{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T02:38:43Z","timestamp":1784774323015,"version":"3.55.0"},"reference-count":30,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T00:00:00Z","timestamp":1694736000000},"content-version":"unspecified","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Danish Research Foundation","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}]},{"DOI":"10.13039\/501100009753","name":"Region J\u00f6nk\u00f6pings l\u00e4ns","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/501100009753","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2004\u22121881"],"award-info":[{"award-number":["2004\u22121881"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012774","name":"Innovationsfonden","doi-asserted-by":"publisher","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100012774","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016670","name":"Region \u00d6sterg\u00f6tland","doi-asserted-by":"publisher","award":["LIO 131471"],"award-info":[{"award-number":["LIO 131471"]}],"id":[{"id":"10.13039\/100016670","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016670","name":"Region \u00d6sterg\u00f6tland","doi-asserted-by":"publisher","award":["R\u00d6-910951"],"award-info":[{"award-number":["R\u00d6-910951"]}],"id":[{"id":"10.13039\/100016670","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003793","name":"Hj\u00e4rt-Lungfonden","doi-asserted-by":"publisher","award":["2004053"],"award-info":[{"award-number":["2004053"]}],"id":[{"id":"10.13039\/501100003793","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,9,1]]},"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>To investigate the association between type I collagen \u03b11 chain (COL1\u03b11) levels and coronary artery disease (CAD) by using absolute quantification in plasma. Also, to investigate the correlates of COL1\u03b11 to clinical characteristics and circulating markers of collagen metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Life conditions, Stress and Health (LSH) study: prospective cohort study, here with a nested case\u2013control design.<\/jats:p>\n                    <jats:p>Assessing Platelet Activity in Coronary Heart Disease (APACHE) study: prospective cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>LSH: primary care setting, southeast Sweden.<\/jats:p>\n                    <jats:p>APACHE: cardiology department, university hospital, southeast Sweden.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>LSH: 1007 randomly recruited individuals aged 45\u201369 (50% women). Exclusion criteria was serious disease. After 13 years of follow-up, 86 cases with primary endpoint were identified and sex-matched\/age-matched to 184 controls.<\/jats:p>\n                    <jats:p>APACHE: 125 patients with myocardial infarction (MI), 73 with ST-elevation MI and 52 with non-ST-elevation MI. Exclusion criteria: Intervention study participation, warfarin treatment and short life expectancy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Primary and secondary outcome measures<\/jats:title>\n                    <jats:p>Primary outcome was the association between baseline COL1\u03b11 and first-time major event of CAD, defined as fatal\/non-fatal MI or coronary revascularisation after 13 years. Secondary outcomes were the association between the collagen biomarkers PRO-C1 (N-terminal pro-peptide of type I collagen)\/C1M (matrix metalloproteinase-mediated degradation of type I collagen) and CAD; temporal change of COL1\u03b11 after acute MI up to 6 months and lastly, correlates between COL1\u03b11 and patient characteristics along with circulating markers of collagen metabolism.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>COL1\u03b11 levels were associated with CAD, both unadjusted (HR=0.69, 95% CI=0.56 to 0.87) and adjusted (HR=0.55, 95% CI=0.41 to 0.75). PRO-C1 was associated with CAD, unadjusted (HR=0.62, 95% CI=0.47 to 0.82) and adjusted (HR=0.61, 95% CI=0.43 to 0.86), while C1M was not. In patients with MI, COL1\u03b11 remained unchanged up to 6 months. COL1\u03b11 was correlated to PRO-C1, but not to C1M.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Plasma COL1\u03b11 was independently and inversely associated with CAD. Furthermore, COL1\u03b11 appeared to reflect collagen synthesis but not degradation. Future studies are needed to confirm whether COL1\u03b11 is a clinically useful biomarker of CAD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-073561","type":"journal-article","created":{"date-parts":[[2023,9,15]],"date-time":"2023-09-15T12:26:12Z","timestamp":1694780772000},"page":"e073561","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":7,"title":["Plasma type I collagen \u03b11 chain in relation to coronary artery disease: findings from a prospective population-based cohort and an acute myocardial infarction prospective cohort in Sweden"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4953-6124","authenticated-orcid":false,"given":"Filip","family":"Hammar\u00e9us","sequence":"first","affiliation":[{"name":"Department of Health Medicine and Caring Sciences, Linkoping University, Linkoping, 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