{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:34:20Z","timestamp":1765010060275,"version":"3.46.0"},"reference-count":19,"publisher":"BMJ","issue":"6","license":[{"start":{"date-parts":[[2024,6,25]],"date-time":"2024-06-25T00:00:00Z","timestamp":1719273600000},"content-version":"unspecified","delay-in-days":24,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Science Foundation for Young Scholars of Sichuan Provincial People\u2019s Hospital","award":["NO. 2022QN18"],"award-info":[{"award-number":["NO. 2022QN18"]}]},{"name":"Subject Founds of Health Care for Cadres of Sichuan Province","award":["NO. 2022-220"],"award-info":[{"award-number":["NO. 2022-220"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,2,20]]},"published-print":{"date-parts":[[2024,6]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>HIV infection is one of the complex aetiologies of non-Hodgkin\u2019s lymphoma (NHL). However, the contribution of HIV to burden of NHL across time and region has not yet been comprehensively reported and quantified. Thus, this study aims to evaluate the relative risk of NHL in individuals with HIV infection compared with those without by performing a comprehensive meta-analysis. Additionally, we intend to further estimate quantitatively the degree of HIV contributing to burden of NHL using population attributable fraction (PAF) modelling analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This study will screen a mass of records searched from four electronic databases (PubMed, Embase, Cochrane Library and Web of Science). The main outcomes are specific effect values and corresponding 95% CIs for NHL among population with HIV infection compared with those without to quantify the association between HIV infection and NHL. After quality assessment and data extraction, we will undertake a meta-analysis to calculate the pooled risk ratio (RR). Furthermore, PAF calculation based on pooled RR combines with number of age-specific disability-adjusted life year (DALY) and HIV prevalence data (aged \u226515 years old) from 1990 to 2019, at global, regional and country levels. We will calculate the PAF, HIV-associated DALY number and age-standardised rate to quantify the burden of HIV-associated NHL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This study is based on published articles; thus, the ethic approval is not essential. In addition, we intend to publish the results on peer-reviewed journals for more discussion. We believe that research on estimating global burden of NHL can provide valuable insights for developing targeted prevention and control strategies, thereby achieving significant benefits.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>PROSPERO registration number<\/jats:title>\n                    <jats:p>CRD 42023404150.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-075933","type":"journal-article","created":{"date-parts":[[2024,6,26]],"date-time":"2024-06-26T02:47:05Z","timestamp":1719370025000},"page":"e075933","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Global and regional burden estimation of HIV-associated non-Hodgkin\u2019s lymphoma: a meta-analysis and modelling analysis protocol"],"prefix":"10.1136","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4834-8085","authenticated-orcid":false,"given":"Yan","family":"Chen","sequence":"first","affiliation":[{"name":"School of Public Health, Southwest Medical University, Luzhou, Sichuan Province, China"},{"name":"Department of Health Management Center & Institute of Health Management, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaochen","family":"Sun","sequence":"additional","affiliation":[{"name":"School of Public Health, Southwest Medical University, Luzhou, Sichuan Province, China"},{"name":"Department of Health Management Center & Institute of Health Management, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ping","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Health Management Center & Institute of Health Management, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuping","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Health Management Center & Institute of Health Management, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengwei","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Health Management Center & Institute of Health Management, University of Electronic Science and Technology of China, Chengdu, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunli","family":"Ye","sequence":"additional","affiliation":[{"name":"School of Public Health, Southwest Medical University, Luzhou, Sichuan Province, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,6,25]]},"reference":[{"key":"2025120600311906000_14.6.e075933.1","unstructured":"Sapkota S , Shaikh H . Non-Hodgkin lymphoma. Treasure Island (FL) ineligible companies: StatPearls, 2023."