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Early differentiation of AD from mild cognitive impairment (MCI) is necessary.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 458 patients newly diagnosed with AD and MCI were included. Eleven batteries were used to evaluate ADL, BPSD and cognitive function (ABC). Machine learning approaches including XGboost, classification and regression tree, Bayes, support vector machines and logical regression were used to build and verify the new tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The Alzheimer\u2019s Disease Assessment Scale (ADAS-cog) word recognition task showed the best importance in judging AD and MCI, followed by correct numbers of auditory verbal learning test delay recall and ADAS-cog orientation. We also provided a selected ABC-Scale that covered ADL, BPSD and cognitive function with an estimated completion time of 18\u2009min. The sensitivity was improved in the four models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The quick screen ABC-Scale covers three dimensions of ADL, BPSD and cognitive function with good efficiency in differentiating AD from MCI.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2023-073011","type":"journal-article","created":{"date-parts":[[2023,12,9]],"date-time":"2023-12-09T18:21:58Z","timestamp":1702146118000},"page":"e073011","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Differentiating Alzheimer\u2019s disease from mild cognitive impairment: a quick screening tool based on machine learning"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4083-8257","authenticated-orcid":false,"given":"Wenqi","family":"L\u00fc","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6004-9138","authenticated-orcid":false,"given":"Meiwei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihua","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weihong","family":"Kuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihua","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7071-5931","authenticated-orcid":false,"given":"Wenbo","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"L\u00fc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,12,9]]},"reference":[{"key":"2023121221223944000_13.12.e073011.1"},{"key":"2023121221223944000_13.12.e073011.2","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3233\/JAD-180375","article-title":"Secular trends in dementia prevalence and incidence worldwide: A systematic review","volume":"66","author":"Stephan","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"2023121221223944000_13.12.e073011.3","doi-asserted-by":"crossref","unstructured":"Hodson R . 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