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The association of disease activity, social support and psychological distress with patients with CD was also evaluated based on the collected data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 162\u2009patients with CD were enrolled. Compared with patients with CD in remission (CD-R), the patients with CD in activity (CD-A) had higher C reactive protein (CRP) (p=0.001), anaemia (p&lt;0.001) and relapse rates in the last year (p&lt;0.001). Independent samples t-tests indicated that the CD-A group reported lower Social Support Rating Scale scores and higher Symptom Checklist-90 scores than the CD-R group. Moreover, men with CD had lower somatisation (p=0.030) and anxiety (p=0.050) scores than women. In binary logistic regression models, the subjective support (beta=0.903, p=0.013), the clinical factors of CRP (beta=1.038, p=0.001) and psychological distress factors of anxiety (beta=1.443, p=0.008) and other (beta=1.235, p=0.042) were disease activity predictors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The findings highlight the importance of the psychological distress and social support factors that may play a role in CD patients\u2019 health. Interventions to address these issues should be part of management in CD.<\/jats:p><\/jats:sec>","DOI":"10.1136\/bmjopen-2023-076219","type":"journal-article","created":{"date-parts":[[2023,10,25]],"date-time":"2023-10-25T03:21:46Z","timestamp":1698204106000},"page":"e076219","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":8,"title":["Is disease activity associated with social support and psychological distress in Crohn\u2019s disease patients? 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