{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T18:31:31Z","timestamp":1790188291048,"version":"4.1.0"},"reference-count":22,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T00:00:00Z","timestamp":1685491200000},"content-version":"unspecified","delay-in-days":30,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Science and Technology Project of Gansu Province","award":["20JR10RA435"],"award-info":[{"award-number":["20JR10RA435"]}]},{"name":"Science and Technology Project of Gansu Province","award":["20YF3FA020"],"award-info":[{"award-number":["20YF3FA020"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81760892"],"award-info":[{"award-number":["81760892"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260973"],"award-info":[{"award-number":["82260973"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,5,17]]},"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Painless gastrointestinal endoscopy is being increasingly practised in the clinical field. The management and choice of sedation are important during the endoscopy procedure to reduce patient discomfort and facilitate high disease detection rates. Ciprofol is principally an agonist of the \u03b3-aminobutyric acid type A receptor; it comprises the active ingredient HSK3486, which is similar to the currently used intravenous anaesthetic propofol in clinical practice. A systematic review and meta-analysis comparing ciprofol and propofol will be conducted to assess their efficacy and safety during endoscopy. Before starting the study, we describe the specific protocol of this systematic review.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>This protocol was prepared in accordance with the Preferred Reporting Items for Systematic Review and Meta-analysis Protocols 2015. The following databases will be searched: Embase, Cochrane Library, PubMed, Web of Science, Chinese Biomedical Literature Service System, China National Knowledge Infrastructure, Wanfang Database, China Science and Technology Journal Database and a clinical trial registry. The database search strategy will adopt a combination of subject words and free words. Randomised controlled trials related to ciprofol use for sedation during gastrointestinal endoscopy will also be included. Based on the inclusion and exclusion criteria, two researchers will independently screen the articles and extracted data. Following the qualitative evaluation of each study, analysis will be conducted using Review Manager software.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Ethics and dissemination<\/jats:title>\n                  <jats:p>The protocol for this systematic review and meta-analysis involves no individual patient data; thus, ethical approval is not required. This will be the first meta-analysis to assess the sedation efficacy of ciprofol and provide evidence to clinicians for decision-making. The results will be disseminated through conference presentations and publications in peer-review journals related to this field.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>PROSPERO registration number<\/jats:title>\n                  <jats:p>CRD42022370047.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2022-071438","type":"journal-article","created":{"date-parts":[[2023,5,31]],"date-time":"2023-05-31T11:30:43Z","timestamp":1685532643000},"page":"e071438","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Ciprofol versus propofol for sedation in gastrointestinal endoscopy: protocol for a systematic review and meta-analysis"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5259-2229","authenticated-orcid":false,"given":"Xiaoyu","family":"Qin","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Shanghai East Hospital, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoting","family":"Lu","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Tang","sequence":"additional","affiliation":[{"name":"The First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou, China"},{"name":"Anesthesia and Pain Medical Center, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunai","family":"Wang","sequence":"additional","affiliation":[{"name":"Anesthesia and Pain Medical Center, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjun","family":"Xue","sequence":"additional","affiliation":[{"name":"Anesthesia and Pain Medical Center, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,5,31]]},"reference":[{"key":"2025101810522481000_13.5.e071438.1","doi-asserted-by":"crossref","first-page":"456","DOI":"10.5217\/ir.2017.15.4.456","article-title":"Sedation for routine gastrointestinal endoscopic procedures: a review on efficacy, safety, efficiency, cost and satisfaction","volume":"15","author":"Lin","year":"2017","journal-title":"Intest Res"},{"key":"2025101810522481000_13.5.e071438.2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2007.01778.x"},{"key":"2025101810522481000_13.5.e071438.3","doi-asserted-by":"crossref","DOI":"10.3390\/diagnostics12071523","article-title":"Efficacy and safety of deep sedation and anaesthesia for complex endoscopic procedures-A","volume":"12","author":"Godoroja-Diarto","year":"2022","journal-title":"Diagnostics (Basel)"},{"key":"2025101810522481000_13.5.e071438.4","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1016\/S0016-5107(99)70308-1","article-title":"Propofol in the Endoscopy suite: an Anesthesiologist\u2019s perspective","volume":"49","author":"Graber","year":"1999","journal-title":"Gastrointest Endosc"},{"key":"2025101810522481000_13.5.e071438.5","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1097\/SGA.0b013e3181eac371","article-title":"Review of propofol and auxiliary medications used for sedation","volume":"33","author":"Ellett","year":"2010","journal-title":"Gastroenterol