{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T23:27:28Z","timestamp":1765841248458,"version":"3.48.0"},"reference-count":26,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T00:00:00Z","timestamp":1691452800000},"content-version":"unspecified","delay-in-days":7,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"NIHR BRC Exeter","award":["BRC"],"award-info":[{"award-number":["BRC"]}]},{"DOI":"10.13039\/501100000272","name":"NIHR","doi-asserted-by":"crossref","award":["COV-LT2-0016"],"award-info":[{"award-number":["COV-LT2-0016"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000272","name":"NIHR","doi-asserted-by":"crossref","award":["ISRCTN15022307"],"award-info":[{"award-number":["ISRCTN15022307"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100000272","name":"NIHR","doi-asserted-by":"crossref","award":["NCT05057260"],"award-info":[{"award-number":["NCT05057260"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,6,28]]},"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>A substantial proportion of COVID-19 survivors continue to have symptoms more than 3\u2009months after infection, especially of those who required medical intervention. Lasting symptoms are wide-ranging, and presentation varies between individuals and fluctuates within an individual. Improved understanding of undulation in symptoms and triggers may improve efficacy of healthcare providers and enable individuals to better self-manage their Long Covid. We present a protocol where we aim to develop and examine the feasibility and usability of digital home monitoring for capturing daily fluctuation of symptoms in individuals with Long Covid and provide data to facilitate a personalised approach to the classification and management of Long Covid symptoms.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This study is a longitudinal prospective cohort study of adults with Long Covid accessing 10 National Health Service (NHS) rehabilitation services in the UK. We aim to recruit 400 people from participating NHS sites. At referral to study, 6\u2009weeks and 12 weeks, participants will complete demographic data (referral to study) and clinical outcome measures, including ecological momentary assessment (EMA) using personal mobile devices. EMA items are adapted from the COVID-19 Yorkshire Rehabilitation Scale items and include self-reported activities, symptoms and psychological factors. Passive activity data will be collected through wrist-worn sensors. We will use latent class growth models to identify trajectories of experience, potential phenotypes defined by co-occurrence of symptoms and inter-relationships between stressors, symptoms and participation in daily activities. We anticipate that n=300 participants provide 80% power to detect a 20% improvement in fatigue over 12 weeks in one class of patients relative to another.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The study was approved by the Yorkshire &amp; The Humber\u2014Bradford Leeds Research Ethics Committee (ref: 21\/YH\/0276). Findings will be disseminated in peer-reviewed publications and presented at conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"isrctn\" xlink:href=\"ISRCTN15022307\">ISRCTN15022307<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-071428","type":"journal-article","created":{"date-parts":[[2023,8,8]],"date-time":"2023-08-08T11:17:35Z","timestamp":1691493455000},"page":"e071428","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Digital home monitoring for capturing daily fluctuation of symptoms; a longitudinal repeated measures study: Long Covid Multi-disciplinary Consortium to Optimise Treatments and Services across the NHS (a LOCOMOTION study)"],"prefix":"10.1136","volume":"13","clinical-trial-number":[{"clinical-trial-number":"isrctn15022307","registry":"10.18810\/isrctn"},{"clinical-trial-number":"isrctn15022307","registry":"10.18810\/isrctn"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8829-2217","authenticated-orcid":false,"given":"Maedeh","family":"Mansoubi","sequence":"first","affiliation":[{"name":"NIHR Exeter Biomedical Research Center, Medical School, Faculty of Health and Life sciences, University of Exeter, Exeter, UK"},{"name":"Medical School, University of Exeter, Exeter, UK"},{"name":"Department of Public Health and Sport Sciences, University of Exeter, Exeter, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Dawes","sequence":"additional","affiliation":[{"name":"Medical School, University of Exeter, Exeter, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aishwarya","family":"Bhatia","sequence":"additional","affiliation":[{"name":"Medical School, University of Exeter, Exeter, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Himanshu","family":"Vashisht","sequence":"additional","affiliation":[{"name":"In The Wild Research Limited, Dublin, Ireland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johnny","family":"Collett","sequence":"additional","affiliation":[{"name":"Department of Sport, Health and Social Work, Oxford Brookes University, Oxford, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7035-3096","authenticated-orcid":false,"given":"Darren C","family":"Greenwood","sequence":"additional","affiliation":[{"name":"Academic Department of Rehabilitation Medicine, University of Leeds, Leeds, 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