{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T15:11:57Z","timestamp":1790953917279,"version":"4.1.0"},"reference-count":45,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:00:00Z","timestamp":1696982400000},"content-version":"unspecified","delay-in-days":10,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"The Health & Medical Care Committee of the Regional Executive Board of the Region V\u00e4strag\u00f6talands region","award":["VGFOUREG-86294, VGFOUREG-969459, ALFGBG-966255, AL"],"award-info":[{"award-number":["VGFOUREG-86294, VGFOUREG-969459, ALFGBG-966255, AL"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background and objectives<\/jats:title>\n                    <jats:p>While alcohol consumption is associated with common risk factors for diastolic dysfunction the independent impact of low levels of alcohol consumption on this condition in a community setting is still unclear.<\/jats:p>\n                    <jats:p>Thus, the aim of this study was to explore this association in a representative population sample employing optimal echocardiographic techniques.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross-sectional observational study in community-based population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Settings, participants and methods<\/jats:title>\n                    <jats:p>\n                      Participants between 30 and 75 years of age were consecutively invited to a physical examination, interview, conventional echocardiography, including Tissue Velocity Imaging. Diastolic dysfunction was defined according to the European Society of Cardiology criteria, excluding subjects with ejection fraction &lt;45%, self-reported history of heart failure or atrial fibrillation on ECG. Self-reported alcohol intake using a validated questionnaire was categorised as\n                      <jats:italic>no intake, low and medium-high<\/jats:italic>\n                      intake.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      In total, 500 men and 538\u2009women (mean age 55.4\u00b113) were successfully examined. Diastolic dysfunction was identified in 16% (79\/500) of the men and 13% (58\/538) of the women. The multivariable adjusted model revealed a strong and independent association between alcohol intake and diastolic dysfunction. In fact, using no alcohol intake as reference, diastolic dysfunction was independently associated with alcohol consumption in a dose-dependent fashion;\n                      <jats:italic>low consumption,<\/jats:italic>\n                      OR 2.3 (95% CI 1.3 to 4.0) and\n                      <jats:italic>medium-high consumption<\/jats:italic>\n                      OR 3.1 (95% CI 1.6 to 6.2), respectively.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>There was a significant association between alcohol consumption and diastolic dysfunction starting already at low levels that was supported by a dose-dependent pattern. These results need confirmatory studies and are important in public health policies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-069937","type":"journal-article","created":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T12:17:35Z","timestamp":1697026655000},"page":"e069937","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Association between self-reported alcohol consumption and diastolic dysfunction: a cross-sectional study"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7722-1528","authenticated-orcid":false,"given":"Bledar","family":"Daka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise","family":"Bennet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lennart","family":"R\u00e5stam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margareta I","family":"Hellgren","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Magnusson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Lindblad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,10,11]]},"reference":[{"key":"2024021510551646000_13.10.e069937.1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.106.661868"},{"key":"2024021510551646000_13.10.e069937.2","unstructured":"World Health Organization . 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