Nurs"},{"key":"2025101810522481000_13.5.e071438.6","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1213\/00000539-199105000-00002","article-title":"Rate-dependent induction phenomena with propofol: implications for the relative potency of intravenous anesthetics","volume":"72","author":"Stokes","year":"1991","journal-title":"Anesth Analg"},{"key":"2025101810522481000_13.5.e071438.7","doi-asserted-by":"crossref","first-page":"3606","DOI":"10.1021\/acs.jmedchem.7b00254","article-title":"Design, synthesis, and evaluation of novel 2,6-Disubstituted phenol derivatives as general anesthetics","volume":"60","author":"Qin","year":"2017","journal-title":"J Med Chem"},{"key":"2025101810522481000_13.5.e071438.8","doi-asserted-by":"crossref","first-page":"397","DOI":"10.31480\/2330-4871\/147","article-title":"Ciprofol: A novel medication from development towards clinical use","volume":"8","author":"Tingting","year":"2021","journal-title":"Transl Perioper & Pain Med"},{"key":"2025101810522481000_13.5.e071438.9","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.830791","article-title":"Pharmacodynamics and pharmacokinetics of Hsk3486, a novel 2,6-Disubstituted phenol derivative as a general anesthetic","volume":"13","author":"Liao","year":"2022","journal-title":"Front Pharmacol"},{"key":"2025101810522481000_13.5.e071438.10","doi-asserted-by":"crossref","first-page":"5484","DOI":"10.1007\/s12325-021-01914-4","article-title":"Sedation effects produced by a Ciprofol initial infusion or bolus dose followed by continuous maintenance infusion in healthy subjects: A phase 1 trial","volume":"38","author":"Hu","year":"2021","journal-title":"Adv Ther"},{"key":"2025101810522481000_13.5.e071438.11","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/9541060","article-title":"Comparison and clinical value of Ciprofol and propofol in intraoperative adverse reactions, operation, resuscitation, and satisfaction of patients under painless Gastroenteroscopy anesthesia","volume":"2022","author":"Chen","year":"2022","journal-title":"Contrast Media Mol Imaging"},{"key":"2025101810522481000_13.5.e071438.12","first-page":"712","article-title":"Comparison of Ciprofol and propofol in elderly patients undergoing Gastroscopy","volume":"38","author":"Yi","year":"2022","journal-title":"J Clin Anesthesiol"},{"key":"2025101810522481000_13.5.e071438.13","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/bcpt.13761","article-title":"Comparison of Ciprofol (Hsk3486) versus propofol for the induction of deep sedation during Gastroscopy and colonoscopy procedures: A multi-centre, non-inferiority, randomized, controlled phase 3 clinical trial","volume":"131","author":"Li","year":"2022","journal-title":"Basic Clin Pharmacol Toxicol"},{"key":"2025101810522481000_13.5.e071438.14","first-page":"35","article-title":"Application of Ciprofol in anesthesia of painless gastrointestinal Endoscopy","volume":"16","author":"Zhang","year":"2022","journal-title":"Chin J Mod Drug Appl"},{"key":"2025101810522481000_13.5.e071438.15","unstructured":"Higgins JPT , Thomas J , Chandler J , et al . Cochrane Handbook for systematic reviews of interventions version 6.3 (updated February 2022). 2022. Available: www.training.cochrane.org\/handbook"},{"key":"2025101810522481000_13.5.e071438.16","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.g7647","article-title":"Preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015: elaboration and explanation","volume":"350","author":"Shamseer","year":"2015","journal-title":"BMJ"},{"key":"2025101810522481000_13.5.e071438.17","doi-asserted-by":"crossref","first-page":"2520","DOI":"10.1177\/0962280219889080","article-title":"Estimating the sample mean and standard deviation from commonly reported Quantiles in meta-analysis","volume":"29","author":"McGrath","year":"2020","journal-title":"Stat Methods Med Res"},{"key":"2025101810522481000_13.5.e071438.18","doi-asserted-by":"publisher","DOI":"10.1177\/0962280216669183"},{"key":"2025101810522481000_13.5.e071438.19","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2288-14-135","article-title":"Estimating the sample mean and standard deviation from the sample size, median, range and\/or Interquartile range","volume":"14","author":"Wan","year":"2014","journal-title":"BMC Med Res Methodol"},{"key":"2025101810522481000_13.5.e071438.20","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejps.2021.105904","article-title":"Efficacy and safety of Ciprofol for the sedation\/anesthesia in patients undergoing colonoscopy: phase IIa and IIb multi-center clinical trials","volume":"164","author":"Teng","year":"2021","journal-title":"Eur J Pharm Sci"},{"key":"2025101810522481000_13.5.e071438.21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0264197","article-title":"Effectiveness of Acupuncture therapy for preventing emergence agitation in children: A protocol for systematic review and meta-analysis with trial sequential analysis","volume":"17","author":"Nakajima","year":"2022","journal-title":"PLoS One"},{"key":"2025101810522481000_13.5.e071438.22","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1177\/2050640616688140","article-title":"Dexmedetomidine vs propofol for gastrointestinal Endoscopy: A meta-analysis","volume":"5","author":"Nishizawa","year":"2017","journal-title":"United European Gastroenterol J"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2022-071438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T17:52:38Z","timestamp":1760809958000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2022-071438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5]]},"references-count":22,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2023,5,31]]},"published-print":{"date-parts":[[2023,5]]}},"alternative-id":["10.1136\/bmjopen-2022-071438"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2022-071438","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5]]}}}