{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T22:50:27Z","timestamp":1775170227529,"version":"3.50.1"},"reference-count":34,"publisher":"BMJ","issue":"8","license":[{"start":{"date-parts":[[2023,8,17]],"date-time":"2023-08-17T00:00:00Z","timestamp":1692230400000},"content-version":"unspecified","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"crossref","award":["No. ZYJC21007"],"award-info":[{"award-number":["No. ZYJC21007"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"crossref"}]},{"name":"West China Nursing Discipline Development Special Fund Project, Sichuan University","award":["HXHL21024"],"award-info":[{"award-number":["HXHL21024"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,8,1]]},"published-print":{"date-parts":[[2023,8]]},"abstract":"\n Objectives<\/jats:title>\n Perianal infection is a serious complication in patients undergoing chemotherapy for haematological malignancies. Therefore, we aimed to develop a predictive model to help medical staff promptly screen patients at a high risk of perianal infection during chemotherapy.<\/jats:p>\n <\/jats:sec>\n \n Design<\/jats:title>\n This was a single-centre prospective observational study.<\/jats:p>\n <\/jats:sec>\n \n Setting<\/jats:title>\n This study was conducted in a tertiary teaching hospital in Chengdu, China.<\/jats:p>\n <\/jats:sec>\n \n Participants<\/jats:title>\n The study sample comprised 850 patients with haematological malignancies who underwent chemotherapy at the department of haematology or our hospital between January 2021 and June 2022.<\/jats:p>\n <\/jats:sec>\n \n Interventions<\/jats:title>\n The included patients were randomly divided into training and validation groups in a 7:3 ratio. Based on the discharge diagnosis, patients with perianal infection were selected as the case group and the other patients were selected as the control group.<\/jats:p>\n <\/jats:sec>\n \n Outcome measure<\/jats:title>\n The main outcome measure was the occurrence of perianal infections.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A predictive model for perianal infections was established. A history of perianal infection, haemorrhoids, constipation and duration of diarrhoea were independent risk factors. The area under the curve of the The area under the receiver operating characteristic (ROC) curve for the training and validation groups were 0.784 (95% CI 0.727 to 0.841) and 0.789 (95% CI 0.818 to 0.885), respectively. Additionally, the model had good calibration in both the training and validation groups with a non-significant Hosmer-Lemeshow test (p=0.999\u2009and 0.482, respectively).<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The risk prediction model, including a history of perianal infection, history of haemorrhoids, constipation and duration of diarrhoea \u22653\u2009days of perianal infection in patients with haematological malignancies during chemotherapy, has good prediction reliability and can be helpful in guiding clinical medical staff in screening and early intervention of high-risk groups.<\/jats:p>\n <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-074196","type":"journal-article","created":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T07:57:07Z","timestamp":1692431827000},"page":"e074196","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Construction and validation of a risk prediction model for perianal infection in patients with haematological malignancies during chemotherapy: a prospective study in a tertiary hospital in China"],"prefix":"10.1136","volume":"13","author":[{"given":"Yingli","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Hematology, Sichuan University West China Hospital, Chengdu, Sichuan, China"},{"name":"Sichuan University West China Hospital School of Nursing, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuqin","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Hematology, Sichuan University West China Hospital, Chengdu, Sichuan, China"},{"name":"Sichuan University West China Hospital School of Nursing, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamei","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Hematology, Sichuan University West China Hospital, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Sichuan University West China Hospital, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1844-2777","authenticated-orcid":false,"given":"Taoyun","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Sichuan University West China Hospital, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Hematology, Sichuan University West China Hospital, Chengdu, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,8,18]]},"reference":[{"key":"2025121605060031000_13.8.e074196.1","doi-asserted-by":"crossref","first-page":"1354","DOI":"10.1093\/annonc\/mdy117","article-title":"Anti-infective vaccination strategies in patients with hematologic malignancies or solid tumors-guideline of the infectious diseases working party (AGIHO) of the German society for hematology and medical oncology (DGHO)","volume":"29","author":"Rieger","year":"2018","journal-title":"Ann Oncol"},{"key":"2025121605060031000_13.8.e074196.2","doi-asserted-by":"crossref","DOI":"10.4084\/MJHID.2022.051","article-title":"The role of white blood cell count in perianal pathologies: a retrospective analysis of hematologic malignancies","volume":"14","author":"Orhan","year":"2022","journal-title":"Mediterr J Hematol Infect 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To compare the clinical efficacy of diosmin tablets and Diyuhuaijiao pills in the treatment of stage I internal hemorrhoids. 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