{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T13:26:55Z","timestamp":1777728415501,"version":"3.51.4"},"reference-count":84,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T00:00:00Z","timestamp":1683676800000},"content-version":"unspecified","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,4,28]]},"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Ankle sprains are common in sports and the general population. Although considered innocuous, a large proportion has residual complaints such as recurrent ankle sprains and develop chronic ankle instability. Although some predicting factors are identified, there is no unequivocality regarding the development of chronic ankle instability, nor about the optimal rehabilitation for an acute ankle sprain. Alongside the biomechanical impairments, ankle sprains are a burden on society due to substantial economic costs. Therefore, we aim to identify key clinical predictors of chronic ankle instability or recovery after acute lateral ankle sprain. Additionally, we aim to determine cost-of-illness of patients who developed chronic ankle instability.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>\n                      This prospective cohort study (Clinicaltrials.gov:\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT05637008\">NCT05637008<\/jats:ext-link>\n                      - pre-results) aims to recruit adult (18\u201355 years) patients with an acute lateral ankle sprain who are active in sports. Clinical assessments and patient-reported outcome measures will be used to collect data at 7\u201314 days, 6 weeks, 12 weeks and 12 months after enrolment in the study. The primary outcome will be chronic ankle instability at 12-month follow-up. Salient outcomes will be analysed by logistic regression to determine association with the development of chronic ankle instability. Participants will fill in a cost diary containing direct and indirect costs related to their injury.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and disseminations<\/jats:title>\n                    <jats:p>The ethical committee of the Antwerp University Hospital (B3002022000138) has given approval of the protocol and consent forms on 10 October 2022. We perform this study according to the Helsinki Declaration. We will present results at conferences or webinars and publish in peer-reviewed articles.<\/jats:p>\n                    <jats:p>NCT05637008.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-069867","type":"journal-article","created":{"date-parts":[[2023,5,10]],"date-time":"2023-05-10T13:35:26Z","timestamp":1683725726000},"page":"e069867","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":12,"title":["Determining key clinical predictors for chronic ankle instability and return to sports with cost of illness analysis: protocol of a prospective cohort study"],"prefix":"10.1136","volume":"13","clinical-trial-number":[{"clinical-trial-number":"nct05637008","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct05637008","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7856-463X","authenticated-orcid":false,"given":"Jente","family":"Wagemans","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Sciences and Physiotherapy, University of Antwerp, Antwerpen, Belgium"},{"name":"Department of Physiotherapy, Bern University of Applied Sciences, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Taeymans","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Bern University of Applied Sciences, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin","family":"Kuppens","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences and Physiotherapy, University of Antwerp, Antwerpen, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heiner","family":"Baur","sequence":"additional","affiliation":[{"name":"Department of Physiotherapy, Bern University of Applied Sciences, Bern, Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Bleakley","sequence":"additional","affiliation":[{"name":"School of Health Sciences, Faculty of Life and Health Science, Ulster University, Newtownabbey, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Vissers","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Sciences and Physiotherapy, University of Antwerp, Antwerpen, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,5,10]]},"reference":[{"key":"2025121601091954000_13.5.e069867.1","doi-asserted-by":"crossref","unstructured":"Canata GL , d\u2019Hooghe P , Hunt KJ , et al . 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