{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T20:02:40Z","timestamp":1785268960545,"version":"3.55.0"},"reference-count":59,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T00:00:00Z","timestamp":1700352000000},"content-version":"unspecified","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100024386","name":"Mississippi Division of Medicaid","doi-asserted-by":"crossref","award":["N\/A"],"award-info":[{"award-number":["N\/A"]}],"id":[{"id":"10.13039\/100024386","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,10,26]]},"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess if the antecedent statin use was associated with all-cause death among COVID-19 patients enrolled in Medicaid.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Cohort study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Mississippi Medicaid population.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>This study included 10\u2009792 Mississippi Medicaid-enrolled patients between 18 and 64 years of age with a confirmed COVID-19 diagnosis from March 2020 to June 2021.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Intervention<\/jats:title>\n                    <jats:p>Antecedent statin use, which was determined by a record of statin prescription in the 90-day period prior to the COVID diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Main outcome measures<\/jats:title>\n                    <jats:p>The outcomes of interest included mortality from all cause within 30 days, 60 days and 90 days after index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 10\u2009792 patients with COVID-19 met the inclusion and exclusion criteria, with 13.1% of them being antecedent statin users. Statin users were matched 1:1 with non-users based on age, sex, race, comorbidities and medication use by propensity score matching. In total, the matched cohort consisted of 1107 beneficiaries in each group. Multivariable logistic regression showed that statin users were less likely to die within 30 days (adjusted OR: 0.51, 95%\u2009CI: 0.32 to 0.83), 60 days (OR: 0.56, 95%\u2009CI: 0.37 to 0.85) and 90 days (OR: 0.55, 95%\u2009CI: 0.37 to 0.82) after diagnosis of COVID-19. Those with low-intensity\/moderate-intensity statin use had significantly lower mortality risk in the 60-day and the 90-day follow-up period, while the high intensity of statin use was only found to be significantly associated with a lower odd of mortality within 30 days post index.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>After COVID infection, Medicaid beneficiaries who had taken statins antecedently could be at lower risk for death. For patients with chronic conditions, continuity of care is crucial when interruptions occur in their medical care. Further research is required to further investigate the potential mechanisms and optimal use of statins in COVID-19 treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-076195","type":"journal-article","created":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T02:16:26Z","timestamp":1700446586000},"page":"e076195","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Association of antecedent statin use on 30-day, 60-day and 90-day mortality among Mississippi Medicaid beneficiaries diagnosed with COVID-19"],"prefix":"10.1136","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8571-3872","authenticated-orcid":false,"given":"Yiran","family":"Rong","sequence":"first","affiliation":[{"name":"Department of Pharmacy Administration, University of Mississippi School of Pharmacy, University, Mississippi, USA"},{"name":"MedTech Epidemiology and Real-World Data Sciences, Johnson and Johnson, New Brunswick, New Jersey, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swarnali","family":"Goswami","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Administration, University of Mississippi School of Pharmacy, University, Mississippi, USA"},{"name":"Real-World Evidence, Complete Health Economics and Outcomes Solutions, LLC, Chalfont, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omokhodion","family":"Eriakha","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Administration, University of Mississippi School of Pharmacy, University, Mississippi, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8792-4307","authenticated-orcid":false,"given":"Sujith","family":"Ramachandran","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Administration, University of Mississippi School of Pharmacy, University, Mississippi, USA"},{"name":"Center for Pharmaceutical Marketing and Management, University of Mississippi School of Pharmacy, University, Mississippi, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Bentley","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Administration, University of Mississippi School of Pharmacy, University, Mississippi, USA"},{"name":"Center for Pharmaceutical Marketing and Management, University of Mississippi School of Pharmacy, University, Mississippi, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Benjamin F","family":"Banahan","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Administration, University of Mississippi School of Pharmacy, University, Mississippi, USA"},{"name":"Center for Pharmaceutical Marketing and Management, University of Mississippi School of Pharmacy, University, Mississippi, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terri","family":"Kirby","sequence":"additional","affiliation":[{"name":"Mississippi Division of Medicaid, Office of the Governor, Jackson, Mississippi, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Smith","sequence":"additional","affiliation":[{"name":"Mississippi Division of Medicaid, Office of the Governor, Jackson, Mississippi, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Pittman","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Administration, University of Mississippi School of Pharmacy, University, Mississippi, USA"},{"name":"Center for Pharmaceutical Marketing and Management, University of Mississippi School of Pharmacy, University, Mississippi, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaustuv","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Administration, University of Mississippi School of Pharmacy, University, Mississippi, USA"},{"name":"Center for Pharmaceutical Marketing and Management, University of Mississippi School of Pharmacy, University, Mississippi, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"239","published-online":{"date-parts":[[2023,11,19]]},"reference":[{"key":"2025121605222673000_13.11.e076195.1","unstructured":"CDC . 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