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Participants are now being followed up via linkage to national administrative healthcare databases (deaths, cancers and secondary care hospital activity).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Findings to date<\/jats:title>\n                  <jats:p>Enabling the creation of cohorts with minimal selection bias and loss to follow-up, the original case-control study registered all newly diagnosed cases of childhood cancer and their corresponding controls, regardless of their family\u2019s participation. Early findings based on the registered case population found marked survival variations with age and sex across subtypes and differences with deprivation among acute lymphoblastic leukaemia (ALL) survivors. More recently, comparing the health-activity patterns of the case and control populations revealed that survivors of childhood ALL experienced excess outpatient and inpatient activity across their teenage\/young adult years. Adding to increased risks of cancer and death and involving most clinical specialties, excesses were not related to routine follow-up monitoring and showed no signs of diminishing over time.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Future plans<\/jats:title>\n                  <jats:p>With annual linkage updates, the UKCCS\u2019s maturing population-based matched cohorts provide the foundation for tracking the health of individuals through their lifetime. Comparing the experience of childhood cancer survivors to that of unaffected general-population counterparts, this will include examining subsequent morbidity and mortality, secondary care hospital activity and the impact of deprivation on longer term outcomes.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-073712","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T22:01:11Z","timestamp":1700258471000},"page":"e073712","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Cohort profile: the United Kingdom Childhood Cancer Study (UKCCS) \u2013 a UK-wide population-based study examining the health of cancer survivors"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7603-3704","authenticated-orcid":false,"given":"Eve","family":"Roman","sequence":"first","affiliation":[{"name":"Department of Health Sciences, University of York, York, North Yorkshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7438-9982","authenticated-orcid":false,"given":"Eleanor","family":"Kane","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of York, York, North Yorkshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1111-966X","authenticated-orcid":false,"given":"Alexandra","family":"Smith","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of York, York, North Yorkshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7521-7402","authenticated-orcid":false,"given":"Debra","family":"Howell","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of York, York, North Yorkshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7715-1224","authenticated-orcid":false,"given":"Rebecca","family":"Sheridan","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of York, York, North Yorkshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jill","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Health Sciences, University of York, York, North Yorkshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audrey","family":"Bonaventure","sequence":"additional","affiliation":[{"name":"INSERM, Universit\u00e9 Paris Cit\u00e9 and Universit\u00e9 Sorbonne Paris Nord, Paris, \u00cele-de-France, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sally","family":"Kinsey","sequence":"additional","affiliation":[{"name":"Paediatric Haematology, Leeds Children's Hospital, Leeds, West Yorkshire, UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,11,17]]},"reference":[{"key":"2025101810592891000_13.11.e073712.1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70548-5"},{"key":"2025101810592891000_13.11.e073712.2","unstructured":"American Cancer Society . 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