{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:32:45Z","timestamp":1787236365557,"version":"build-2736575974"},"reference-count":41,"publisher":"BMJ","issue":"9","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"unspecified","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81473047"],"award-info":[{"award-number":["81473047"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2019J01316"],"award-info":[{"award-number":["2019J01316"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2023J01628"],"award-info":[{"award-number":["2023J01628"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,9,11]]},"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Our study aimed to explore the diagnostic value of triglyceride\u2013glucose (TyG) and its related parameters in metabolism-associated fatty liver disease (MAFLD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>A cross-sectional study of residents who attended medical checkups at the First Hospital of Nanping City, Fujian Medical University, between 2015 and 2017.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>One participation centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>2605 subjects met the inclusion\u2013exclusion criteria and were grouped according to whether they had MAFLD.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The TyG index and its associated parameters are positively associated with the risk of developing MAFLD (p&lt;0.001). Restriction cube spline analysis showed a significant dose\u2013response relationship between the TyG index and MAFLD. The risk of developing MAFLD increases significantly with a higher TyG index. After adjusting for confounders, this relationship remains (OR: 4.89, 95% CI 3.98 to 6.00). The areas under the receiver operating characteristic curves of the TyG index for MAFLD detection were 0.793 (0.774 to 0.812). The areas under the curve (AUC) of TyG-related parameters were improved, among which TyG-waist circumference (TyG-WC) showed the largest AUC for MAFLD detection (0.873, 95% CI 0.860 to 0.887). In addition, the best cut-off value of the TyG-WC was 716.743, with a sensitivity and specificity of 88.7% and 71.4%, respectively.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The TyG index effectively identifies MAFLD, and the TyG-related parameters improved the identification and diagnosis of MAFLD, suggesting that TyG-related parameters, especially TyG-WC, may be a useful marker for diagnosing MAFLD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-075413","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T13:42:05Z","timestamp":1695994925000},"page":"e075413","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":23,"title":["Diagnostic value of triglyceride\u2013glucose index and related parameters in metabolism-associated fatty liver disease in a Chinese population: a cross-sectional study"],"prefix":"10.1136","volume":"13","author":[{"given":"Rong","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Health Statistics, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weijiang","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hewei","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Lu","sequence":"additional","affiliation":[{"name":"Xiamen Customs, General Administration of Customs of the People's Republic of China, Xiamen, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuo","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shanghua","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Affiliated Nanping First Hospital, Fujian Medical University, Nanping, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhijian","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4795-7956","authenticated-orcid":false,"given":"Xian-E","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Health Statistics, Fujian Medical University, Fuzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,9,29]]},"reference":[{"key":"2025120521163650000_13.9.e075413.1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.09.003"},{"key":"2025120521163650000_13.9.e075413.2","doi-asserted-by":"crossref","first-page":"4574","DOI":"10.2174\/1381612825666190117102111","article-title":"Diagnosis of non-alcoholic fatty liver disease (NAFLD): current concepts","volume":"24","author":"Papatheodoridi","year":"2018","journal-title":"Curr Pharm Des"},{"key":"2025120521163650000_13.9.e075413.3","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.03.039"},{"key":"2025120521163650000_13.9.e075413.4","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.2147\/DMSO.S356371","article-title":"Lipid-lowering responses to dyslipidemia determine the efficacy on liver enzymes in metabolic dysfunction-associated fatty liver disease with hepatic injuries: a prospective cohort study","volume":"15","author":"Liao","year":"2022","journal-title":"Diabetes Metab Syndr Obes"},{"key":"2025120521163650000_13.9.e075413.5","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2022.1047794","article-title":"Association of metabolic dysfunction-associated fatty liver disease, type 2 diabetes mellitus, and metabolic goal achievement with risk of chronic kidney disease","volume":"10","author":"Su","year":"2022","journal-title":"Front Public Health"},{"key":"2025120521163650000_13.9.e075413.6","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5210870","article-title":"The imbalance of mitochondrial homeostasis of peripheral blood-derived macrophages mediated by MAFLD may impair the walking ability of elderly patients with osteopenia","volume":"2022","author":"Wang","year":"2022","journal-title":"Oxid