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This infection is associated with high rates of mortality and morbidity related, among other factors, to the excessive host response to the pneumococcal lysis. Experimental in vitro and in vivo data show that the combination of corticosteroids\/third-generation cephalosporins and the non-lytic antibiotic, daptomycin, has synergistic effects with (1) a rapid cerebrospinal fluid sterilisation, (2) less brain damages and (3) less loss of cognitive performances. Despite these encouraging results, daptomycin has never been evaluated in adult patients with pneumococcal meningitis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>The AddaMAP trial is a phase II, open-label, Simon\u2019s two-stage, multicentre trial that has been designed to assess the efficacy and safety of adding daptomycin (10 mg\/kg\/d for 8 days) to the recommended treatment (corticosteroids+third generation cephalosporin) in adults with confirmed pneumococcal meningitis. The main endpoint is the disability-free survival (defined as modified Rankin Scale mRS\u22642) at day 30. Secondary outcomes are overall mortality, disability at D30 and D90 (mRS, Glasgow Coma Scale and Glasgow Outcome Scales, mini-mental score), hearing loss (Hearing Handicap Inventory Test at D30 and D90, routine audiometric test and Hearing-it test at D30), and quality of life (12-item Short Form Survey and WHO QOL BREF). Seventy-two analysable patients are required.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The study protocol was approved by the Institutional Review Board of the IDF 1 of the ethics committee on 16 January 2018, and authorisation was obtained from the Agence Nationale de Securit\u00e9 des M\u00e9dicaments et des Produits de Sant\u00e9 on 22 September 2017. The results will be submitted for publication in a peer-reviewed journal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT03480191\">NCT03480191<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-073032","type":"journal-article","created":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T13:09:51Z","timestamp":1690290591000},"page":"e073032","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Addition of daptomycin for the treatment of pneumococcal meningitis: protocol for the AddaMAP study"],"prefix":"10.1136","volume":"13","clinical-trial-number":[{"clinical-trial-number":"nct03480191","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7263-792X","authenticated-orcid":false,"given":"Pascal","family":"Chavanet","sequence":"first","affiliation":[{"name":"Infectious Diseases Department, University Hospital, Dijon, France"},{"name":"INSERM, CIC 1432, Module Epid\u00e9miologie Clinique, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Fournel","sequence":"additional","affiliation":[{"name":"INSERM, CIC 1432, Module Epid\u00e9miologie Clinique, Dijon, France"},{"name":"Centre d'Investigation Clinique, CHU Dijon, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abderrahmane","family":"Bourredjem","sequence":"additional","affiliation":[{"name":"INSERM, CIC 1432, Module Epid\u00e9miologie Clinique, Dijon, France"},{"name":"Centre d'Investigation Clinique, CHU Dijon, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4478-1032","authenticated-orcid":false,"given":"Lionel","family":"Piroth","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, University Hospital, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Blot","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, University Hospital, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thibault","family":"Sixt","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department, University Hospital, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9417-5754","authenticated-orcid":false,"given":"Christine","family":"Binquet","sequence":"additional","affiliation":[{"name":"INSERM, CIC 1432, Module Epid\u00e9miologie Clinique, Dijon, France"},{"name":"Centre d'Investigation Clinique, CHU Dijon, Dijon, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,7,25]]},"reference":[{"key":"2025121409195030000_13.7.e073032.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(15)00430-2"},{"key":"2025121409195030000_13.7.e073032.2","doi-asserted-by":"crossref","first-page":"1192","DOI":"10.1016\/j.cmi.2019.12.020","article-title":"Community-acquired bacterial meningitis in adults: in-hospital prognosis, long-term disability and determinants of outcome in a multicentre prospective cohort","volume":"26","author":"Tubiana","year":"2020","journal-title":"Clin Microbiol Infect"},{"key":"2025121409195030000_13.7.e073032.3","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.cmi.2016.10.026","article-title":"Sex-based differences in adults with community-acquired bacterial meningitis: a prospective cohort study","volume":"23","author":"Dias","year":"2017","journal-title":"Clin Microbiol Infect"},{"key":"2025121409195030000_13.7.e073032.4","doi-asserted-by":"publisher","DOI":"10.1542\/peds.102.5.1087"},{"key":"2025121409195030000_13.7.e073032.5","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199301073280104"},{"key":"2025121409195030000_13.7.e073032.6","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2013.09.012"},{"key":"2025121409195030000_13.7.e073032.7","unstructured":"Le r\u00e9seau Epibac . 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