{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T04:30:26Z","timestamp":1778819426945,"version":"3.51.4"},"reference-count":43,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2023,11,18]],"date-time":"2023-11-18T00:00:00Z","timestamp":1700265600000},"content-version":"unspecified","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,10,20]]},"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Schizotypal disorder is associated with a high level of disability at an individual level and high societal costs. However, clinical recommendations for the treatment of schizotypal disorder are scarce and based on limited evidence. This review aims to synthesise the current evidence on treatment for schizotypal disorder making recommendations for clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This systematic review protocol follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. A systematic literature search will be performed in PsychArticles, Embase, Medline and Cochrane Central Register of Controlled Trials. Additionally, we will search for relevant articles manually. Inclusion criteria are published studies including individuals diagnosed with schizotypal personality disorder according to Diagnostic and Statistical Manual of Mental Disorders (DSM) criteria, or schizotypal disorder according to International Classification of Diseases (ICD) criteria. We will include interventional studies comprising any pharmacological and non-pharmacological treatment trials for patients with schizotypal disorder, and all relevant outcome measures will be reported. Risk of bias will be assessed by Cochrane risk-of-bias tools. Data will be synthesised using narrative or thematic analysis and, if suitable, through meta-analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>No original data will be collected as part of this study and ethics approval is, therefore, not applicable. The results will be disseminated through peer-reviewed publication and presented at international scientific meetings. We will aim at submitting the final paper for publication within 4 months of completion of analyses. Furthermore, this systematic review will inform clinicians and researchers on the current state of evidence on treatment for schizotypal disorder. Findings may guide proposals for further research and potentially guide recommendations for clinical practice using the Grading of Recommendations Assessment, Development and Evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD42022375001.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-075140","type":"journal-article","created":{"date-parts":[[2023,11,17]],"date-time":"2023-11-17T22:00:42Z","timestamp":1700258442000},"page":"e075140","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Treatment of schizotypal disorder: a protocol for a systematic review of the evidence and recommendations for clinical practice"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3277-4564","authenticated-orcid":false,"given":"Kristina Ballestad","family":"Gundersen","sequence":"first","affiliation":[{"name":"VIRTU research group, Copenhagen Research Centre for Mental Health, Hellerup, Denmark"},{"name":"Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark"},{"name":"Department of Psychology, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas Ros\u00e9n","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Mental Health Center Amager, University of Copenhagen, Copenhagen, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark"},{"name":"Centre for Youth Mental Health, The University of Melbourne, Melbourne, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katharina Oravsky","family":"Sandstr\u00f6m","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolai","family":"Albert","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark"},{"name":"Copenhagen Research Centre for Mental Health (CORE), Hellerup, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Polari","sequence":"additional","affiliation":[{"name":"Centre for Youth Mental Health, The University of Melbourne, Melbourne, Victoria, Australia"},{"name":"Orygen Specialist Program, Parkville, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f8rn H","family":"Ebdrup","sequence":"additional","affiliation":[{"name":"Center for Neuropsychiatric Schizophrenia Research (CNSR), Mental Health Centre Glostrup, University of Copenhagen, Glostrup, Denmark"},{"name":"Department of Clinical Medicine, University of Copenhagen, Faculty of Health and Medical Sciences, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barnaby","family":"Nelson","sequence":"additional","affiliation":[{"name":"Centre for Youth Mental Health, The University of Melbourne, Melbourne, Victoria, Australia"},{"name":"Orygen, Parkville, Victoria, Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louise Birkedal","family":"Glenth\u00f8j","sequence":"additional","affiliation":[{"name":"VIRTU research group, Copenhagen Research Centre for Mental Health, Hellerup, Denmark"},{"name":"Department of Psychology, University of Copenhagen, Copenhagen, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,11,17]]},"reference":[{"key":"2025121600052828000_13.11.e075140.1","unstructured":"Kraepelin E . 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