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Exercise interventions, such as locomotor training (LT), can promote sensorimotor and autonomic recovery post SCI. Recently, breakthroughs in SCI research have reported beneficial effects of electrical spinal cord stimulation (SCS) on motor and autonomic functions. Despite literature supporting the independent benefits of transcutaneous SCS (TSCS) and LT, the effect of pairing TSCS with LT is unknown. These therapies are non-invasive, customisable and have the potential to simultaneously benefit both sensorimotor and autonomic functions. The aim of this study is to assess the effects of LT paired with TSCS in people with chronic SCI on outcomes of sensorimotor and autonomic function.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>Twelve eligible participants with chronic (&gt;1 year) motor-complete SCI, at or above the sixth thoracic segment, will be enrolled in this single-blinded, randomised sham-controlled trial. Participants will undergo mapping for optimisation of stimulation parameters and baseline assessments of motor and autonomic functions. Participants will then be randomly assigned to either LT+TSCS or LT+Sham stimulation for 12 weeks, after which postintervention assessments will be performed to determine the effect of TSCS on motor and autonomic functions. The primary outcome of interest is attempted voluntary muscle activation using surface electromyography. The secondary outcomes relate to sensorimotor function, cardiovascular function, pelvic organ function and health-related quality of life. Statistical analysis will be performed using two-way repeated measures Analysis of variance (ANOVAs) or Kruskal-Wallis and Cohen\u2019s effect sizes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This study has been approved after full ethical review by the University of British Columbia\u2019s Research Ethics Board. The stimulator used in this trial has received Investigation Testing Authorisation from Health Canada. Trial results will be disseminated through peer-reviewed publications, conference presentations and seminars.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT04726059\">NCT04726059<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-070544","type":"journal-article","created":{"date-parts":[[2023,7,14]],"date-time":"2023-07-14T11:17:17Z","timestamp":1689333437000},"page":"e070544","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Motor and autonomic concomitant health improvements with neuromodulation and exercise (MACHINE) training: a randomised controlled trial in individuals with spinal cord injury"],"prefix":"10.1136","volume":"13","clinical-trial-number":[{"clinical-trial-number":"nct04726059","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5042-1490","authenticated-orcid":false,"given":"Claire","family":"Shackleton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3796-8085","authenticated-orcid":false,"given":"Soshi","family":"Samejima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison MM","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raza N","family":"Malik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shane JT","family":"Balthazaar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdullah","family":"Alrashidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rahul","family":"Sachdeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy L","family":"Elliott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas E","family":"Nightingale","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5782-2537","authenticated-orcid":false,"given":"Tania","family":"Lam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0022-7972","authenticated-orcid":false,"given":"Andrei V","family":"Krassioukov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,7,14]]},"reference":[{"key":"2023071408151364000_13.7.e070544.1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00942.2003"},{"key":"2023071408151364000_13.7.e070544.2","doi-asserted-by":"publisher","DOI":"10.1016\/j.resp.2009.08.003"},{"key":"2023071408151364000_13.7.e070544.3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.autneu.2017.09.015","article-title":"Autonomic Neuroscience: basic and clinical autonomic consequences of spinal cord injury","volume":"209","author":"Taylor","year":"2018","journal-title":"Auton Neurosci"},{"key":"2023071408151364000_13.7.e070544.4","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2015.3903"},{"key":"2023071408151364000_13.7.e070544.5","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2004.21.1371"},{"key":"2023071408151364000_13.7.e070544.6","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2011.2226"},{"key":"2023071408151364000_13.7.e070544.7","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a1aa68"},{"key":"2023071408151364000_13.7.e070544.8","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31824e8eaa"},{"key":"2023071408151364000_13.7.e070544.9","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000004224"},{"key":"2023071408151364000_13.7.e070544.10","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.apmr.2017.06.012","article-title":"Health conditions: effect on function, health-related quality of life, and life satisfaction after traumatic spinal cord injury. 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