University Hospital. The findings of this study will be disseminated by various means: (1) publication in one or more peer-reviewed dermatology and\/or management journals, (2) (inter)national congresses, (3) via the psoriasis patient community and (4) through the research team\u2019s social media channels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT05480917\">NCT05480917<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-067504","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T11:05:26Z","timestamp":1684839926000},"page":"e067504","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Value in psoriasis (IRIS) trial: implementing value-based healthcare in psoriasis management \u2013 a 1-year prospective clinical study to evaluate feasibility and value creation"],"prefix":"10.1136","volume":"13","clinical-trial-number":[{"clinical-trial-number":"nct05480917","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct05480917","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5355-6235","authenticated-orcid":false,"given":"Niels","family":"Hilhorst","sequence":"first","affiliation":[{"name":"Dermatology Research Unit (DRU), Ghent University, Ghent, Belgium"},{"name":"Department of Dermatology, University Hospital Ghent, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3194-3231","authenticated-orcid":false,"given":"Erin","family":"Roman","sequence":"additional","affiliation":[{"name":"Health Care Management Centre, Vlerick Business School, Ghent, Belgium"},{"name":"Faculty of Economics and Business, Catholic University of Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joke","family":"Borz\u00e9e","sequence":"additional","affiliation":[{"name":"Health Care Management Centre, Vlerick Business School, Ghent, Belgium"},{"name":"Faculty of Economics and Business, Catholic University of Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elfie","family":"Deprez","sequence":"additional","affiliation":[{"name":"Dermatology Research Unit (DRU), Ghent University, Ghent, Belgium"},{"name":"Department of Dermatology, University Hospital Ghent, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Hoorens","sequence":"additional","affiliation":[{"name":"Dermatology Research Unit (DRU), Ghent University, Ghent, Belgium"},{"name":"Department of Dermatology, University Hospital Ghent, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brecht","family":"Cardoen","sequence":"additional","affiliation":[{"name":"Health Care Management Centre, Vlerick Business School, Ghent, Belgium"},{"name":"Faculty of Economics and Business, Catholic University of Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1102-3684","authenticated-orcid":false,"given":"Filip","family":"Roodhooft","sequence":"additional","affiliation":[{"name":"Faculty of Economics and Business, Catholic University of Leuven, Leuven, Belgium"},{"name":"Accounting and Finance, Vlerick Business School, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Lambert","sequence":"additional","affiliation":[{"name":"Dermatology Research Unit (DRU), Ghent University, Ghent, Belgium"},{"name":"Department of Dermatology, University Hospital Ghent, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"2025121401102916000_13.5.e067504.1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-4-200302180-00006"},{"key":"2025121401102916000_13.5.e067504.2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-138-4-200302180-00007"},{"key":"2025121401102916000_13.5.e067504.3","doi-asserted-by":"publisher","DOI":"10.1001\/jama.299.20.2406"},{"key":"2025121401102916000_13.5.e067504.4","unstructured":"World Health Organization . 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