{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T17:42:43Z","timestamp":1760809363631,"version":"build-2065373602"},"reference-count":18,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2024,1,19]],"date-time":"2024-01-19T00:00:00Z","timestamp":1705622400000},"content-version":"unspecified","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"Danish Neurosurgical Society","award":["R405-2022-118-CG"],"award-info":[{"award-number":["R405-2022-118-CG"]}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R405-2022-118-CG"],"award-info":[{"award-number":["R405-2022-118-CG"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2024,1,8]]},"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>Intraventricular haemorrhage (IVH) is associated with high morbidity and mortality. External ventricular drainage (EVD) has been shown to decrease mortality. Although EVD is widely used, outcome and complication rates in EVD-treated patients with IVH are not fully elucidated. This study aims to describe EVD complication rates and outcomes in patients with primary and secondary IVH at two university hospitals in Denmark. The study will provide a historical reference of relevant endpoints for use in future clinical trials involving patients with IVH.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>This descriptive, multicentre registry study included adult patients (age 18+) with primary or secondary IVH and treated with at least one EVD between 2017 and 2021 at Aarhus University Hospital or Odense University Hospital. Patients are identified using the Danish National Patient Register. Data are collected and recorded from patient medical records. Relevant descriptive statistics and correlation analyses will be applied.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Ethics and dissemination<\/jats:title>\n                  <jats:p>Ethical approval and authorisation to access, store and analyse data have been obtained (Central Denmark Region Committee on Health Research Ethics). The research lead will present the results of the study. Data will be reported according to the Strengthening the Reporting of Observational Studies in Epidemiology and results submitted for publication in peer-reviewed journals.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-075997","type":"journal-article","created":{"date-parts":[[2024,1,18]],"date-time":"2024-01-18T22:15:32Z","timestamp":1705616132000},"page":"e075997","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Descriptive registry study on outcome and complications of external ventricular drainage treatment of intraventricular haemorrhage in a Danish cohort: a study protocol"],"prefix":"10.1136","volume":"14","clinical-trial-number":[{"clinical-trial-number":"nct05204849","registry":"10.18810\/clinical-trials-gov"}],"author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4008-853X","authenticated-orcid":false,"given":"Chenghao","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mette","family":"Haldrup","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mads","family":"Rasmussen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"},{"name":"Department of Anesthesiology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stig","family":"Dyrskog","sequence":"additional","affiliation":[{"name":"Department of Intensive Care, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claus Ziegler","family":"Simonsen","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"},{"name":"Department of Neurology, Aarhus University Hospital, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mads Hjortdal","family":"Gr\u00f8nh\u00f8j","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Odense University Hospital, Odense, Denmark"},{"name":"Clinical Institute, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Frantz Rom","family":"Poulsen","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Odense University Hospital, Odense, Denmark"},{"name":"Clinical Institute, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5583-9484","authenticated-orcid":false,"given":"Thor","family":"Busse","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Odense University Hospital, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joakim","family":"Wismann","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Odense University Hospital, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Birgit","family":"Debrabant","sequence":"additional","affiliation":[{"name":"Department of Mathematics and Computer Science, University of Southern Denmark, Odense, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4285-8171","authenticated-orcid":false,"given":"Anders Rosendal","family":"Korshoej","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Aarhus University Hospital, Aarhus, Denmark"},{"name":"Department of Clinical Medicine, Aarhus University, Aarhus, Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,1,18]]},"reference":[{"key":"2025101810125356000_14.1.e075997.1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.55.7.546"},{"key":"2025101810125356000_14.1.e075997.2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)60371-8"},{"key":"2025101810125356000_14.1.e075997.3","unstructured":"Monta\u00f1o