{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T04:35:04Z","timestamp":1791866104028,"version":"4.3.4"},"reference-count":46,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T00:00:00Z","timestamp":1705017600000},"content-version":"unspecified","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"national natural science Foundation of China","doi-asserted-by":"crossref","award":["81872506"],"award-info":[{"award-number":["81872506"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,11,27]]},"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>We aimed to explore the epidemiological characteristics of suspected adenomyosis within a physical examination population in China.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Design<\/jats:title>\n                  <jats:p>A retrospective, nested case-control study; we matched healthy people and those with potential adenomyosis on a 1:2 ratio by age.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Setting<\/jats:title>\n                  <jats:p>A tertiary hospital health management centre.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Participants<\/jats:title>\n                  <jats:p>We included 15\u201360\u2009years old women who underwent at least one uterine examination from October 2017 to December 2020, excluding those who had undergone hysterectomy and menopause.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Primary and secondary outcome measures<\/jats:title>\n                  <jats:p>We estimated the incidence and prevalence rate of suspected adenomyosis. Conditional logistic regression was used to estimate associations between serum biomarkers and potential adenomyosis. Areas under the receiver-operating characteristic curves (AUC) were used to determine the cut-off point of the cancer antigen 125 (CA125) level for suspected adenomyosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 30\u2009629\u2009women had uterus-related imaging examinations; 877 had suspected adenomyosis. The standardised incidence and prevalence of suspected adenomyosis was 1.32% and 2.35%, respectively, for all age groups. The conditional logistic regression analysis results showed that total bilirubin\u226518.81\u2009\u00b5mol\/L (HR: 2.129; 95%\u2009CI 1.067 to 4.249; p&lt;0.0321) and CA125 levels (HR: 1.014; 95%\u2009CI 1.002 to 4.731; p&lt;0.0273) were positively correlated with onset of suspected adenomyosis; body mass index&gt;24\u2009kg\/m<jats:sup>2<\/jats:sup> (HR: 1.262; 95%\u2009CI 1.055 to 1.511; p&lt;0.0109), CA125 levels (HR: 1.007; 95%\u2009CI 1.006 to 1.009; p&lt;0.0001), and blood platelet levels (HR: 1.002; 95%\u2009CI 1 to 1.003; p&lt;0.0141) were positively correlated with potential adenomyosis. The optimal cut-off of CA125 for new suspected adenomyosis was 10.714\u2009U\/mL, with a sensitivity of 77.42%, specificity of 53.76%, and AUC of 0.7841 (95% CI 0.7276 to 0.8407).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>The disease burden of suspected adenomyosis remains huge and can be informed by biomarkers. The disease-specific threshold of CA125 will support further preventive strategy development in population.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>ChiCTR2100049520, 2021\/8\/2.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-074488","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T12:37:24Z","timestamp":1705063044000},"page":"e074488","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Epidemiological characteristics of suspected adenomyosis in the Chinese physical examination population: a nested case-control study"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8878-6180","authenticated-orcid":false,"given":"Yanyan","family":"Huang","sequence":"first","affiliation":[{"name":"Chongqing Medical 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