{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T22:28:02Z","timestamp":1765837682492,"version":"3.48.0"},"reference-count":38,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2023,12,21]],"date-time":"2023-12-21T00:00:00Z","timestamp":1703116800000},"content-version":"unspecified","delay-in-days":20,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515011673"],"award-info":[{"award-number":["2021A1515011673"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2022A1515011181"],"award-info":[{"award-number":["2022A1515011181"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81873673"],"award-info":[{"award-number":["81873673"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81900841"],"award-info":[{"award-number":["81900841"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,11,20]]},"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aims to evaluate the effect of congenital ectopia lentis (CEL) on functional vision and eye-related quality of life (ER-QOL) in children and their families using the Paediatric Eye Questionnaire (PedEyeQ).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A questionnaire survey administered via in-person interviews of patients with CEL and their parents.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>51 children with CEL and 53 visually normal controls accompanied by 1 parent completed the survey questionnaires for the study from March 2022 to September 2022.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome measures<\/jats:title>\n                    <jats:p>PedEyeQ domain scores. Functional vision and ER-QOL of children and their families were evaluated by calculating and comparing the Rasch domain scores of the PedEyeQ.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>PedEyeQ domain scores were significantly worse with CEL compared with controls (p&lt;0.01 for each), with the exception of the Proxy Social domain among children aged 0\u20134 years (p=0.283). Child PedEyeQ greatest differences were in the functional vision domain (5\u201311 years, \u221220 points (95%\u2009CI \u221227 to \u221212)) and frustration\/worry domain (12\u201317 years, \u221241 (95%\u2009CI \u221237 to \u22126)). Proxy PedEyeQ greatest differences were in the functional vision domain (0\u20134 years, \u221234 (95%\u2009CI \u221245 to \u221222)) and frustration\/worry domain (5\u201311 years, \u221227 (95%\u2009CI \u221239 to \u221214); 12\u201317 years, \u221237(95%\u2009CI (\u221248 to \u221226))). Parent PedEyeQ greatest difference was in the \u2018worry about child\u2019s eye condition\u2019 (\u221257 (95%\u2009CI (\u221263 to \u221251))).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>In this study, children with CEL had reduced functional vision and ER-QOL compared with controls. Parents of children with CEL also experience reduced quality of life.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-075222","type":"journal-article","created":{"date-parts":[[2023,12,22]],"date-time":"2023-12-22T00:06:22Z","timestamp":1703203582000},"page":"e075222","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of functional vision and eye-related quality of life in children with congenital ectopia lentis: a prospective cross-sectional study"],"prefix":"10.1136","volume":"13","author":[{"given":"Xiaolin","family":"Liang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, 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