{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:18:07Z","timestamp":1771467487396,"version":"3.50.1"},"reference-count":48,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T00:00:00Z","timestamp":1702512000000},"content-version":"unspecified","delay-in-days":13,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","award":["Protocol number 88887.687413\/2022-00"],"award-info":[{"award-number":["Protocol number 88887.687413\/2022-00"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,11,30]]},"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Molar incisor hypomineralisation (MIH) is a qualitative defect of enamel development that occurs in the mineralisation phase. MIH affects one or more permanent molars and, occasionally, permanent incisors. The aim of the proposed study is to evaluate the clinical effect of antimicrobial photodynamic therapy (aPDT) on permanent teeth with MIH through decontamination and sensitivity control.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>\n                      Patients from 8 to 12 years of age with permanent molars will be randomly allocated to three groups. Group 1: selective chemical\u2013mechanical removal of carious dentinal tissue around the walls of the cavity with Papac\u00e1rie Duo and a curette followed by the application of aPDT and deproteinisation with Papac\u00e1rie Duo; group 2: selective removal of carious dentinal tissue around the walls of the cavity with a curette, followed by the application of aPDT and deproteinisation with a 5% sodium hypochlorite solution; group 3: selective removal of carious dentinal tissue using a curette. The selected teeth must have a carious lesion in the dentin and posteruptive enamel breakdown on one or more surfaces with an indication for clinical restorative treatment. The teeth will subsequently be restored using a mixed technique with resin-modified glass ionomer cement and bulk-fill composite resin. The data will be submitted to descriptive statistical analysis. Associations with age and sex will be tested using either the \u03c7\n                      <jats:sup>2<\/jats:sup>\n                      test or Fisher\u2019s exact test. Pearson\u2019s correlation coefficients will be calculated to determine the strength of correlations between variables. Comparisons of the microbiological results (colony-forming units) will be performed using analysis of variance and the Kruskal-Wallis test. Kaplan-Meier survival analysis will be performed to assess the performance of the restorations.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>This protocol has been approved by the Human Research Ethics Committee of Nove de Julho University (certificate number: 61027522.0.0000.5511\/approval date: 23 August 2022). The findings will be published in a peer-reviewed journal.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT05443035\">NCT05443035<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-076226","type":"journal-article","created":{"date-parts":[[2023,12,15]],"date-time":"2023-12-15T02:09:02Z","timestamp":1702606142000},"page":"e076226","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":1,"title":["Evaluation of antimicrobial photodynamic therapy and minimal intervention associated with deproteinisation in permanent teeth with molar incisor hypomineralisation: study protocol for a clinical, controlled, blinded trial"],"prefix":"10.1136","volume":"13","clinical-trial-number":[{"clinical-trial-number":"nct05443035","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct05443035","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Amanda Rafaelly Hon\u00f3rio","family":"Mandetta","sequence":"first","affiliation":[{"name":"Postgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, Campus Vergueiro, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina Carvalho","family":"Bortoletto","sequence":"additional","affiliation":[{"name":"School of Dentistry, Universidade Nove de Julho, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6846-6574","authenticated-orcid":false,"given":"Ana Paula Taboada","family":"Sobral","sequence":"additional","affiliation":[{"name":"Postgraduation Program in Health and Environment, Universidade Metropolitana de Santos, Santos, SP, Brazil"},{"name":"School of Dentistry, Universidade Metropolitana de Santos, Santos, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela Let\u00edcia Leal","family":"Gon\u00e7alves","sequence":"additional","affiliation":[{"name":"Postgraduation Program in Health and Environment, Universidade Metropolitana de Santos, Santos, SP, Brazil"},{"name":"School of Dentistry, Universidade Metropolitana de Santos, Santos, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7774-4345","authenticated-orcid":false,"given":"Lara Jansiski","family":"Motta","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, Campus Vergueiro, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3476-9064","authenticated-orcid":false,"given":"Anna Carolina Ratto Tempestini","family":"Horliana","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, Campus Vergueiro, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel Agnelli Mesquita","family":"Ferrari","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, Campus Vergueiro, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renato Araujo","family":"Prates","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, Campus Vergueiro, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0014-6953","authenticated-orcid":false,"given":"Alessandro Melo","family":"Deana","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Biophotonics Applied to Health Sciences, Universidade Nove de Julho, Campus Vergueiro, S\u00e3o Paulo, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rita de C\u00e1ssia Loiola","family":"Cordeiro","sequence":"additional","affiliation":[{"name":"Research of Department of Pediatric Dentistry, Universidade Estadual Paulista J\u00falio de Mesquita Filho, Campus de Araraquara, Araraquara, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lourdes Aparecida Martins dos Santo","family":"Pinto","sequence":"additional","affiliation":[{"name":"Research of Department of Pediatric Dentistry, Universidade Estadual Paulista J\u00falio de Mesquita Filho, Campus de Araraquara, Araraquara, SP, 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