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However, the evidence supporting MWM efficacy for improving shoulder range of motion (ROM) and pain in patients with RCRSP is limited. It is also unclear whether higher volume MWM leads to better clinical outcomes compared with lower volume MWM in patients with RCRSP. The primary aim of this study is to assess the effect of MWM on the angular onset of pain during shoulder abduction in patients with RCRSP.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>Sixty participants with RCRSP will be randomised to receive either MWM or sham MWM intervention. The primary outcome is the angular onset of pain during shoulder abduction, and secondary outcomes are pain intensity at the angular onset of pain during shoulder abduction, maximum shoulder ROM, pain intensity during maximum shoulder abduction, pressure pain threshold, mechanical temporal summation, global rating of change scale (GROC) and Brief Pain Inventory-Short Form (BPI-SF). The angular onset of pain and the pain intensity at that range will be assessed at baseline, after 1 set and 3 sets of 10 repetitions of MWM or sham MWM. The GROC will be measured immediately after receiving 3 sets of interventions and on day 3 after interventions. The BPI-SF will be measured on days 1, 3, 5 and 7 after interventions. Other secondary outcomes will be assessed at baseline and after 3 sets of interventions. A linear mixed effects model with a random intercept will be used to compare changes in the outcome measures between MWM and sham MWM interventions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This study has been approved by the University of Otago Ethics Committee (Ref. H21\/117). Findings from this study will be disseminated through presentations at international and national conferences and will be submitted for publication in a peer-reviewed journal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>ACTRN 12621001723875.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-069919","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T13:21:02Z","timestamp":1691587262000},"page":"e069919","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Initial effect of high-volume mobilisation with movement on shoulder range of motion and pain in patients with rotator cuff-related shoulder pain: protocol for a randomised controlled trial (Evolution Trial)"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9274-3447","authenticated-orcid":false,"given":"Sizhong","family":"Wang","sequence":"first","affiliation":[{"name":"Centre for Health, Activity and Rehabilitation Research (CHARR) - School of Physiotherapy, University of Otago, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Preventive and Social Medicine, University of Otago, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy M","family":"Chapple","sequence":"additional","affiliation":[{"name":"Centre for Health, Activity and Rehabilitation Research (CHARR) - School of Physiotherapy, University of Otago, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramakrishnan","family":"Mani","sequence":"additional","affiliation":[{"name":"Centre for Health, Activity and Rehabilitation Research (CHARR) - School of Physiotherapy, University of Otago, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9287-9187","authenticated-orcid":false,"given":"Daniel C","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Centre for Health, Activity and Rehabilitation Research (CHARR) - School of Physiotherapy, University of Otago, Dunedin, New Zealand"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"2025121411510790000_13.8.e069919.1","doi-asserted-by":"publisher","DOI":"10.1080\/03009740310004667"},{"key":"2025121411510790000_13.8.e069919.2","first-page":"519","article-title":"Shoulder disorders in general practice: prognostic indicators of outcome","volume":"46","author":"van der Windt","year":"1996","journal-title":"Br J Gen Pract"},{"key":"2025121411510790000_13.8.e069919.3","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/38.2.160"},{"key":"2025121411510790000_13.8.e069919.4","doi-asserted-by":"crossref","DOI":"10.1186\/s13075-016-1002-5","article-title":"Exercise therapy after ultrasound-guided corticosteroid injections in patients with subacromial pain syndrome: a randomized controlled trial","volume":"18","author":"Ellegaard","year":"2016","journal-title":"Arthritis Res Ther"},{"key":"2025121411510790000_13.8.e069919.5","doi-asserted-by":"publisher","DOI":"10.3109\/17453674.2014.920991"},{"key":"2025121411510790000_13.8.e069919.6","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1177\/1758573215576456","article-title":"Subacromial shoulder pain","volume":"7","author":"Kulkarni","year":"2015","journal-title":"Shoulder Elbow"},{"key":"2025121411510790000_13.8.e069919.7","unstructured":"Hing W , Hall T , Mulligan B . 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