{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T03:49:22Z","timestamp":1768535362143,"version":"3.49.0"},"reference-count":26,"publisher":"BMJ","issue":"12","license":[{"start":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T00:00:00Z","timestamp":1703721600000},"content-version":"unspecified","delay-in-days":27,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["bmj.com"],"crossmark-restriction":true},"short-container-title":["BMJ Open"],"accepted":{"date-parts":[[2023,12,7]]},"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>The main objective of the study was to evaluate the influence of arterial hypertension, diabetes, dyslipidaemia, smoking, alcoholism and COPD (chronic obstructive pulmonary disease) on the viability of the extracted tissue as well as the donor.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Design<\/jats:title>\n                    <jats:p>Observational case\u2013control study.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Setting<\/jats:title>\n                    <jats:p>Regional hospital in Northern Spain.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Participants<\/jats:title>\n                    <jats:p>1517 corneas were registered.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Interventions<\/jats:title>\n                    <jats:p>Patients\u2019 medical history was reviewed after corneal donation and evaluation. Previous medical information (age, sex and cardiovascular risk factors (CVRFs)) and data related to the donor (type of donor), the corneal tissue and its evaluation, and the viability of the implant were collected.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 1517 corneas were registered and 81.5% of the donors presented at least one CVRF. In relation to the viability of the donor, it was observed that having suffered from COPD reduced the viability of the donor (no COPD: 93.8% vs COPD: 88%; OR=0.49; 95% CI: 0.28 to 0.84) while alcohol consumption increased it (drinker or ex-drinker: 95.8% vs non-drinker: 92.5%; OR=1.84; 95% CI: 1.01 to 3.33). Regarding tissue viability, decreased viability was observed in the presence of COPD (no COPD: 72.5% vs COPD: 64; OR=0.67; 95% CI: 0.47 to 0.96) and diabetes mellitus (no diabetes: 72.9% vs diabetes: 67.2%; OR=0.76; 95% CI: 0.58 to 0.99). As regards the viability of the implant, a total of 1039 corneas (68.9%) were suitable, observing decreased viability when suffering from COPD (no COPD: 69.8% vs COPD: 60.7%; OR=0.67; 95% CI: 0.47 to 0.94) and increased when having an active smoking habit (no habit: 65.3% vs habit: 74.1%; OR=1.52; 95% CI: 1.21 to 1.91).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Through this study, it can be concluded that in the absence of absolute exclusion criteria for donors, the assessment of how CVRF, alcoholism and COPD may affect the donor provides details about the quality of the tissue to be obtained.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1136\/bmjopen-2023-077122","type":"journal-article","created":{"date-parts":[[2023,12,28]],"date-time":"2023-12-28T12:16:23Z","timestamp":1703765783000},"page":"e077122","update-policy":"https:\/\/doi.org\/10.1136\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":2,"title":["Analysis of cardiovascular risk factors for the viability of cornea donors: a case\u2013control study"],"prefix":"10.1136","volume":"13","author":[{"given":"Alejandro","family":"Montero-Salinas","sequence":"first","affiliation":[{"name":"Biomedical Research Institute of A Coru\u00f1a (INIBIC), Universidade da Coru\u00f1a, A Coruna, Spain"},{"name":"Universidade da Coru\u00f1a (UDC), A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Mart\u00ednez-Isasi","sequence":"additional","affiliation":[{"name":"Simulation and Intensive Care Unit of Santiago (SICRUS), Health Research Institute of Santiago, University Hospital of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"CLINURSID Research Group, University of Santiago de Compostela, Santiago de Compostela, Spain"},{"name":"Primary Care Interventions to Prevent Maternal and Child Chronic Diseases of Perinatal and Developmental Origin (RICORS), Instituto de Salud Carlos III, RD21\/0012\/0025, Madrid, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva","family":"Fieira-Costa","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute of A Coru\u00f1a (INIBIC), Universidade da Coru\u00f1a, A Coruna, Spain"},{"name":"Department of Thoracic Surgery and Lung Transplant, Coru\u00f1a University Hospital, Servizo Galego de Sa\u00fade (SERGAS), Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorge","family":"Suanzes-Hern\u00e1ndez","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute of A Coru\u00f1a (INIBIC), Universidade da Coru\u00f1a, A Coruna, Spain"},{"name":"Research Group in Nursing and Health Care, Instituto de Investigaci\u00f3n Biom\u00e9dica de A Coru\u00f1a (INIBIC), Complexo Hospitalario Universitario de A Coru\u00f1a (CHUAC), Sergas, Universidade da Coru\u00f1a (UDC), A Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Fern\u00e1ndez-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Nursing Health Research Group - GREIS, Department of Nursing and Physiotherapy, University of Le\u00f3n, Leon, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9053-7730","authenticated-orcid":false,"given":"Juan","family":"G\u00f3mez-Salgado","sequence":"additional","affiliation":[{"name":"Department of Sociology, Social Work and Public Health, University of Huelva, Huelva, Spain"},{"name":"Health and Safety Postgraduate Programme, Universidad de Especialidades Espiritu Santo, Samborondon, Ecuador"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esther","family":"Rendal-Vazquez","sequence":"additional","affiliation":[{"name":"Biomedical Research Institute of A Coru\u00f1a (INIBIC), Universidade da Coru\u00f1a, A Coruna, Spain"},{"name":"Unidade de Criobiolox\u00eda-Banco de Tecidos, Complexo Hospitalario Universitario A Coru\u00f1a (CHUAC), Servizo Galego de Sa\u00fade (SERGAS), Coru\u00f1a, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"239","published-online":{"date-parts":[[2023,12,28]]},"reference":[{"key":"2025121300111703000_13.12.e077122.1","unstructured":"Organizaci\u00f3n Nacional de Trasplantes . 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