Med Cell Longev"},{"key":"2025120521163650000_13.9.e075413.7","doi-asserted-by":"publisher","DOI":"10.2337\/dc16-1017"},{"key":"2025120521163650000_13.9.e075413.8","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2011.08.001"},{"key":"2025120521163650000_13.9.e075413.9","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.3"},{"key":"2025120521163650000_13.9.e075413.10","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2019.07.013"},{"key":"2025120521163650000_13.9.e075413.11","doi-asserted-by":"crossref","first-page":"41047","DOI":"10.1039\/D0RA06577C","article-title":"Early detection of metabolic changes in drug-induced steatosis using metabolomics approaches","volume":"10","author":"Yong","year":"2020","journal-title":"RSC Adv"},{"key":"2025120521163650000_13.9.e075413.12","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.12.036"},{"key":"2025120521163650000_13.9.e075413.13","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.3748\/wjg.v25.i11.1307","article-title":"Noninvasive evaluation of non-alcoholic fatty liver disease: current evidence and practice","volume":"25","author":"Zhou","year":"2019","journal-title":"World J Gastroenterol"},{"key":"2025120521163650000_13.9.e075413.14","doi-asserted-by":"crossref","first-page":"2683","DOI":"10.1111\/liv.15439","article-title":"Isotemporal substitution of different behaviour patterns with the presence of MAFLD in Chinese adults","volume":"42","author":"Wang","year":"2022","journal-title":"Liver Int"},{"key":"2025120521163650000_13.9.e075413.15","doi-asserted-by":"crossref","first-page":"977625","DOI":"10.3389\/fendo.2022.977625","article-title":"The lipid accumulation product is a powerful tool to diagnose metabolic dysfunction-associated fatty liver disease in the United States adults","volume":"13","author":"Li","year":"2022","journal-title":"Front Endocrinol"},{"key":"2025120521163650000_13.9.e075413.16","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2020.00220","article-title":"Risk prediction for non-alcoholic fatty liver disease based on biochemical and dietary variables in a Chinese Han population","volume":"8","author":"Pan","year":"2020","journal-title":"Front Public Health"},{"key":"2025120521163650000_13.9.e075413.17","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/607364","article-title":"Association of metabolic syndrome with the adiponectin to homeostasis model assessment of insulin resistance ratio","volume":"2015","author":"Ding","year":"2015","journal-title":"Mediators Inflamm"},{"key":"2025120521163650000_13.9.e075413.18","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.1031259","article-title":"Triglyceride glucose index and atherogenic index of plasma for predicting colorectal neoplasms in patients without cardiovascular diseases","volume":"12","author":"Han","year":"2022","journal-title":"Front Oncol"},{"key":"2025120521163650000_13.9.e075413.19","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-019-0957-3","article-title":"High triglyceride-glucose index is associated with poor prognosis in patients with acute ST-elevation myocardial infarction after percutaneous coronary intervention","volume":"18","author":"Luo","year":"2019","journal-title":"Cardiovasc Diabetol"},{"key":"2025120521163650000_13.9.e075413.20","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-019-0982-2","article-title":"Use of the triglyceride-glucose index (Tyg) in cardiovascular disease patients","volume":"19","author":"Alizargar","year":"2020","journal-title":"Cardiovasc Diabetol"},{"key":"2025120521163650000_13.9.e075413.21","doi-asserted-by":"crossref","first-page":"3167","DOI":"10.2147\/DMSO.S383907","article-title":"Association between triglyceride-glucose index and risk of metabolic dysfunction-associated fatty liver disease: a cohort study","volume":"15","author":"Zhang","year":"2022","journal-title":"Diabetes Metab Syndr Obes"},{"key":"2025120521163650000_13.9.e075413.22","doi-asserted-by":"crossref","DOI":"10.3390\/nu14234969","article-title":"The diagnostic and prognostic value of the Triglyceride-glucose index in metabolic dysfunction-associated fatty liver disease (MAFLD): a systematic review and meta-analysis","volume":"14","author":"Wang","year":"2022","journal-title":"Nutrients"},{"key":"2025120521163650000_13.9.e075413.23","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2023.1083032","article-title":"Prediction of MAFLD and NAFLD using different screening indexes: a cross-sectional study in U.S","volume":"14","author":"Peng","year":"2023","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2025120521163650000_13.9.e075413.24","doi-asserted-by":"crossref","DOI":"10.1186\/s12876-021-01688-7","article-title":"Association of meat consumption with NAFLD risk and liver-related biochemical indexes in older Chinese: a cross-sectional study","volume":"21","author":"Peng","year":"2021","journal-title":"BMC Gastroenterol"},{"key":"2025120521163650000_13.9.e075413.25","first-page":"1235","article-title":"Analysis of the prevalence and influencing factors of non-alcoholic fatty liver disease in staff","volume":"25","author":"Xiane Peng","year":"2009","journal-title":"China Public Health"},{"key":"2025120521163650000_13.9.e075413.26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0149731","article-title":"Triglyceride glucose-body mass index is a simple and clinically useful surrogate marker for insulin resistance in nondiabetic individuals","volume":"11","author":"Er","year":"2016","journal-title":"PLoS