{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T06:20:34Z","timestamp":1793082034610,"version":"4.5.0"},"reference-count":66,"publisher":"BMJ","issue":"1","license":[{"start":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T00:00:00Z","timestamp":1705363200000},"content-version":"unspecified","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"the Incubation Fund for Scientific Research and Innovation of Leading Talents of Unnamed Nursing of Peking University","award":["LJRC22YB04"],"award-info":[{"award-number":["LJRC22YB04"]}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81972158"],"award-info":[{"award-number":["81972158"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102661"],"award-info":[{"award-number":["82102661"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2020YFC2008801"],"award-info":[{"award-number":["2020YFC2008801"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,12,18]]},"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The objective of this study is to delineate disparities between patients with knee osteoarthritis (KOA) based on obesity status, investigate the interplay among body composition, physical activity and knee pain\/function in patients with KOA and conduct subgroup analyses focusing on those with KOA and obesity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cross-sectional study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Residents of eight communities in Shijiazhuang, Hebei Province, China, were surveyed from March 2021 to November 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>178 patients with symptomatic KOA aged 40 years or older were included.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcomes and measures<\/jats:title>\n                    <jats:p>\n                      The primary outcome measure was knee pain, assessed using the Western Ontario and McMaster Universities Osteoarthritis Index-pain (WOMAC-P) scale. Secondary outcome measures included function, evaluated through the WOMAC-function (WOMAC-F) scale and the Five-Time-Sit-to-Stand Test (FTSST). Data analysis involved t-tests, Wilcoxon rank-sum tests, \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      tests, linear and logistical regression analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Participants (n=178) were 41\u201380 years of age (median: 65, P25\u2013P75: 58\u201370), and 82% were female. Obese patients (n=103) had worse knee pain and self-reported function (p&lt;0.05). In general patients with KOA, body fat mass was positively associated with bilateral knee pain (\u03b2=1.21 (95% CI 0.03 to 0.15)), WOMAC-P scores (\u03b2=0.25 (95% CI 0.23 to 1.22)), WOMAC-F scores (\u03b2=0.28 (95% CI 0.35 to 1.29)) and FTSST (\u03b2=0.19 (95% CI 0.03 to 0.42)), moderate-intensity to low-intensity physical activity was negatively associated with bilateral knee pain (\u03b2=\u22120.80 (95% CI \u22120.10 to \u20130.01)) and Skeletal Muscle Index (SMI) was negatively associated with WOMAC-F scores (\u03b2=\u22120.16 (95% CI \u22120.66 to \u20130.03)). In patients with KOA and obesity, SMI was negatively associated with FTSST (\u03b2=\u22120.30 (95% CI \u22123.94 to \u20130.00)).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Patients with KOA and obesity had worse knee pain and self-reported function compared with non-obese patients. Greater fat mass, lower muscle mass and lower moderate-intensity to low-intensity physical activity were associated with increased knee pain and poor self-reported function. More skeletal muscle mass was associated with the improvement of objective function.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-076043","type":"journal-article","created":{"date-parts":[[2024,1,17]],"date-time":"2024-01-17T04:45:13Z","timestamp":1705466713000},"page":"e076043","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Association of body composition and physical activity with pain and function in knee osteoarthritis patients: a cross-sectional study"],"prefix":"10.1136","volume":"14","author":[{"given":"Beibei","family":"Tong","sequence":"first","affiliation":[{"name":"Peking University School of Nursing, Peking University, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbo","family":"Chen","sequence":"additional","affiliation":[{"name":"Nursing Department of Peking University Third Hospital, Peking University Third Hospital, Beijing, 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