A , Hanley DF , Hemphill JC . Chapter 13 - hemorrhagic stroke. In: Hetts SW , Cooke DL , eds. Handbook of Clinical Neurology. Elsevier, 2021: 229\u201348. Available: https:\/\/www.sciencedirect.com\/science\/article\/pii\/B9780444640345000195"},{"key":"2025101810125356000_14.1.e075997.4","doi-asserted-by":"crossref","unstructured":"Poon MTC , Bell SM , Al-Shahi Salman R . Epidemiology of intracerebral haemorrhage. In: Toyoda K , Anderson CS , Mayer SA , eds. Frontiers of Neurology and Neuroscience. S. Karger AG, 2016: 1\u201312. doi:10.1159\/isbn.978-3-318-05597-9","DOI":"10.1159\/000437109"},{"key":"2025101810125356000_14.1.e075997.5","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(09)70340-0"},{"key":"2025101810125356000_14.1.e075997.6","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2019.00217","article-title":"Intraventricular hemorrhage severity as a predictor of outcome in intracerebral hemorrhage","volume":"10","author":"Trifan","year":"2019","journal-title":"Front Neurol"},{"key":"2025101810125356000_14.1.e075997.7","doi-asserted-by":"crossref","DOI":"10.1186\/s12883-021-02505-0","article-title":"Intraventricular hemorrhage clot clearance rate as an outcome predictor in patients with aneurysmal subarachnoid hemorrhage: a retrospective study","volume":"21","author":"Park","year":"2021","journal-title":"BMC Neurol"},{"key":"2025101810125356000_14.1.e075997.8","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1995.00540360071018"},{"key":"2025101810125356000_14.1.e075997.9","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.108.535419"},{"key":"2025101810125356000_14.1.e075997.10","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1136\/svn-2015-000003","article-title":"Mechanisms of hydrocephalus after intraventricular haemorrhage in adults","volume":"1","author":"Bu","year":"2016","journal-title":"Stroke Vasc Neurol"},{"key":"2025101810125356000_14.1.e075997.11","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.115.009713"},{"key":"2025101810125356000_14.1.e075997.12","doi-asserted-by":"crossref","first-page":"1805","DOI":"10.3171\/2015.5.JNS15299","article-title":"The burden and risk factors of ventriculostomy occlusion in a high-volume cerebrovascular practice: results of an ongoing prospective database","volume":"124","author":"Fargen","year":"2016","journal-title":"J Neurosurg"},{"key":"2025101810125356000_14.1.e075997.13","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1016\/j.wneu.2019.10.105","article-title":"Complications, and costs associated with external ventricular drainage catheter obstruction","volume":"134","author":"Aten","year":"2020","journal-title":"World Neurosurg"},{"key":"2025101810125356000_14.1.e075997.14","doi-asserted-by":"publisher","DOI":"10.1097\/00006123-200207000-00024"},{"key":"2025101810125356000_14.1.e075997.15","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajic.2020.06.087","article-title":"Risk factors associated with external ventricular drain associated infections","volume":"48","author":"Sabnis","year":"2020","journal-title":"Am J Infect Control"},{"key":"2025101810125356000_14.1.e075997.16","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.wneu.2023.01.021","article-title":"Treatment of intraventricular hemorrhage with external ventricular drainage and Fibrinolysis: a comprehensive systematic review and meta-analysis of complications and outcome","volume":"174","author":"Haldrup","year":"2023","journal-title":"World Neurosurg"},{"key":"2025101810125356000_14.1.e075997.17","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1007\/s00701-016-2863-8","article-title":"Fewer complications with bolt-connected than tunneled external ventricular drainage","volume":"158","author":"Jensen","year":"2016","journal-title":"Acta Neurochir (Wien)"},{"key":"2025101810125356000_14.1.e075997.18","doi-asserted-by":"crossref","DOI":"10.1186\/s13063-022-07043-9","article-title":"Study protocol for ACTIVE study: safety and feasibility evaluation of external ventricular drainage with ACTIVE fluid exchange in Intraventricular hemorrhage\u2014a phase 2, multi-center, randomized controlled trial","volume":"23","author":"Haldrup","year":"2022","journal-title":"Trials"}],"container-title":["BMJ Open"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/syndication.highwire.org\/content\/doi\/10.1136\/bmjopen-2023-075997","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T17:12:58Z","timestamp":1760807578000},"score":1,"resource":{"primary":{"URL":"https:\/\/bmjopen.bmj.com\/lookup\/doi\/10.1136\/bmjopen-2023-075997"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":18,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2024,1,18]]},"published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1136\/bmjopen-2023-075997"],"URL":"https:\/\/doi.org\/10.1136\/bmjopen-2023-075997","relation":{},"ISSN":["2044-6055","2044-6055"],"issn-type":[{"type":"print","value":"2044-6055"},{"type":"electronic","value":"2044-6055"}],"subject":[],"published":{"date-parts":[[2024,1]]}}}