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Of these, 203 used diuretics (27.1% thiazide alone, 70.0% thiazide\/non-diuretic combinations) and 349 used non-diuretics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>Switching the established antihypertensive from morning to bedtime, and comparing the experience of diuretic and non-diuretic users.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>Primary outcome: Adherence to bedtime allocation time at 6\u2009months (defined as the willingness to continue with bedtime use, not an assessment of missed doses). Secondary 6-month outcomes: (1) nocturia considered to be a major burden and (2) increase in overnight urinations\/week. All outcomes were self-reported and additionally collected at 6\u2009weeks.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>At 6\u2009months: Adherence to bedtime allocation time was lower in diuretic users than non-diuretic users (77.3% vs 89.8%; difference 12.6%; 95%\u2009CI 5.8% to 19.8%; p&lt;0.0001; NNH 8.0), and more diuretic users considered nocturia a major burden (15.6% vs 1.3%; difference 14.2%; 95%\u2009CI 8.9% to 20.6%; p&lt;0.0001; NNH 7.0). Compared with baseline, diuretic users experienced 1.0 more overnight urinations\/week (95%\u2009CI 0.0 to 1.75; p=0.01). Results did not differ between sexes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Switching diuretics to bedtime did promote nocturia, but only 15.6% found nocturia a major burden. At 6\u2009months, 77.3% of diuretic users were adherent to bedtime dosing. Bedtime diuretic use is viable for many hypertensive patients, should it ever become clinically indicated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT02990663\">NCT02990663<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-068188","type":"journal-article","created":{"date-parts":[[2023,6,7]],"date-time":"2023-06-07T03:55:23Z","timestamp":1686110123000},"page":"e068188","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Tolerability of bedtime diuretics: a prospective cohort 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