},{"key":"2025120600311906000_14.6.e075933.2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"2025120600311906000_14.6.e075933.3","article-title":"Epidemiology of non-Hodgkin\u2019s lymphoma","volume":"9","author":"Thandra","year":"2021","journal-title":"Med Sci (Basel)"},{"key":"2025120600311906000_14.6.e075933.4","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"2025120600311906000_14.6.e075933.5","doi-asserted-by":"publisher","DOI":"10.1007\/s00277-004-0939-7"},{"key":"2025120600311906000_14.6.e075933.6","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a034819","article-title":"Kobetz EK: epidemiology and etiology of leukemia and lymphoma","volume":"10","author":"Bispo","year":"2020","journal-title":"Cold Spring Harb Perspect Med"},{"key":"2025120600311906000_14.6.e075933.7","doi-asserted-by":"crossref","first-page":"e633","DOI":"10.1016\/S2542-5196(21)00149-2","article-title":"Benzene exposure and non-Hodgkin lymphoma: a systematic review and meta-analysis of human studies","volume":"5","author":"Rana","year":"2021","journal-title":"Lancet Planet Health"},{"key":"2025120600311906000_14.6.e075933.8","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(03)00983-5"},{"key":"2025120600311906000_14.6.e075933.9","doi-asserted-by":"publisher","DOI":"10.3851\/IMP1462"},{"key":"2025120600311906000_14.6.e075933.10","first-page":"S34","article-title":"Impact of potent antiretroviral therapy on the incidence of Kaposi\u2019s sarcoma and non-Hodgkin\u2019s Lymphomas among HIV-1-infected individuals","volume":"21 Suppl 1","author":"Jacobson","year":"1999","journal-title":"J Acquir Immune Defic Syndr"},{"key":"2025120600311906000_14.6.e075933.11","doi-asserted-by":"publisher","DOI":"10.1097\/QAD.0b013e3282f2705d"},{"key":"2025120600311906000_14.6.e075933.12","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/hiv.12965","article-title":"Plasmablastic lymphoma in Johannesburg, South Africa, in the era of widescale antiretroviral therapy use","volume":"22","author":"Vaughan","year":"2021","journal-title":"HIV Med"},{"key":"2025120600311906000_14.6.e075933.13","doi-asserted-by":"crossref","DOI":"10.1186\/2046-4053-4-1","article-title":"Group P-P: preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) 2015 statement","volume":"4","author":"Moher","year":"2015","journal-title":"Syst Rev"},{"key":"2025120600311906000_14.6.e075933.14","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.comppsych.2015.05.001","article-title":"Prevalence of suicide attempts among Chinese adolescents: A meta-analysis of cross-sectional studies","volume":"61","author":"Hu","year":"2015","journal-title":"Compr Psychiatry"},{"key":"2025120600311906000_14.6.e075933.15","doi-asserted-by":"publisher","DOI":"10.1002\/sim.1186"},{"key":"2025120600311906000_14.6.e075933.16","doi-asserted-by":"publisher","DOI":"10.1136\/bjsports-2020-101977"},{"key":"2025120600311906000_14.6.e075933.17","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/S0140-6736(20)30977-6","article-title":"Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019: a comprehensive demographic analysis for the global burden of disease study 2019","volume":"396","author":"Wang","year":"2020","journal-title":"The Lancet"},{"key":"2025120600311906000_14.6.e075933.18","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.transci.2013.07.014","article-title":"Epidemiology of non-Hodgkin lymphoma","volume":"49","author":"Skrabek","year":"2013","journal-title":"Transfus Apher Sci"},{"key":"2025120600311906000_14.6.e075933.19","unstructured":"UNAIDS IN DANGER . UNAIDS global AIDS update 2022. UNAIDS; 2022. Available: https:\/\/www.unaids.org\/en\/resources\/documents\/2022\/in-danger-global-aids-update [Accessed 14 May 2023]."}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2023-075933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T08:31:29Z","timestamp":1765009889000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2023-075933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":19,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,6,25]]},"published-print":{"date-parts":[[2024,6]]}},"alternative-id":["10.1136\/bmjopen-2023-075933"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2023-075933","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"type":"print","value":"2044-6055"},{"type":"electronic","value":"2044-6055"}],"subject":[],"published":{"date-parts":[[2024,6]]}}}