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The pretransplant treatment results in a general deterioration of the patient\u2019s health and quality of life. Furthermore, allo-HSCT can be responsible for significant toxicity with risks of graft-versus-host disease (GvHD). Developing strategies to prevent physical deconditioning, undernutrition and psychological distress could help maintain a satisfactory general state of health before transplantation and thus limit these deleterious effects. This protocol evaluates the feasibility and adherence to a personalised prehabilitation programme, which can be modulated and assisted by connected objects, provided from the diagnosis to the allo-HSCT.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods and analysis<\/jats:title>\n                    <jats:p>This multicentre interventional study will include 50 patients treated for AML or high-risk MDS with intensive chemotherapy and eligible for allo-HSCT. The intervention consists of a coached, supervised or self-directed physical activity programme, organised during the hospitalisation phases and periods at home. At the same time, patients will receive a weekly dietary follow-up. The whole intervention is controlled and modulated through the use of a dedicated application and connected objects allowing adaptation and individualisation. The rate of participation in the prescribed physical activity sessions will assess the feasibility of this study. In addition, the evolution of physical capacities (Short Physical Performance Battery, grip and quadriceps strengths), psychosocial parameters (Functional Assessment of Cancer Therapy - Leukaemia, Functional Assessment of Cancer Therapy - Fatigue, subjective well-being, Hospital Anxiety and Depression Scale, self-efficacy, Coach-Athlete Relationship Questionnaire, interviews) and clinical status (weight, lean body mass, survival rate, number of infections, days of hospitalisation, GvHD) will be evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Ethics and dissemination<\/jats:title>\n                    <jats:p>The study procedures have been approved by the National Ethics Committee (21.00223.000003). Consent is given in person by each participant. The information collected on the participants contains only a non-identifiable study identifier. The results of this protocol will be published in a scientific paper and communicated to the medical staff of the medical centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial registration number<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT03595787\">NCT03595787<\/jats:ext-link>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-076321","type":"journal-article","created":{"date-parts":[[2024,3,29]],"date-time":"2024-03-29T22:11:16Z","timestamp":1711750276000},"page":"e076321","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":0,"title":["Tripartite prehabilitation of patients with acute myeloid leukaemia and high-risk myelodysplastic syndromes during intensive chemotherapy before allogeneic haematopoietic stem cell transplantation (COHABILIT): protocol for an innovating prospective multicentre study"],"prefix":"10.1136","volume":"14","clinical-trial-number":[{"clinical-trial-number":"nct03595787","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Colombe","family":"Saillard","sequence":"first","affiliation":[{"name":"Department of Haematology, Paoli-Calmettes Institute, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8762-8738","authenticated-orcid":false,"given":"Sarah","family":"Cuvelier","sequence":"additional","affiliation":[{"name":"Management Sport Cancer Laboratory, Aix-Marseille University, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2589-3661","authenticated-orcid":false,"given":"Charl\u00e8ne","family":"Villaron-Goetgheluck","sequence":"additional","affiliation":[{"name":"Management Sport Cancer Laboratory, Aix-Marseille University, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Marie","family":"Boher","sequence":"additional","affiliation":[{"name":"Department of Clinical Research and Innovations, Paoli-Calmettes Institute, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonor","family":"Almeida-Lopez","sequence":"additional","affiliation":[{"name":"Department of Clinical Research and Innovations, Paoli-Calmettes Institute, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Gaelle","family":"Le Corroller","sequence":"additional","affiliation":[{"name":"Economic and Social Sciences of Health and Medical Information Processing Laboratory (SESSTIM CANBIOS), National Institute of Health and Medical Research, Paris, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pauline","family":"Denis","sequence":"additional","affiliation":[{"name":"Department of Sport, Paoli-Calmettes Institute, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9line","family":"Rivieccio","sequence":"additional","affiliation":[{"name":"Department of Sport, Paoli-Calmettes Institute, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"Calvin","sequence":"additional","affiliation":[{"name":"Management Sport Cancer Laboratory, Aix-Marseille University, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7027-040X","authenticated-orcid":false,"given":"Norbert","family":"Vey","sequence":"additional","affiliation":[{"name":"Department of Haematology, Paoli-Calmettes Institute, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9cile","family":"Bannier-Braticevic","sequence":"additional","affiliation":[{"name":"Department of Oncology, Paoli-Calmettes Institute, Marseille, France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2024,3,29]]},"reference":[{"key":"2025121601143683000_14.3.e076321.1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.blre.2017.08.001","article-title":"Treatment of acute myeloid leukemia in the next decade - 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