One"},{"key":"2025120521163650000_13.9.e075413.27","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-022-01681-8","article-title":"Comparison of the effects of triglyceride variability and exposure estimate on clinical prognosis in diabetic patients","volume":"21","author":"Koh","year":"2022","journal-title":"Cardiovasc Diabetol"},{"key":"2025120521163650000_13.9.e075413.28","doi-asserted-by":"crossref","DOI":"10.3389\/fpubh.2022.810185","article-title":"Health-related quality of life and its related factors in survivors of stroke in rural China: a large-scale cross-sectional study","volume":"10","author":"Mei","year":"2022","journal-title":"Front Public Health"},{"key":"2025120521163650000_13.9.e075413.29","doi-asserted-by":"crossref","DOI":"10.3892\/mco.2021.2488","article-title":"Serine palmitoyltransferase long chain subunit 3 is associated with hepatocellular carcinoma in patients with NAFLD","volume":"16","author":"Ijuin","year":"2022","journal-title":"Mol Clin Oncol"},{"key":"2025120521163650000_13.9.e075413.30","doi-asserted-by":"crossref","first-page":"1818","DOI":"10.3390\/ijerph17061818","article-title":"Prevalence and risk factors of metabolic associated fatty liver disease in Xinxiang, China","volume":"17","author":"Li","year":"2020","journal-title":"IJERPH"},{"key":"2025120521163650000_13.9.e075413.31","doi-asserted-by":"crossref","first-page":"1163682","DOI":"10.3389\/fendo.2023.1163682","article-title":"Comparison between traditional and new obesity measurement index for screening metabolic associated fatty liver disease","volume":"14","author":"Wang","year":"2023","journal-title":"Front Endocrinol"},{"key":"2025120521163650000_13.9.e075413.32","doi-asserted-by":"crossref","DOI":"10.1186\/s12902-022-01030-6","article-title":"Fatty liver index for hyperuricemia diagnosis: a community-based cohort study","volume":"22","author":"Qu","year":"2022","journal-title":"BMC Endocr Disord"},{"key":"2025120521163650000_13.9.e075413.33","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1116425","article-title":"Elevated triglyceride-glucose index predicts mortality following endovascular abdominal aortic aneurysm repair","volume":"10","author":"Li","year":"2023","journal-title":"Front Nutr"},{"key":"2025120521163650000_13.9.e075413.34","doi-asserted-by":"crossref","DOI":"10.1186\/s12933-022-01511-x","article-title":"Triglyceride-glucose index as a marker in cardiovascular diseases: landscape and limitations","volume":"21","author":"Tao","year":"2022","journal-title":"Cardiovasc Diabetol"},{"key":"2025120521163650000_13.9.e075413.35","doi-asserted-by":"crossref","first-page":"383","DOI":"10.2147\/DMSO.S342505","article-title":"Associations between GGT\/HDL and MAFLD: a cross-sectional study","volume":"Volume 15","author":"Xing","year":"2022","journal-title":"DMSO"},{"key":"2025120521163650000_13.9.e075413.36","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15041308","article-title":"Non-parenchymal cells and the extracellular matrix in hepatocellular carcinoma in non-alcoholic fatty liver disease","volume":"15","author":"van Son","year":"2023","journal-title":"Cancers (Basel)"},{"key":"2025120521163650000_13.9.e075413.37","doi-asserted-by":"crossref","DOI":"10.1186\/s12944-021-01561-2","article-title":"The usefulness of obesity and lipid-related indices to predict the presence of non-alcoholic fatty liver disease","volume":"20","author":"Sheng","year":"2021","journal-title":"Lipids Health Dis"},{"key":"2025120521163650000_13.9.e075413.38","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/jdi.13966","article-title":"Diagnostic ability using fatty liver and metabolic markers for metabolic-associated fatty liver disease stratified by metabolic\/glycemic abnormalities","volume":"14","author":"Okada","year":"2023","journal-title":"J Diabetes Investig"},{"key":"2025120521163650000_13.9.e075413.39","doi-asserted-by":"crossref","DOI":"10.1186\/s12944-018-0856-8","article-title":"Localization of fat depots and cardiovascular risk","volume":"17","author":"Gruzdeva","year":"2018","journal-title":"Lipids Health Dis"},{"key":"2025120521163650000_13.9.e075413.40","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1089\/met.2020.0109","article-title":"Triglyceride glucose index and related parameters (Triglyceride glucose-body mass index and Triglyceride glucose-waist circumference) identify non-alcoholic fatty liver and liver fibrosis in individuals with overweight\/obesity","volume":"19","author":"Khamseh","year":"2021","journal-title":"Metab Syndr Relat Disord"},{"key":"2025120521163650000_13.9.e075413.41","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.951689","article-title":"Potential screening indicators for early diagnosis of NAFLD\/MAFLD and liver fibrosis: triglyceride glucose index-related parameters","volume":"13","author":"Xue","year":"2022","journal-title":"Front Endocrinol (Lausanne)"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2023-075413","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T05:16:49Z","timestamp":1764998209000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2023-075413"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9]]},"references-count":41,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2023,9,29]]},"published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1136\/bmjopen-2023-075413"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2023-075413","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"value":"2044-6055","type":"print"},{"value":"2044-6055","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9]]}}}