{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T17:07:52Z","timestamp":1789319272948,"version":"build-2803163510"},"reference-count":24,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"unspecified","delay-in-days":25,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Fogarty International Center of the National Institutes of Health","award":["1K43TW010683"],"award-info":[{"award-number":["1K43TW010683"]}]},{"DOI":"10.13039\/501100007936","name":"International AIDS Society","doi-asserted-by":"publisher","award":["2020\/400-DUB"],"award-info":[{"award-number":["2020\/400-DUB"]}],"id":[{"id":"10.13039\/501100007936","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,6,16]]},"published-print":{"date-parts":[[2023,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>The global antiretroviral therapy era has led to a decline in the number of children newly acquiring HIV and an increase in the number of children who are HIV-exposed and uninfected (HEU). This shift has prompted extensive research focussing on health and survival outcomes of children who are HEU. Study findings, particularly in relation to adverse birth outcomes, have been disparate, inconclusive and have not always been generalisable. Thus, the objectives of this scoping review are (1) to identify and extract definitions used for the adverse birth outcome terms \u2018low birth weight\u2019, \u2018small for gestational age\u2019, \u2018stillbirth\u2019 and \u2018preterm birth\u2019; (2) to compare the characteristics of studies from which birth outcome definitions were extracted by (a) temporal periods and (b) study country setting (high-income vs low-income and middle-income countries); (3) to use content analysis to map and describe the temporal and geographic distribution of the definitions used and construct a logical model of their evolution.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>The online databases of PubMed\/MEDLINE, Scopus, Web of Science, Cochrane Library and CINHAL\/EBSCOhost will be used to identify published and grey literature from 2011 to 2022 to identify definitions for the adverse birth outcome terms \u2018low birth weight\u2019, \u2018small for gestational age\u2019, \u2018stillbirth\u2019 and \u2018preterm birth\u2019. A three-step process of (1) duplicate removal, (2) title and abstract screening and (3) full text screening will be used to select included studies. The extracted data will be used to conduct a comparative analysis, content analysis and construct a logic model.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This review will be used to inform a consensus process around the development of harmonised definitions for the specified adverse birth outcomes. Our dissemination plan includes presentations, publications as well as the development infographics and a resource hub. The study is approved by the Human Research Ethics Committee of Stellenbosch University.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-072417","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T23:56:41Z","timestamp":1687823801000},"page":"e072417","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Adverse birth outcome case definitions associated with maternal HIV and antiretroviral drug use in pregnancy: a scoping review protocol"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6609-3516","authenticated-orcid":false,"given":"Kopano Rebaona","family":"Dube","sequence":"first","affiliation":[{"name":"Deparmtment of Paediatrics & Child Health, Stellenbosch University Faculty of Medicine and Health Sciences, Cape Town, Western Cape, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen M","family":"Powis","sequence":"additional","affiliation":[{"name":"Deparment of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA"},{"name":"Departments of Internal Medicine and Paediatrics, Massachusetts General Hospital, Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"McCaul","sequence":"additional","affiliation":[{"name":"Division of Epidemiology and Biostatistics, Department of Global Health, Stellenbosch University Faculty of Medicine and Health Sciences, Cape Town, Western Cape, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shani Tamlyn","family":"de Beer","sequence":"additional","affiliation":[{"name":"Centre for Infectious Disease Epidemiology and Research, Faculty of Health Sciences University of Cape Town, Cape Town, Western Cape, South Africa"},{"name":"Population Health Sciences, University of Bristol, Bristol, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8046-9268","authenticated-orcid":false,"given":"Amy L","family":"Slogrove","sequence":"additional","affiliation":[{"name":"Deparmtment of Paediatrics & Child Health, Stellenbosch University Faculty of Medicine and Health Sciences, Cape Town, Western Cape, South Africa"},{"name":"Ukwanda Centre for Rural Health, Department of Global Health, Stellenbosch University, Stellenbosch, South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,6,26]]},"reference":[{"key":"2025120519400398000_13.6.e072417.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(16)00055-4"},{"key":"2025120519400398000_13.6.e072417.2","unstructured":"UNAIDS . 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