{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T21:42:22Z","timestamp":1792100542676,"version":"4.4.0"},"reference-count":28,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T00:00:00Z","timestamp":1684368000000},"content-version":"unspecified","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Department for Foreign Affairs and Trade, Australian Government","award":["75889"],"award-info":[{"award-number":["75889"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,4,25]]},"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Historic disruption in health infrastructure combined with data from a recent vaccine coverage survey suggests there are likely significant immunity gaps to vaccine preventable diseases and high risk of outbreaks in Timor-Leste. Community-based serological surveillance is an important tool to augment understanding of population-level immunity achieved through vaccine coverage and\/or derived from prior infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This national population-representative serosurvey will take a three-stage cluster sample and aims to include 5600 individuals above 1\u2009year of age. Serum samples will be collected by phlebotomy and analysed for measles IgG, rubella IgG, SARS-CoV-2 antispike protein IgG, hepatitis B surface antibody and hepatitis B core antigen using commercially available chemiluminescent immunoassays or ELISA. In addition to crude prevalence estimates and to account for differences in Timor-Leste\u2019s age structure, stratified age-standardised prevalence estimates will be calculated, using Asia in 2013 as the standard population. Additionally, this survey will derive a national asset of serum and dried blood spot samples which can be used for further investigation of infectious disease seroepidemiology and\/or validation of existing and novel serological assays for infectious diseases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethical approval has been obtained from the Research Ethics and Technical Committee of the Instituto Nacional da Sa\u00fade, Timor-Leste and the Human Research Ethics Committee of the Northern Territory Department of Health and Menzies School of Health Research, Australia. Co-designing this study with Timor-Leste\u2019s Ministry-of-Health and other relevant partner organisations will allow immediate translation of findings into public health policy, which may include changes to routine immunisation service delivery and\/or plans for supplementary immunisation activities.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-071381","type":"journal-article","created":{"date-parts":[[2023,5,18]],"date-time":"2023-05-18T12:51:24Z","timestamp":1684414284000},"page":"e071381","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":3,"title":["Vaccine Preventable Disease Seroprevalence in a Nationwide Assessment of Timor-Leste (VASINA-TL): study protocol for a population-representative cross-sectional serosurvey"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3702-2716","authenticated-orcid":false,"given":"Paul","family":"Arkell","sequence":"first","affiliation":[{"name":"Global and Tropical Health Division, Menzies School of Health Research Timor-Leste Office, Dili, Timor-Leste"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah L","family":"Sheridan","sequence":"additional","affiliation":[{"name":"National Centre for Immunisation Research and Surveillance (NCIRS), Westmead, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson","family":"Martins","sequence":"additional","affiliation":[{"name":"Global and Tropical Health Division, Menzies School of Health Research Timor-Leste Office, Dili, Timor-Leste"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Y","family":"Tanesi","sequence":"additional","affiliation":[{"name":"Global and Tropical Health Division, Menzies School of Health Research Timor-Leste Office, Dili, Timor-Leste"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelia","family":"Gomes","sequence":"additional","affiliation":[{"name":"Global and Tropical Health Division, Menzies School of Health Research Timor-Leste Office, Dili, Timor-Leste"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salvador","family":"Amaral","sequence":"additional","affiliation":[{"name":"Global and Tropical Health Division, Menzies School of Health Research Timor-Leste Office, Dili, Timor-Leste"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tessa","family":"Oakley","sequence":"additional","affiliation":[{"name":"Global and Tropical Health Division, Menzies School of Health Research Timor-Leste Office, Dili, Timor-Leste"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanessa","family":"Solano","sequence":"additional","affiliation":[{"name":"Faculty of Science and Technology, Research 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