{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T23:16:26Z","timestamp":1792624586517,"version":"4.5.0"},"reference-count":52,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T00:00:00Z","timestamp":1692144000000},"content-version":"unspecified","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011729","name":"Abbeyfield Research Foundation","doi-asserted-by":"publisher","award":["472"],"award-info":[{"award-number":["472"]}],"id":[{"id":"10.13039\/100011729","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,8,1]]},"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Ocular pain is a commonly reported finding in the intravitreal injection procedure, but post-injection experiences and patient adherence to treatment remain underexplored. We therefore aimed to identify key variations in the intravitreal injection procedure that may influence pain, and to gain insights into the post-injection experience and treatment adherence from the perspective of patients and practitioners.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Qualitative semistructured interview study using reflexive thematic analysis of transcripts.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Hospital Eye Clinic in Wales, UK. Interviews were conducted between May and September 2019.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>Purposive sample of patients aged \u226550 years with neovascular age-related macular degeneration and no other retinal pathology who had received at least six intravitreal injections, and practitioners including ophthalmologists, registered nurses and optometrists who performed intravitreal injections at the research site.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Data saturation was reached with 21 interviews: 14 patients and 7 practitioners. Three main themes were identified from the analysis: fear of losing eyesight and treatment anxiety influence patient adherence to treatment, variability in pain experience during treatment, and post-injection experience and impact on patient recovery. To reassure patients feeling apprehensive about the injections, practitioners promoted safety and trust, and used techniques to manage anxiety. Key variations that may influence pain identified were application of antiseptic or anaesthetic, injecting methods and communication. During injection, patients reported a dull-aching and sharp pain, contrary to practitioners\u2019 perspective of feeling a \u2018pressure\u2019. Patients described prolonged soreness and irritation of up to 36 hours post-injection affecting their sleep and recovery.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Establishing rapport supported patients to recognise the necessity of ongoing treatment to prevent sight loss; however, inadequate pain management led to undesirable outcomes. Practitioners should use pain assessment tools during and immediately after injection and provide ongoing consistent information to help patients manage pain at home.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-069625","type":"journal-article","created":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T13:28:54Z","timestamp":1692192534000},"page":"e069625","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":14,"title":["Pain related to intravitreal injections for age-related macular degeneration: a qualitative study of the perspectives of patients and practitioners"],"prefix":"10.1136","volume":"13","author":[{"given":"Christina","family":"Yiallouridou","sequence":"first","affiliation":[{"name":"School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0347-7651","authenticated-orcid":false,"given":"Jennifer H","family":"Acton","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjiv","family":"Banerjee","sequence":"additional","affiliation":[{"name":"Ophthalmology, Cardiff and Vale University Health Board, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heather","family":"Waterman","sequence":"additional","affiliation":[{"name":"Healthcare Sciences, Cardiff University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9312-6184","authenticated-orcid":false,"given":"Ashley","family":"Wood","sequence":"additional","affiliation":[{"name":"School of Optometry and Vision Sciences, Cardiff University, Cardiff, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,8,16]]},"reference":[{"key":"2025120523515005000_13.8.e069625.1","doi-asserted-by":"publisher","DOI":"10.1016\/S2214-109X(13)70145-1"},{"key":"2025120523515005000_13.8.e069625.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.06.018"},{"key":"2025120523515005000_13.8.e069625.3","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-011504","article-title":"How does age-related macular degeneration affect real-world visual ability and quality of life? 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