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Similarly low coverage was revealed for Semantic Medline (SemMedDB) semantic triples derived from MR and RCT publications \u201336% and 12%, respectively. Among intervention types that can be mimicked by MR, only trials of pharmaceutical interventions could be automatically matched to MR results due to insufficient annotation with Medical Subject Headings ontology. A manual survey of the literature highlighted the potential for triangulation across a number of exposure\/outcome pairs if these challenges can be addressed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We conclude that careful triangulation of MR with RCT evidence should involve consideration of similarity of phenotypes across study designs, intervention intensity and duration, study population demography and health status, comparator group, intervention goal and quality of evidence.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2023-072087","type":"journal-article","created":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T17:11:35Z","timestamp":1695748295000},"page":"e072087","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Systematic comparison of Mendelian randomisation studies and randomised controlled trials using electronic databases"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0000-4100","authenticated-orcid":false,"given":"Maria K","family":"Sobczyk","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6623-6839","authenticated-orcid":false,"given":"Jie","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1407-8314","authenticated-orcid":false,"given":"George","family":"Davey Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0924-3247","authenticated-orcid":false,"given":"Tom R","family":"Gaunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,9,26]]},"reference":[{"key":"2023100106304341000_13.9.e072087.1","doi-asserted-by":"crossref","unstructured":"Ference BA , Holmes MV , Smith GD . 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