{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T10:54:04Z","timestamp":1793357644074,"version":"4.5.0"},"reference-count":76,"publisher":"BMJ","issue":"7","license":[{"start":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T00:00:00Z","timestamp":1689552000000},"content-version":"unspecified","delay-in-days":16,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Health Education England and the National Institute for Health and Care Research","award":["NIHR302680"],"award-info":[{"award-number":["NIHR302680"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,7,3]]},"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>There is significant potential to improve outcomes for patients with lung cancer in terms of quality of life and survival. There is some evidence that prehabilitation can help, but, to date, this has only been tested in surgical populations, despite 70%\u201380% of patients with lung cancer in the UK receiving non-surgical treatment. The physiological and psychological benefits of prehabilitation seen in surgical patients could be extrapolated to those receiving non-surgical treatment, particularly in such a poor prognosis group. With patients and healthcare professionals, we have co-designed a personalised and evidence-based prehabilitation programme. This draws on a conceptual framework that aligns with patient values and needs as well as functional goals. We aim to investigate whether this programme is feasible to implement and evaluate in clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>An open-label, single-group feasibility study incorporating quantitative assessments, a qualitative free text questionnaire and reflective field notes. Thirty participants will be recruited over an eight-month period from a single London teaching hospital. All recruited participants will receive a personalised prehabilitation programme during their oncological treatment. This includes a one-hour face-to-face appointment prior to, at week three and at week six of their treatment regimen as well as a weekly telephone call. Interventions including nutrition, physical activity and psychological well-being are stratified according to a patient\u2019s priorities, level of readiness and expressed needs. The primary outcome will be feasibility of the personalised prehabilitation programme in clinical practice by investigating areas of uncertainty regarding patient recruitment, attrition, treatment fidelity, intervention adherence and acceptability of study outcome measures. Secondary outcomes will include quality of life, functional capacity and grip strength.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>Ethical approval has been obtained from the Health Research Authority (reference number 22\/PR\/0390). Results of this study will be disseminated through publication in peer-reviewed articles, presentations at scientific conferences and in collaboration with patient and public involvement representatives.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT05318807\">NCT05318807<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-072367","type":"journal-article","created":{"date-parts":[[2023,7,17]],"date-time":"2023-07-17T21:15:50Z","timestamp":1689628550000},"page":"e072367","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Is personalised prehabilitation feasible to implement for patients undergoing oncological treatment for lung cancer at a London teaching hospital? Protocol of a feasibility trial"],"prefix":"10.1136","volume":"13","clinical-trial-number":[{"clinical-trial-number":"nct05318807","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct05318807","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6509-0359","authenticated-orcid":false,"given":"Kelly","family":"Wade-Mcbane","sequence":"first","affiliation":[{"name":"Department of Nutrition and Dietetics, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9050-1092","authenticated-orcid":false,"given":"Alex","family":"King","sequence":"additional","affiliation":[{"name":"Department of Surgery, Cardiovascular and Cancer, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4251-9113","authenticated-orcid":false,"given":"Catherine","family":"Urch","sequence":"additional","affiliation":[{"name":"Department of Surgery, Cardiovascular and Cancer, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8571-0567","authenticated-orcid":false,"given":"Lina","family":"Johansson","sequence":"additional","affiliation":[{"name":"Department of Nutrition and Dietetics, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5789-2773","authenticated-orcid":false,"given":"Mary","family":"Wells","sequence":"additional","affiliation":[{"name":"Department of Surgery and Oncology, Nursing Directorate, Imperial College Healthcare NHS Trust, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,7,17]]},"reference":[{"key":"2025121511175574000_13.7.e072367.1","doi-asserted-by":"crossref","DOI":"10.1186\/s12876-018-0754-6","article-title":"The effects of Prehabilitation versus usual care to reduce postoperative complications in high-risk patients with colorectal cancer or dysplasia scheduled for elective colorectal resection: study protocol of a randomized controlled trial","volume":"18","author":"Berkel","year":"2018","journal-title":"BMC Gastroenterol"},{"key":"2025121511175574000_13.7.e072367.2","doi-asserted-by":"crossref","DOI":"10.1186\/s12885-018-5232-6","article-title":"Multimodal Prehabilitation in colorectal cancer patients to improve functional capacity and reduce postoperative complications: the first International randomized controlled trial for Multimodal Prehabilitation","volume":"19","author":"van Rooijen","year":"2019","journal-title":"BMC Cancer"},{"key":"2025121511175574000_13.7.e072367.3","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.ejso.2020.04.042","article-title":"Implementing a system-wide cancer Prehabilitation programme: the journey of greater Manchester's 'Prehab4Cancer'","volume":"47","author":"Moore","year":"2021","journal-title":"Eur J Surg Oncol"},{"key":"2025121511175574000_13.7.e072367.4","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-050806","article-title":"Pre-admission interventions (Prehabilitation) to improve outcome after major elective surgery: a systematic review and meta-analysis","volume":"11","author":"Perry","year":"2021","journal-title":"BMJ Open"},{"key":"2025121511175574000_13.7.e072367.5","doi-asserted-by":"crossref","unstructured":"Cochrane Colorectal Group, Molenaar CJ , van Rooijen SJ , et al . 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