{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T06:43:18Z","timestamp":1782801798504,"version":"3.54.5"},"reference-count":23,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T00:00:00Z","timestamp":1693785600000},"content-version":"unspecified","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Lena W\u00e4ppling foundation","award":["N\/A for the award\/grant number"],"award-info":[{"award-number":["N\/A for the award\/grant number"]}]},{"name":"Center for clinical research county of V\u00e4rmland","award":["LIVFOU-929703"],"award-info":[{"award-number":["LIVFOU-929703"]}]},{"name":"Swedish Cancer Society","award":["21 1408 Pj"],"award-info":[{"award-number":["21 1408 Pj"]}]},{"DOI":"10.13039\/501100004885","name":"Ume\u00e5 University","doi-asserted-by":"crossref","award":["N\/A for the award\/grant number"],"award-info":[{"award-number":["N\/A for the award\/grant number"]}],"id":[{"id":"10.13039\/501100004885","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement","award":["ALFGBG-965130 and ALF RegVB-969584"],"award-info":[{"award-number":["ALFGBG-965130 and ALF RegVB-969584"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec><jats:title>Introduction<\/jats:title><jats:p>Salpingectomy is currently suggested as an alternative to tubal ligation for sterilisation. Precursor lesions of ovarian carcinoma can be found in the fallopian tubes; thus, salpingectomy could possibly reduce the incidence. Most of the existing trials on safety are small, on caesarean section and report on surrogate ovarian function measures. Randomised trials in laparoscopy are lacking. Well-designed trials are needed to evaluate safety of laparoscopic opportunistic salpingectomy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and analysis<\/jats:title><jats:p>In SALSTER, a national register-based randomised controlled non-inferiority trial, 968\u2009women &lt;50 years, wishing laparoscopic sterilisation will be randomised to either salpingectomy or tubal ligation. The Swedish National Quality Register of Gynecological Surgery (GynOp) will be used for inclusion, randomisation and follow-up. Primary outcomes are<jats:italic>any complication<\/jats:italic>up to 8\u2009weeks postoperatively, and<jats:italic>age at menopause<\/jats:italic>. Both outcomes are measured with questionnaires, complications are also assessed by a gynaecologist. In a nested trial, ovarian function will be evaluated comparing the mean difference of anti-M\u00fcllerian hormone (AMH), assessed preoperatively and 1\u2009year after surgery.<\/jats:p><\/jats:sec><jats:sec><jats:title>Ethics and dissemination<\/jats:title><jats:p>Performing salpingectomy for sterilisation has become increasingly common, despite the unclear risk-benefit balance. SALSTER studies the safety of salpingectomy compared with tubal ligation. Regardless of the result, SALSTER will provide gynaecologists with high quality evidence to inform women to decide on salpingectomy or not. The central ethical review board of Gothenburg, Sweden (Dnr. 316\u201318) approved the trial in 2018. Results will be presented at scientific congresses and published in peer-reviewed scientific journals. The results will be communicated through professional organisations and research networks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Trial registration number<\/jats:title><jats:p><jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT03860805\">NCT03860805<\/jats:ext-link>.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2022-071246","type":"journal-article","created":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T16:50:14Z","timestamp":1693846214000},"page":"e071246","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["SALpingectomy for STERilisation (SALSTER): study protocol for a Swedish multicentre register-based randomised controlled trial"],"prefix":"10.1136","volume":"13","clinical-trial-number":[{"clinical-trial-number":"nct03860805","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9623-1302","authenticated-orcid":false,"given":"Leonidas","family":"Magarakis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Idahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Sundfeldt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Per","family":"Liv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathias","family":"P\u00e5lsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annika","family":"Strandell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,9,4]]},"reference":[{"key":"2024021507251147000_13.9.e071246.1","doi-asserted-by":"crossref","first-page":"x111","DOI":"10.1093\/annonc\/mds300","article-title":"New insights into ovarian cancer pathology","volume":"23 Suppl 10","author":"Prat","year":"2012","journal-title":"Ann Oncol"},{"key":"2024021507251147000_13.9.e071246.2","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/j.jogc.2016.12.005","article-title":"No.344-opportunistic Salpingectomy and other methods of risk reduction for ovarian\/Fallopian tube\/peritoneal cancer in the general population","volume":"39","author":"Salvador","year":"2017","journal-title":"J Obstet Gynaecol Can"},{"key":"2024021507251147000_13.9.e071246.3","doi-asserted-by":"crossref","first-page":"e279","DOI":"10.1097\/AOG.0000000000003164","article-title":"ACOG committee opinion No.774: opportunistic Salpingectomy as a strategy for epithelial ovarian cancer prevention","volume":"133","year":"2019","journal-title":"Obstet Gynecol"},{"key":"2024021507251147000_13.9.e071246.4","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.12516"},{"key":"2024021507251147000_13.9.e071246.5","doi-asserted-by":"publisher","DOI":"10.1002\/path.4934"},{"key":"2024021507251147000_13.9.e071246.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2014.10.005"},{"key":"2024021507251147000_13.9.e071246.7","doi-asserted-by":"crossref","unstructured":"Falconer H , Yin L , Gr\u00f6nberg H , et al . 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