{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T13:37:45Z","timestamp":1782999465250,"version":"3.54.5"},"reference-count":49,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T00:00:00Z","timestamp":1682985600000},"content-version":"unspecified","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Sichuan Province Science and Technology Plan Project","award":["2020YFS0035"],"award-info":[{"award-number":["2020YFS0035"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,3,30]]},"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>For improving and optimising drug use in children, we previously developed a tool (including a series of criteria for identifying potentially inappropriate prescribing in children) by literature review and the two-round Delphi technique to prevent inappropriate medication prescriptions at the prescribing stage.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the prevalence of potentially inappropriate prescription (PIP) among hospitalised children and explore risk factors associated with PIP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A retrospective cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>A tertiary children\u2019s hospital in China.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Hospitalised children with complete medical records who received drug treatment and discharged from 1 January to 31 December 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome measures<\/jats:title>\n                    <jats:p>We evaluated the medication prescriptions by using a series of previously developed criteria for detecting the prevalence of PIP in hospitalised children and used logistic regression to explore the risk factors (including sex, age, number of drugs, number of comorbidities, days of hospitalisation and admission departments) for PIP in children.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 87\u2009555 medication prescriptions for 16\u2009995 hospitalised children were analysed, and 19 722 PIPs were detected. The prevalence of PIP was 22.53%, and 36.92% of the children had at least one PIP during hospitalisation. The department with the highest prevalence of PIP was the surgical department (OR 9.413; 95%\u2009CI 5.521 to 16.046), followed by the paediatric intensive care unit (PICU; OR 8.206; 95%\u2009CI 6.643 to 10.137). \u2018Inhaled corticosteroids for children with respiratory infections but without chronic respiratory diseases\u2019 was the most frequent PIP. Logistic regression results showed that PIP was more likely to occur in male patients (OR 1.128, 95%\u2009CI 1.059 to 1.202) and younger patients (&lt;2 years old; OR 1.974; 95%\u2009CI 1.739 to 2.241), and in those with more comorbidities (\u226511 types; OR 4.181; 95%\u2009CI 3.671 to 4.761), concomitant drugs (\u226511 types; OR 22.250; 95%\u2009CI 14.468 to 34.223) or longer hospital stay (\u226530 days; OR 8.130; 95%\u2009CI 6.727 to 9.827).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Medications for long-term hospitalised young children with multiple comorbidities should be minimised and optimised, to avoid PIP, reduce adverse drug reactions and ensure children\u2019s medication safety. The surgery department and PICU had a high prevalence of PIP in the studied hospital and should be the focus of supervision and management in routine prescription review.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-068680","type":"journal-article","created":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T11:19:02Z","timestamp":1683026342000},"page":"e068680","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Potentially inappropriate prescribing in hospitalised children: a retrospective, cross-sectional study at a tertiary children\u2019s hospital in China"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0027-5296","authenticated-orcid":false,"given":"Siyu","family":"Li","sequence":"first","affiliation":[{"name":"Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China"},{"name":"Evidence-based Pharmacy Center, 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Education, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dan","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Birth Defects and Related Diseases of Women and Children, West China Second University Hospital, Sichuan University, Ministry of Education, Chengdu, China"},{"name":"Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi-Jun","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China"},{"name":"Evidence-based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, China"},{"name":"NMPA Key Laboratory for Technical Research on Drug Products In Vitro and In Vivo Correlation, West China Second University Hospital, Sichuan University, Chengdu, China"},{"name":"Key Laboratory 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