{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:21:22Z","timestamp":1780082482163,"version":"3.54.0"},"reference-count":31,"publisher":"BMJ","issue":"5","license":[{"start":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T00:00:00Z","timestamp":1683158400000},"content-version":"unspecified","delay-in-days":3,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Clinical Incubation Program of the National Medical Center of LongHua Hospital","award":["GY202201"],"award-info":[{"award-number":["GY202201"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,4,19]]},"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Insomnia has a high incidence in patients with breast cancer, which not only affects the quality of life of patients, but also affects the efficiency of later treatment and rehabilitation. Although the sedative and hypnotic drugs commonly used in clinical practice have a rapid onset of action, they are also accompanied by different degrees of sequelae, withdrawal effects and dependence and addiction. Complementary and alternative medicine (CAM) or complementary and integrative medicine, complementary integrative therapies, including natural nutritional supplement therapy, psychotherapy, physical and mental exercise, physiotherapy, have been reported to be used to treat cancer-related insomnia. Its clinical results are increasingly recognised and accepted by patients. However, the effectiveness and safety of these CAM are uneven, and there is no standard clinical application method. Therefore, in order to objectively evaluate the effects of different non-pharmaceutical interventions in CAM on insomnia, we will conduct a network meta-analysis (NMA) to explore the effects of different CAM interventions on improving sleep quality in patients with breast cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>We will search all Chinese and English databases from the inception of the database to 31 December 2022. The databases include PubMed, Medline, Embase, Web of Science and Cochrane Central Register of Controlled Trials and the Chinese literature databases include CBM, CNKI, VIP, WANFANG. The Insomnia Severity Index and the Pittsburgh Sleep Quality Index will be considered as the primary outcomes in the study. STATA V.15.0 software will be used to conduct pairwise meta-analysis and NMA. Finally, we will use the recommended risk assessment tool RoB2 for risk and bias assessment, and use the Grading of Recommendations Assessment, Development and Evaluation evaluation method to evaluate the quality of evidence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethical approval will not be required because the study will not include the original information of participants. The results will be published in a peer-reviewed journal or disseminated in relevant conferences.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD42022382602.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-071784","type":"journal-article","created":{"date-parts":[[2023,5,4]],"date-time":"2023-05-04T11:10:13Z","timestamp":1683198613000},"page":"e071784","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Non-pharmaceutical interventions in complementary and alternative medicine for insomnia in breast cancer survivors: a protocol for a systematic review and network meta-analysis"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7915-3007","authenticated-orcid":false,"given":"Qi","family":"Jin","sequence":"first","affiliation":[{"name":"Sleep Medicine Center, LongHua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China"},{"name":"Acupuncture Department, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5981-2666","authenticated-orcid":false,"given":"Lumin","family":"Liu","sequence":"additional","affiliation":[{"name":"Sleep Medicine Center, LongHua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuelai","family":"Chen","sequence":"additional","affiliation":[{"name":"Sleep Medicine Center, LongHua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6379-4966","authenticated-orcid":false,"given":"Ping","family":"Yin","sequence":"additional","affiliation":[{"name":"Sleep Medicine Center, LongHua Hospital Shanghai University of Traditional Chinese Medicine, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,5,4]]},"reference":[{"key":"2025121411445632000_13.5.e071784.1","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.sleep.2019.02.018","article-title":"The course of cancer-related insomnia: don't expect it to disappear after cancer treatment","volume":"58","author":"Schieber","year":"2019","journal-title":"Sleep Med"},{"key":"2025121411445632000_13.5.e071784.2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.33.2247"},{"key":"2025121411445632000_13.5.e071784.3","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.1007\/s11136-018-1866-8","article-title":"Quality of life, problems, and needs of disease-free breast cancer survivors 5 years after diagnosis","volume":"27","author":"Schmidt","year":"2018","journal-title":"Qual Life Res"},{"key":"2025121411445632000_13.5.e071784.4","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.sleep.2016.06.041","article-title":"Sleep duration is associated with survival in advanced cancer patients","volume":"32","author":"Collins","year":"2017","journal-title":"Sleep Med"},{"key":"2025121411445632000_13.5.e071784.5","first-page":"2417","article-title":"Sleep disturbance in cancer patients referred to an ambulatory integrative oncology consultation","volume":"30","author":"Narayanan","year":"2022","journal-title":"Support Care Cancer"},{"key":"2025121411445632000_13.5.e071784.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.breast.2014.09.003"},{"key":"2025121411445632000_13.5.e071784.7","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29244"},{"key":"2025121411445632000_13.5.e071784.8","unstructured":"National Center for Complementary and Integrative Health (NCCIH) . Complementary, alternative, or integrative health: what\u2019s in a name? secondary national center for complementary and integrative health (NCCIH) (2016) complementary, alternative, or integrative health: what\u2019s in a name? 2016. Available: https:\/\/nccih.nih.gov\/health\/integrative-health#integrative"},{"key":"2025121411445632000_13.5.e071784.9","unstructured":"Smith JA . 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