{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T05:36:40Z","timestamp":1771565800133,"version":"3.50.1"},"reference-count":17,"publisher":"BMJ","issue":"11","license":[{"start":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T00:00:00Z","timestamp":1699574400000},"content-version":"unspecified","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"name":"National Key Clinical Specialty Construction Project","award":["2020-QTL-009"],"award-info":[{"award-number":["2020-QTL-009"]}]},{"name":"Beijing Research Ward Construction Clinical Research Project","award":["2022-YJXBF-04-03"],"award-info":[{"award-number":["2022-YJXBF-04-03"]}]},{"name":"Capital\u2019s Funds for Health Improvement and Research","award":["2022-1-4062"],"award-info":[{"award-number":["2022-1-4062"]}]},{"name":"Chinese Society of Cardiology Foundation","award":["CSCF2021B02"],"award-info":[{"award-number":["CSCF2021B02"]}]},{"name":"National High Level Hospital Clinical Research Funding","award":["2022-NHLHCRF-YSPY-01"],"award-info":[{"award-number":["2022-NHLHCRF-YSPY-01"]}]},{"name":"Elite Medical Professionals Project of China-Japan Friendship Hospital","award":["ZRJY2021-QM22"],"award-info":[{"award-number":["ZRJY2021-QM22"]}]}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,10,16]]},"published-print":{"date-parts":[[2023,11]]},"abstract":"<jats:sec>\n                  <jats:title>Introduction<\/jats:title>\n                  <jats:p>ST-segment elevation myocardial infarction (STEMI) with high thrombus burden is associated with a poor prognosis. Manual aspiration thrombectomy reduces coronary vessel distal embolisation, improves microvascular perfusion and reduces cardiovascular deaths, but it promotes more strokes and transient ischaemic attacks in the subgroup with high thrombus burden. Intrathrombus thrombolysis (ie, the local delivery of thrombolytics into the coronary thrombus) is a recently proposed treatment approach that theoretically reduces thrombus volume and the risk of microvascular dysfunction. However, the safety and efficacy of intrathrombus thrombolysis lack sufficient clinical evidence.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods and analysis<\/jats:title>\n                  <jats:p>The intrAThrombus Thrombolysis versus aspiRAtion thrombeCTomy during prImary percutaneous coronary interVEntion trial is a multicentre, prospective, open-label, randomised controlled trial with the blinded assessment of outcomes. A total of 2500 STEMI patients with high thrombus burden who undergo primary percutaneous coronary intervention will be randomised 1:1 to intrathrombus thrombolysis with a pierced balloon or upfront routine manual aspiration thrombectomy. The primary outcome will be the composite of cardiovascular death, recurrent myocardial infarction, cardiogenic shock, heart failure readmission, stent thrombosis and target-vessel revascularisation up to 180 days.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Ethics and dissemination<\/jats:title>\n                  <jats:p>The trial was approved by Ethics Committees of China-Japan Friendship Hospital (2022-KY-013) and all other participating study centres. The results of this trial will be published in peer-reviewed journals.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Trial registration number<\/jats:title>\n                  <jats:p>\n                     <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"clintrialgov\" xlink:href=\"NCT05554588\">NCT05554588<\/jats:ext-link>.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-076476","type":"journal-article","created":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T12:08:16Z","timestamp":1699618096000},"page":"e076476","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":5,"title":["Design and rationale of the ATTRACTIVE trial: a randomised trial of intrAThrombus Thrombolysis versus aspiRAtion thrombeCTomy during prImary percutaneous coronary interVEntion in ST-segment elevation myocardial infarction patients with high thrombus burden"],"prefix":"10.1136","volume":"13","clinical-trial-number":[{"clinical-trial-number":"nct05554588","registry":"10.18810\/clinical-trials-gov"},{"clinical-trial-number":"nct05554588","registry":"10.18810\/clinical-trials-gov"}],"author":[{"given":"Zhen","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Cardiology, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoxue","family":"Sheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wuqiang","family":"Che","sequence":"additional","affiliation":[{"name":"Department of Cardiology, China-Japan Friendship Hospital, Beijing, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuoyan","family":"An","sequence":"additional","affiliation":[{"name":"Department of Cardiology, China-Japan 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