{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T11:28:19Z","timestamp":1767007699949,"version":"3.48.0"},"reference-count":25,"publisher":"BMJ","issue":"10","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"unspecified","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,9,19]]},"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Central nervous system tuberculosis (CNSTB) is a severe condition, sometimes associated with a poor prognosis. Early diagnosis of CNSTB remains challenging, considering that conventional methods lack sensitivity or might lead to certain side effects. Herein, we presented a protocol for a systematic review and meta-analysis to assess the diagnostic efficacy of MRI for CNSTB.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>SinoMed, Wanfang database, China National Knowledge Infrastructure, Embase, the Cochrane Library and PubMed will be searched to identify studies reporting on the use of MRI in the diagnosis of CNSTB from database inception to December 2023. The following keywords will be applied: \u2018Intracranial tuberculosis\u2019, \u2018Cerebral tuberculosis\u2019, \u2018Central nervous system tuberculosis\u2019, \u2018Spinal tuberculous arachnoiditis\u2019 and \u2018Magnetic Resonance Imaging\u2019. Studies that evaluate the diagnostic accuracy of MRI for the diagnosis of CNSTB and report clear reference criteria will be included. Studies from which full true positive, false positive, false negative and true negative values cannot be extracted, those published in languages other than English or Chinese, abstracts not reporting the full text, and case reports will be excluded. Quality Assessment of Diagnostic Accuracy Studies (QUADAS-2) will be used to evaluate the methodological quality of each included study. Stata V.15.0 and RevMan V.5.3 will be used to perform a meta-analysis and generate forest plots and summary receiver operating characteristic curves. In case of significant heterogeneity between studies, possible sources of heterogeneity will be explored through subgroup and meta-regression analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This research is based on public databases and does not require ethical approval. Results will be submitted for publication in a peer-reviewed journal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD42023415690.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-075745","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T12:01:36Z","timestamp":1696507296000},"page":"e075745","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Diagnostic validity of MRI for central nervous system tuberculosis: protocol for a systematic review and meta-analysis"],"prefix":"10.1136","volume":"13","author":[{"given":"Yanqin","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Nursing, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liwei","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Nursing, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinjuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nursing, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-5038-6207","authenticated-orcid":false,"given":"Huihong","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Nursing, Hangzhou Red Cross Hospital, Hangzhou, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,10,5]]},"reference":[{"key":"2025121510130256000_13.10.e075745.1","unstructured":"World Health Organization . 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